Senior Scientist, Data (AI) Scientist, Translational Safety

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.comAs guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.Job Function: Data Analytics & Computational SciencesJob Sub Function: Data ScienceJob Category:Scientific/TechnologyAll Job Posting Locations:Cambridge, Massachusetts, United States of America, Horsham, Pennsylvania, United States of America, New Brunswick, New Jersey, United States of America, Raritan, New Jersey, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of AmericaJob Description:About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.Learn more at Position SummarySenior Scientist – Data (AI) Scientist, Translational Safety to join the Data, Data Science & Artificial Intelligence (DDSAI) – OCMO (Office of Chief Medical Officer) organization helping accelerate drug safety prediction across all stages of drug discovery and development, using advanced AI/ML analytics and multimodal modeling of biological (preclinical and clinical) and RWE data. The Senior Translational AI Scientist will develop predictive models that identify translational-biomarkers and flag compounds with high translational-safety risk, enabling optimal risk minimization supporting patient benefit/risk decisions. One exciting opportunity will be to support the development of AI-enabled reasoning capabilities and Foundation models that connect discovery, preclinical, clinical, and real-world evidence domains to accelerate translational safety predictions. This role will partner closely with pharmaceutical scientists across all phases as well as other Data Scientists from Knowledge Engineering and Data Products to transform harmonized, AI-ready data assets into actionable scientific insights that improve decision-making across the R&D lifecycle.MissionDevelop scientifically credible AI and machine learning capabilities and models that enable earlier prediction of safety and efficacy outcomes and support closed-loop learning across drug discovery and development.Strategic rationale (why this role matters)Builds the capability for AI-driven, translationally-focused predictive models that identify safety biomarkers and flag high translational-risk compounds earlier in the R&D lifecycle in the forward direction, and also support reverse-translation of AE (Adverse event) Signals from RWE by feeding back causal inference insights to preclinical and clinical.Directly supports faster, evidence-based go/no‑go and risk‑minimization decisions, increasing program productivity and protecting patient safety.Enables development of cross-domain Foundation models and AI reasoning that connect discovery preclinical clinical RWE, creating reusable IP and accelerating future projects.Key responsibilitiesDesign, build, validate and deploy AI/ML solutions for translational safety prediction using multimodal data across discovery, preclinical, clinical and real‑world evidence (RWE) domains.Develop predictive models and AI‑reasoning frameworks for translational safety, biomarker identification, mechanistic inference and clinical outcome prediction; evaluate traditional ML, deep learning, causal inference and foundation‑model approaches.Integrate heterogeneous, high‑dimensional datasets (e.g., high‑content imaging, phenomics, transcriptomics, proteomics, EHR, claims) to derive novel biological insights that de‑risk safety signals and inform portfolio decisions.Establish scientific validation: assess biological plausibility, benchmark model performance, produce explainability and validation packages suitable for regulatory and cross‑functional review.Prototype and advance Foundation‑model connectors and AI‑enabled reasoning to link discovery preclinical clinical RWE and support closed‑loop learning across R&D.Collaborate closely with translational scientists, toxicology, clinical safety, PV, Knowledge Engineering, Data Products and external partners to prioritize use cases, operationalize models and drive productization.Communicate complex technical methods and results clearly to diverse audiences and stakeholders; maintain reproducible code, documentation and up‑to‑date versioned repositories.QualificationsEducation: Ph.D. preferred in Computational Biology, Bioinformatics, Biomedical Informatics, Computer Science, Statistics, Applied Mathematics or a related quantitative discipline; or equivalent experience.Experience: demonstrated experience applying AI/ML in life‑sciences settings (industry or post‑doc); typically 2+ years post‑PhD or ~3–5 years relevant industry experience.Domain expertise: track record in translational science, biomarker discovery, safety assessment or related drug‑discovery applications. Publication history or demonstrated contributions to top‑tier conferences/journals preferred.Technical skills:Strong programming proficiency, preferably Python, and experience with AI frameworks (PyTorch or TensorFlow).Deep knowledge of ML/DL methods (Transformers, CNNs, graph networks, self‑supervised and multi‑instance learning), causal inference and graph analytics.Experience with multimodal representation learning, foundation models, LLMs/GraphRAG and multimodal data fusion.Practical experience analyzing imaging/microscopy, multi‑omics and real‑world clinical data at scale.Capabilities & behaviors: excellent analytical thinking, scientific rigor, strong written and oral communication, collaborative cross‑functional influence, and the ability to translate domain questions into robust AI solutions.Nice‑to‑have: prior experience producing regulatory‑acceptable model evidence, operationalizing models into decision workflows, or building reusable model assets for R&D programs.Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource.#LI-GR #LI-Hybrid #JRDDS #JNJDataScience #JRD Required Skills:Preferred Skills:Advanced Analytics, Business Intelligence (BI), Coaching, Collaboration, Critical Thinking, Data Analysis, Database Management, Data Privacy Standards, Data Reporting, Data Savvy, Data Science, Data Visualization, Econometric Models, Process Improvements, Technical Credibility, Technologically Savvy, Workflow AnalysisThe anticipated base pay range for this position is :$109,000.00 - $174,800.00Additional Description for Pay Transparency:Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:Vacation –120 hours per calendar yearSick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar yearHoliday pay, including Floating Holidays –13 days per calendar yearWork, Personal and Family Time - up to 40 hours per calendar yearParental Leave – 480 hours within one year of the birth/adoption/foster care of a childBereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar yearCaregiver Leave – 80 hours in a 52-week rolling period10 daysVolunteer Leave – 32 hours per calendar yearMilitary Spouse Time-Off – 80 hours per calendar yearFor additional general information on Company benefits, please go to: - Spring House, Pennsylvania, United States of America; Horsham, Pennsylvania, United States of America; New Brunswick, New Jersey, United States of America; Cambridge, Massachusetts, United States of America; Raritan, New Jersey, United States of America; Titusville, New Jersey, United States of AmericaType: Full time