Senior Scientist, Cell Biology

Senior Scientist, Cell Biology Location: Palo Alto, CA About GondolaBio GondolaBio is a clinical‑stage biopharmaceutical company focused on developing next‑generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting‑edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation. Who You Are A cell biologist who focuses on building cellular models for genetic disorders with a significant unmet medical need, where your work will directly translate from the bench to potentially life‑altering therapies. Scientifically rigorous, detail‑oriented and execution‑focused, with a strong foundation in cell biology techniques to deliver high‑quality, decision‑ready data to bridge the gap between initial molecular design and translational reality. Thrives in a fast‑paced, biotech environment with a lean organization. A pragmatic communicator who can synthesize complex data into actionable insights, clearly articulate experimental rationale, assay performance, and translational relevance to cross‑functional and leadership members. Key Responsibilities Cell Model Development & Functional Biology Develop and optimize disease‑relevant cellular models to enable preclinical drug screening. Perform genetic manipulation and engineering of primary cell systems to interrogate target biology. Trans‑differentiate primary cells into specialized lineages to enable disease‑relevant functional assays. Design and execute experiments to investigate RNA processing, gene expression regulation, and downstream cellular phenotypes. Mechanistic Biology & Data Interpretation Analyze complex cellular datasets to uncover mechanisms of action and inform program strategy. Identify and characterize molecular phenotypes related to RNA splicing and cellular dysfunction using biochemical and imaging techniques. Perform drug screening using cellular models to guide lead optimization. Perform RNA‑seq, proteomics, and relevant assays to assess potential off‑target risks. Translate experimental findings into clear biological hypotheses and next‑step recommendations. CRO & External Collaboration Lead scientific oversight of external partners and CROs conducting cell‑based and molecular studies. Design studies, review protocols, and ensure high‑quality data generation aligned with program goals. Serve as a key point of contact to drive efficient execution and clear communication. Cross‑Functional Collaboration Partner with chemistry, translational, and computational teams to integrate data and guide decision‑making. Present findings to internal stakeholders and contribute to program strategy discussions. Preferred Education & Experience Ph.D. in cell biology, molecular biology, or a related field. 3+ years of post‑doctoral research or industry experience in drug discovery or early development. Strong experience with primary human cell culture and engineering. Strong expertise in RNA‑seq, RT‑PCR, RT‑qPCR for gene splicing analysis. Proven track record of working with complex cellular models and functional assays. Excellent data analysis, visualization, and scientific communication skills. Nice‑to‑Haves Experience with cell differentiation into specialized lineages (e.g., muscle or other relevant cell types). Familiarity with RNA biology, including splicing or transcript processing assays. First‑author publications in muscle cell biology/pathology. Experience supporting or contributing to IND‑enabling studies. Background in translating patient‑derived cell phenotypes into drug discovery insights. Values & Culture Patient Champions, who put patients first and uphold strict ethical standards. Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset. Truth Seekers, who are detailed, rational, and humble problem solvers. Individuals who inspire excellence in themselves and those around them. High‑quality executors, who execute against goals and milestones with quality, precision, and speed. What We Offer Patient Days and a culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let science speak. An uncompromising commitment to always putting patients first. A de‑centralized model that enables program teams to focus on advancing science and helping patients. A place where you own the vision – both for your program and your own career path. A collaborative, fast‑paced, data‑driven environment that inspires all members to perform at the top of their game. Access to learning and development resources to help you reach the best professional shape. Robust, market‑competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs). Flexible PTO. Rapid career advancement for strong performers. Potential ability to work on multiple GondolaBio Pharma programs across therapeutic areas over time. Partnerships with leading institutions. Commitment to Diversity, Equity & Inclusion. The base pay range for this position is $155,000 to $175,000 per year. The actual compensation offered will be determined based on a number of job‑related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered. #J-18808-Ljbffr GondolaBio