Scientist III, Bioinformatics

Work Schedule Standard (Mon-Fri) Environmental Conditions Office Job Description As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier, cleaner and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the world’s toughest challenges, like protecting the environment, making sure our food is safe, or helping find cures for cancer. Discover Impactful Work As part of the Bioinformatics R&D team within the Clinical Next Generation Sequencing Division you will support primer design and the development of targeted sequencing panels, as well as building pipelines and algorithms for next-generation sequencing (NGS). As a leader in life science technologies, our team empowers scientists to harness genomics to drive scientific discovery and advance clinical research in personalized medicine. Location This is a fully onsite role based in Carlsbad, CA or South San Francisco, CA. A Day in the Life Design assays for custom targeted sequencing panels for external and internal researchers Understand key scientific questions and translate them into effective assay design strategies Partner with external customers to understand project requirements and deliver high-quality design solutions that meet their needs Collaborate cross-functionally with molecular biologists, product management, and other bioinformatics and software team members to support new product development, launch, troubleshooting, and optimization Develop, maintain, and operate bioinformatics pipelines for assay design, data mining and analysis Improve assay designs through iterative analysis of sequencing data and development of heuristics, optimization methods, and algorithms Evaluate, implement, and scale new technologies and methods to optimize and automate pipelines for primer design Keys to Success Education PhD in bioinformatics, statistics, genomics, computational biology, computer science or related field; or MS with 3+ years of relevant industry experience Experience Proficiency in Python and shell scripting Hands-on experience with bioinformatics production systems Experience with targeted NGS sequencing, Ampliseq technology or PCR primer design is highly preferred Experience with sequence analysis tools (BLAST, MAFFT/Clustal, Bowtie/BWA, samtools/bedtools) and strong understanding of genomic databases and annotations (GenBank/RefSeq, ENSEMBL, UCSC) Working knowledge of statistical modeling, optimization, or machine learning applied to genomic or assay-design data Experience applying modeling or machine learning approaches to support assay performance prediction, off-target assessment, QC flagging, or design-rule optimization is preferred Knowledge, Skills, Abilities Excellent communication and organizational skills Self-motivated, collaborative, and detail-oriented Strong problem-solving and troubleshooting skills Commitment to delivering high-quality results with integrity and professionalism Other Must be legally authorized to work in the United States without sponsorship now or in the future Must be able to pass a comprehensive background check and drug screen Compensation and Benefits The salary range estimated for this position based in California is $95,900.00–$127,800.00. This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes: A choice of national medical and dental plans, and a national vision plan, including health incentive programs Employee assistance and family support programs, including commuter benefits and tuition reimbursement At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount For more information on our benefits, please visit: Thank you for your interest as you consider starting a new career journey with us. As the world leader in serving science, our colleagues develop critical solutions through innovation—and build rewarding careers. Discover their extraordinary stories and connection to our Mission to enable our customers to make the world healthier, cleaner and safer. Their work is a story of purpose. What story will you tell? Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Thermo Fisher Scientific is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, creed, religion, color, national or ethnic origin, citizenship, sex, sexual orientation, gender identity and expression, genetic information, veteran status, age or disability status.