Postdoctoral Research Fellow, Anesthesiology

Position Overview This Postdoctoral Fellow position is essential for the successful execution of a highly technical, multi‑aim translational research project focused on uncovering immune mechanisms underlying chemotherapy‑induced peripheral neuropathy (CIPN) in the context of breast cancer treatment. The proposed research integrates complex orthotopic tumor models, immune‑specific genetic manipulations, advanced neurobehavioral phenotyping, and translational pharmacologic interventions, and requires a dedicated, full‑time postdoctoral scientist with advanced methodological and analytical expertise. PhD or equivalent required. Responsibilities Experimental Design and Execution Lead and coordinate immunocompetent, orthotopic breast cancer resection models combined with adjuvant chemotherapy. Execute complex longitudinal CIPN behavioral assays (mechanical allodynia, cold sensitivity). Perform immune‑specific genetic and pharmacologic manipulations targeting the IRE1α XBP1 pathway. Conduct advanced flow cytometry, FACS sorting, molecular assays (qPCR, ELISA), histology, and confocal imaging. Mechanistic and Translational Integration Integrate tumor progression endpoints (recurrence, lung metastases, IVIS imaging) with neurotoxicity and immune outcomes. Perform ex vivo co‑culture assays linking immune cell activation to neuronal injury and tumor aggressiveness. Evaluate translational pharmacologic strategies (MKC 8866 ± paclitaxel) across multiple disease contexts. Data Analysis, Interpretation, and Dissemination Analyze high‑dimensional data across behavioral, molecular, immune, and oncologic endpoints. Prepare manuscripts, conference presentations, and progress reports for funding agencies. Contribute to grant development supporting continuation and expansion of the research program. Research Training and Mentorship Provide day‑to‑day mentorship to trainees (graduate students and research staff) in specialized techniques. Foster cross‑disciplinary collaboration between cancer biology, immunology, neuroscience, and anesthesiology. Qualifications PhD or equivalent required. Compensation and Benefits Pay Range: $30.70 – $46.05 per hour. Base compensation within the listed pay range based on qualifications, skills, relevant experience, and/or training. Premium pay such as shift, on‑call, and other additional compensation based on job responsibilities. Incentive pay for select positions. Opportunity for annual increases based on performance. Benefits include: Paid Time Off programs. Health and welfare benefits such as medical, dental, vision, life, and short‑ and long‑term disability. Flexible Spending Accounts for eligible health care and dependent care expenses. Family benefits such as adoption assistance and paid parental leave. Defined contribution retirement plans with employer match and other financial wellness programs. Educational Assistance Program. Eligibility for programs listed above may depend on your full‑time employment status. Please ask a recruiter for more information during the interview process. #J-18808-Ljbffr Advocate Aurora Health