Principal Scientist, Translational Clinical Biomarkers - Hematology/Oncology
$190.8k - $300.3kMSD Malaysia
- # Principal Scientist, Translational Clinical Biomarkers - Hematology/OncologyApply: Hybrid: USA - Pennsylvania - North Wales (Upper Gwynedd): USA - Massachusetts - Boston (MA Parcel B Laboratory): USA - New Jersey - Rahway: USA - California - South San Francisco (Grand Ave): Full time: Posted Today: End Date: October 9, 2026 (22 days left to apply): R417644**Job Description**We are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership across programs within the Oncology and Hematology portfolios.This role will lead the design, execution, analysis, and communication of translational and clinical biomarker strategies across programs spanning early through late clinical development.The successful candidate will develop decision-centric biomarker strategies that integrate therapeutic mechanism, tumor or disease biology, pharmacodynamics, molecular heterogeneity, patient selection, response and resistance, dose and regimen selection, and clinical endpoints. Biomarker plans should focus on generating high-value, interpretable evidence that informs program decisions rather than data generation alone.Key Responsibilities\\* Develop and lead integrated biomarker strategies across oncology and hematology programs, in partnership with cross-functional development teams.\\* Translate disease biology and therapeutic mechanism into clear translational hypotheses and fit-for-purpose biomarker approaches.\\* Define how biomarkers can inform key development questions including proof of biology, target engagement, dose and regimen selection, patient selection, response assessment, resistance mechanisms, and go/no-go decisions.\\* Ensure biomarker strategies are focused and scalable, with clear linkage between the development question, proposed measurement, expected result, and potential action.\\* Serve as the biomarker representative on cross-functional program teams and provide strategic biomarker input to program-level decision making.\\* Partner closely with Discovery, Clinical Development, Quantitative Sciences, Regulatory, Data Science, Clinical Operations, Pathology, Diagnostics, and other functions to develop integrated translational strategies.\\* Lead interpretation of biomarker and clinical datasets and translate complex findings into clear, actionable recommendations.\\* Develop approaches to characterize disease heterogeneity, molecular drivers, treatment response, mechanisms of resistance, and biological determinants of clinical outcome.\\* Develop and evaluate patient-selection and precision-medicine strategies, including approaches based on genomic, transcriptomic, protein-expression, cellular, or other disease-specific biomarkers.\\* Apply circulating and tissue-based biomarker approaches, as appropriate, including ctDNA, minimal residual disease, molecular profiling, immunophenotyping, and pharmacodynamic biomarkers.\\* For hematologic malignancies, develop strategies incorporating disease-relevant measures such as molecular response, measurable residual disease, clonal evolution, mutational burden, lineage or cellular phenotype, and resistance-associated alterations, as appropriate to the program.\\* For solid tumors, develop strategies addressing target expression, tumor biology, molecular subtype, immune contexture, circulating biomarkers, mechanisms of response and resistance, and potential predictive biomarkers.\\* Evaluate emerging biomarker technologies and analytical approaches based on their ability to address meaningful development questions and influence program decisions.\\* Contribute to biomarker strategies supporting potential companion diagnostic or regulatory biomarker development, where appropriate.\\* Communicate biomarker strategies, results, risks, and recommendations clearly to cross-functional teams, governance groups, and key stakeholders.\\* Provide scientific guidance and mentorship to biomarker scientists and contribute to a collaborative, strategically focused biomarker organization.\\* Support publications, scientific presentations, external collaborations, and interactions with key external experts as appropriate.QualificationsEducationPh.D., M.D., or equivalent advanced scientific degree with relevant experience in oncology, hematology, translational medicine, biomarker science, drug development, or a related discipline.Required Experience and Skills\\* Significant experience developing and executing translational or clinical biomarker strategies in oncology or hematology drug development.### ### \\* Strong scientific expertise in cancer biology, hematologic malignancies, translational oncology, or a related discipline.\\* Demonstrated ability to translate scientific hypotheses into biomarker strategies that inform clinical development decisions.\\* Strong understanding of the relationship between mechanism of action, disease biology, molecular heterogeneity, pharmacology, biomarkers, clinical endpoints, and development strategy.\\* Experience with one or more relevant biomarker modalities, such as NGS, ctDNA, MRD, immunohistochemistry, flow cytometry, gene-expression profiling, proteomics, or other molecular and cellular approaches.\\* Ability to lead cross-functional scientific work in a matrixed environment and influence without direct authority.\\* Strong analytical and problem-solving skills, including the ability to synthesize complex and multidimensional datasets into clear, decision-oriented conclusions.\\* Ability to prioritize high-value, decision-enabling biomarker work and distinguish it from lower-priority exploratory activities.\\* Excellent written and verbal communication skills and the ability to communicate scientific strategy to stakeholders.\\* Working knowledge of biostatistics, bioinformatics, quantitative sciences, and multidimensional biomarker data analysis.\\* Strategic mindset with a focus on scientific rigor, prioritization, scalability, and generation of actionable evidence.Preferred Experience and Skills### \\* Experience supporting oncology or hematology programs across multiple stages of clinical development.\\* Experience with predictive, pharmacodynamic, prognostic, resistance, MRD, or precision-medicine biomarker strategies.\\* Experience integrating tissue, blood, molecular, and cellular biomarker data with clinical outcomes.\\* Experience supporting biomarker strategies for targeted therapies, immune-based therapies, antibody-drug conjugates, cell therapies, bispecifics, or other novel therapeutic modalities.\\* Familiarity with companion diagnostic development and associated regulatory considerations.\\* Experience working across multiple programs or disease areas.\\* Experience mentoring or providing scientific direction to other scientists.**Required Skills:**Biomarkers, Clinical Development, Clinical Research, Ethical Compliance, Immuno-Oncology, Mechanism of Action, Oncology, Patient Care, Pharmacodynamics, Protocol Development, Research Designs, Scientific Presentations, Scientific Writing, Strategic Thinking, Translational Medicine**Preferred Skills:**Current Employees apply HERECurrent Contingent Workers apply HERE**US and Puerto Rico Residents Only:**Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your RightsEEOC GINA SupplementWe are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State ActsThe salary range for this role is$190,800.00 - $300,300.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.**San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance**Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance**Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.**Employee Status:**Regular**Relocation:**Domestic**VISA Sponsorship:**No**Travel Requirements:**10%**Flexible Work Arrangements:**Hybrid**Shift:**1st - Day**Valid Driving License:**No**Hazardous Material(s):**N/A**Job Posting End Date:**10/9/2026**\\*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.**Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
- J-18808-Ljbffr MSD Malaysia
Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Principal Scientist, Translational Clinical Biomarkers - Hematology/Oncology in Eastern, KY vacancy
$255.8k - $402.7k
## Principal Scientist, Translational Medicine, NeuroscienceApply: Hybrid: USA - Pennsylvania - West Point... ...group as a **Principal Scientist (Clinical Director) in Translational Medicine... ...validate established and novel clinical biomarkers, including blood/tissue sampling,...PrincipalFull timeFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hours- ...creative, and highly collaborative scientist to lead the Cellular Biology... ...in bone marrow biology and hematology, coupled with extensive... ...developing cell-based translational models of human hematologic... ...programs into and through the clinic. RESPONSIBILITIES Lead and...Principal
$157.02k - $235.52k
...Personnel & Faculty: School of Medicine: Pediatrics: Pediatrics, Hematology/Oncology Location Seattle, WA Open Date Jul 24, 2025 Description... ...Assistant Professor, Associate Professor or Professor of Clinical Practice level. Salary and academic appointment at University...SuggestedFull timeH1bWork at officeNight shift- NeoGenomics is seeking a Principal Scientist Algorithm Lead - Clinical NGS Diagnostics to provide end-to-end scientific leadership for clinical-grade algorithms with a focus on oncology and liquid biopsy. This is a remote position. You will own algorithm design, analytical...PrincipalRemote job
$173.1k - $321.5k
...with the people we love. The Senior Principal Scientist serves as the scientific leader... ...Bioanalytical Sciences, Research, Translational Medicine, Clinical Development, CMC, Regulatory, and... ...binding assays, functional bioassays, biomarker assays, and emerging multiomic...PrincipalLocal areaRelocation package$200k - $275k
...external candidates Explore opportunities with Kelsey-Seybold Clinic, part of the Optum family of businesses. Work with one of the nation... .... In collaboration with physicians and other Radiation Oncology professionals, this position helps ensure the delivery of safe,...Minimum wageFull timeWork experience placementLocal areaRelocation packageTexas Health Institute
Eastern, KY4 days ago- ...is looking for a Principal Scientist Algorithm Lead - Clinical NGS Diagnostics who... ...primary focus on oncology and liquid biopsy... ...for solid tumor and hematologic malignancy profiling... ...variants. Translate algorithm behavior... ...methods to NGS data or biomarker development. Expert...PrincipalRemote work
$170.6k - $255.8k
...content#Senior Staff Bioinformatics Scientist page is loaded## Senior... ...for transcriptomics, oncology, population genomics,... ...detection, and RNA biomarker development.*... ...Knowledge of oncology, clinical genomics, population genomics, translational research, or biotechnology...Local areaRemote workWorldwide$176.2k - $277.3k
...meetings focused primarily on immunology and oncology. This position requires exceptional... ...strategy and execution, and for the non-clinical safety sections of regulatory documents... ...industry experience as a non-clinical safety scientist (e.g. Toxicology, Pathology etc.) and/or...PrincipalFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$25.19 - $39.09 per hour
...Qualifications ~ Bachelor’s degree in a Chemical or Biological science, Clinical Laboratory Science or Medical Technology ~1 year or more of... ...~1 year or more of clinical laboratory testing experience in Hematology or Morphology ~ ASCP or AMT certification Additional...Hourly payTemporary workCasual workInternshipFlexible hoursShift workInternational Society on Thrombosis and Hemostasis
Eastern, KY4 days ago- ...Clinical Geneticist Northern Light Eastern Maine Medical Center , located in Bangor, Maine , seeks a BC/BE Clinical Geneticist... ..., neurology, cardiology, infectious disease, endocrinology, hematology-oncology, developmental pediatrics, genetics, surgery, orthopedics,...Relocation packageFlexible hours
ISONG
Eastern, KY16 hours ago - Principal Pharmacokinetics Scientist -(Permanent Remote role) United States ClinChoice is a global full-service... ...design, execution, and analysis of clinical pharmacology studies and other... ...pharmacokinetics, pharmacodynamics, translational sciences, and PK/PD data analysis....PrincipalRemote jobPermanent employment
- Encino Hospital Medical Center is seeking a qualified clinical laboratory professional to perform a broad array of tests across Hematology, Chemistry, Microbiology and related disciplines. You will adhere to strict lab procedures and participate in quality control to ensure...
$173.6k - $237k
## Senior Principal Scientist, Peptide Chemistry / API DevelopmentApply: On-Site: US CA San Diego... ...compounds in mid- to late-phase clinical development across our core therapeutic... ...resolve complex technical challenges, and translate evolving scientific and regulatory expectations...PrincipalFull timeFor contractors$92.6k - $172k
...bringing game-changing therapies from clinical phase I into the market to serve... ...Delivery Systems. The Opportunity The Principal Associate Scientist ensures robust clinical and... ...relevant industry experience Ability to translate expertise in chemical engineering, chemistry...PrincipalLocal areaRelocation package- ...Biosciences, Inc. in South San Francisco, CA, seeks a Senior Principal Research Scientist to lead the Protein Sciences team and hands-on protein... ..., Biophysics, Structural Biology, and Data Science to translate results into program decisions. Onsite four days per week...Principal
- ...intelligence platform for biotech/pharma R&D scientists that empowers them to discover the... ...organizations. We are looking for a Principal Scientists to join the Drug Hunter team... ...addition to responding to requests Translates scientific judgment and insight into business...PrincipalTemporary workRemote workHome officeFlexible hoursShift work
Drug Hunter Inc.
Eastern, KY1 day ago $128.6k - $210k
...medicines for people with serious diseases. We are seeking a Principal Scientist to join our Genetic Medicines team, helping advance the... ...team spanning platform technology, disease biology, and early clinical development. This position offers the opportunity to contribute...PrincipalWorldwide- ...member at the Assistant Professor or Associate Professor level (Clinical Scholar track) with a joint appointment. The successful... ...teaching, and mentorship, and contribute to outstanding clinical care and translational research initiatives. #J-18808-Ljbffr Go HuskiesFull time
$159.36k
...Job Description: Medical Physicist - Oncology Time Type: Full time Time Type: Full time Hours per Pay Period: 80... ...routine maintenance and quality assurance activities Demonstrated clinical Radiation Oncology knowledge of daily linear accelerator...Full timeWork at officeFlexible hoursShift workDay shiftBay Area Hospital
Eastern, KY16 hours ago- Boehringer Ingelheim is seeking a Senior Principal/ Principal Scientist, Computational Safety, to provide scientific leadership in in silico safety assessment across drug discovery and development. This role will leverage advanced multi omics data, systems toxicology and...Principal
- Prellis Biologics, a Berkeley-based biotech, seeks a Principal Scientist for Therapeutic Antibody Characterization to lead analytical characterization of mAbs, bispecifics, and Fc-fusion proteins, guiding candidate selection and preclinical development. You will apply biophysical...Principal
$184.55k - $204.55k
...CLINICAL GENETICIST JOB OPPORTUNITY The Division of Medical Genetics and Genomics at Albany Medical College is searching for a Clinical Geneticist. This position is an excellent opportunity for professional career growth and advancement in a reputable medical genetics...Relocation packageIsong
Eastern, KY4 days ago- ...base while manufacturing exclusively in the USA. This role will be located at our Cincinnati, Ohio facility. Role Overview The Principal Chemist leads the technical strategy for developing high-solids, UV-curable ceramic suspensions. This senior leader bridges the...PrincipalTemporary work
Beehive Industries
Eastern, KY4 days ago $200k - $225.12k
...Tufts Medical Center is accepting applications for a full-time Clinical Geneticist in the Division of Genetics. We are seeking an MD/... ...communities from Cape Cod to the New Hampshire border. As the principal teaching hospital for Tufts University School of Medicine,...Full timeAOIA
Eastern, KY4 days ago- Drug Hunter is seeking a Principal Scientist to lead scientific projects from end to end, defining scope and requirements with minimal direction. This role represents the company’s scientific strengths to external audiences and guides the team’s technical direction. The...Principal
- Drug Hunter Inc. is seeking a Principal Scientist to lead scientific programs end-to-end, define scope, and deliver high-quality results with minimal direction. The role includes mentoring early-career scientists and shaping plans with product development, engineering,...Principal
- Maimonides Medical Center is seeking a Radiation Oncology Physicist to ensure precise delivery of treatment plans and comprehensive QC... ...degree in Radiation Physics, with demonstrated experience in treatment planning and clinical QA. #J-18808-Ljbffr Maimonides Medical Center
$42.24 - $69.33 per hour
...POSITION SUMMARY: The Lead Clinical Lab Scientist is responsible for the operation of at least one specialty area of the laboratory, while on shift. Maintains instruments, quality control, procedures and inventory in order to supply accurate and timely laboratory results...Remote workShift workEl Centro Regional Medical Center
Eastern, KY16 hours ago$138.12k - $173.9k
...training in equitable management practices and tools to promote engaged, collaborative, and results-driven work environments. The Principal Scientist, Microbiology Has The Following Responsibilities Provides scientific leadership for USP’s microbiology reference material...PrincipalFull timeWork at officeWorldwide
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Scientist, Translational Clinical Biomarkers - Hematology/Oncology. Be the first to apply!
Related searches
- regulatory scientist Eastern, KY
- principal scientist Eastern, KY
- graduate scientist Eastern, KY
- manufacturing scientist Eastern, KY
- analytical scientist Eastern, KY
- senior research scientist Eastern, KY
- support scientist Eastern, KY
- application scientist Eastern, KY
- drug safety scientist Eastern, KY
- machine learning scientist Eastern, KY