Executive Medical Director- Nephrology

Job Description General Summary The Executive Medical Director, Clinical Development will provide high-level input on clinical development strategies to povetacicept renal programs, in conjunction with other relevant functional area leaders in Medical Affairs, Regulatory, Global Patient Safety, Clinical Operations, Exploratory Development, Commercial, Pharmaceutical Development, Research, Business Development, and Marketing. Initiate and lead innovative approaches to clinical development. Key Duties and Responsibilities Broad and comprehensive understanding of the drug development process Well-respected authority in the external clinical development community Provide clinical development recommendations to project teams, including optimizing study design and conduct for efficiency and effectiveness. Participate in planning for worldwide clinical development activities Provide guidance to multi-disciplinary development teams Review study protocols Review Investigator Brochures Review and evaluate study subject exemptions Oversee medical monitoring of clinical studies Evaluate adverse events and overall safety profile Participate in data reviews Interface with international regulatory authorities, as appropriate, in support of the development objectives for the compound or program Ensure compliance with Vertex Standard Operating Procedures, International Conference on Harmonization, Good Clinical Practice, and other national and international regulatory requirements As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned staff. Knowledge and Skills Global clinical research experience and experience interacting with regulatory authorities is highly desired Possesses a comprehensive understanding of applicable US and EU regulatory requirements and of the drug development process Possesses a working knowledge of biostatistics, data management, clinical operations and clinical pharmacokinetic scientific and technical processes Experience in filing and defending US INDs and/or NDAs and/or their international equivalents Enterprise-wide thinking and ability to work in ambiguity, including being hands on in order to ensure the work that needs to be done by the team gets done; other duties as required or assigned Ability to work and lead collaboratively in a challenging fast-paced, team-based matrix environment Ability to work independently to resolve challenges and conflicts Excellent oral and written communication Excellent leadership skills Board certification/eligibility in a medical specialty desired. Education and Experience MD, DO or equivalent ex-US medical degree 15 years pharmaceutical industry experience, including time managing clinical trials and/or clinical development program(s), or the equivalent combination of education and experience 7 years of management experience #LI-JM1 Pay Range and Disclosure Statement Pay Range: $320,000 - $480,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as:

1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io. Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha‑1 antitrypsin deficiency. Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work. #J-18808-Ljbffr Vertex Pharmaceuticals LLC