Postdoctoral Scientist - Fibrosis, Liver Disease

Job Description

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

The Inflammation Biology group is seeking a passionate and driven postdoctoral scientist to pursue innovative research at the forefront of chronic fibrotic liver disease. This role offers a unique opportunity to explore the complex biology of conditions such as metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC).

The successful candidate will spearhead an independent research project focused on uncovering novel pathogenic mechanisms and identifying therapeutic targets in chronic fibrotic diseases. This work is expected to yield impactful insights into the pathogenesis of human disease and high-impact publications in leading scientific journals.

This is a three-year postdoctoral training position at Gilead. The role is embedded in a highly collaborative and resource-rich environment, offering access to world-class facilities and cross-functional expertise across Gilead’s research ecosystem.

Responsibilities:

• The successful candidate will lead independent research projects to investigate pathogenic mechanisms in chronic fibrotic liver disease
• They will utilize Gilead’s expensive single cell and spatial transcriptomic datasets as well as clinical datasets to uncover novel mechanisms driving fibrotic niche expansion
• The candidate will use a combination of mouse genetic and pharmacology approaches to investigate key disease drivers and establish novel ex vivo models allowing for target identification and screening
• With the support of a mentor, the postdoctoral scientist will design, conduct, and analyze in vitro and in vivo experiments to drive research towards publication in a top-tier journal.

The postdoctoral scientist will be expected to publish their work in top-tier journals and present at scientific conferences. The selected candidate will work in a highly collaborative environment at Gilead through a three-year fixed term, with access to world-class research facilities and the opportunity to leverage expertise and resources across multiple functional areas.

Basic Qualifications:

• Ph.D. in biochemistry, molecular biology, immunology or related discipline.
• At least one first author paper published or accepted in a peer-reviewed journal.
• Proficiency in mammalian cell biology and biochemistry techniques.
• Excellent written, verbal, and interpersonal communication skills and strong organizational skills are required.

Preferred Qualifications:

• Preference will be given to candidates with broad hands-on expertise in cell biology, molecular biology, biochemistry and imaging techniques including in vitro cell-based functional assays, primary cell cultures, transfection/transduction techniques, CRISPR/Cas9, microscopy, flow cytometry, and other immunoassays.
• Hands-on experience with mouse models of disease, mouse handling, in-life procedures and tissue harvesting are preferred.
• Familiarity with the analysis of large-scale multiomic datasets, such as single-cell and spatial transcriptomics, is preferred.
• Experience developing complex primary cell co-culture systems is an advantage.
• The individual should have demonstrable skills and experience in leading focused hypothesis-driven biological research, as exemplified by quality publications.
• The successful candidate must have demonstrated success in working in a cross-functional and highly collaborative team environment, and must be able to communicate clearly and effectively, both verbally and in writing, to a variety of audiences.

The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives.

For additional benefits information, visit:

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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