Postdoctoral Associate (Cancer)

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The University of Miami/UHealth Department of SCCC has an exciting opportunity for a full time Postdoctoral Associate to work at the UHealth medical campus in Miami, Fl.

CORE JOB SUMMARY
The Postdoctoral Associate performs scientific research and studies under the supervision of managing staff. Moreover, the Postdoctoral Associate promotes institutional recognition through literal contributions to the
scientific community.

CORE JOB FUNCTIONS
1. Conducts research on specific areas of study as assigned.
2. Prepares research reports and technical papers for publishing.
3. Investigates the feasibility of applying a wide variety of scientific principles and theories.
4. Maintains substantial knowledge of state-of-the-art principles and theories.
5. Develops advanced analytical models and systems and provides solutions and analyses to support
strategic and tactical decisions.
6. Adheres to University and unit-level policies and procedures and safeguards University assets.
This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary.

CORE QUALIFICATIONS
Education: Ph.D. in relevant field
Experience: No prior experience required

Knowledge, Skills and Attitudes:
• Skill in collecting, organizing, and analyzing data.
• Ability to recognize, analyze, and solve a variety of problems.
• Ability to exercise sound judgment in making critical decisions.

DEPARTMENT SPECIFICS:

We are accepting applications for a Postdoctoral Research Associate in Dr. Stephen Nimer’s lab at the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine (Miami, Florida) to investigate the molecular mechanisms of epigenetic regulation of cancer, with particular focus on normal and malignant hematopoiesis. The Nimer laboratory has been studying the transcriptional regulation of hematopoiesis for decades, with the aim of understanding how the normal processes of stem cell self-renewal and differentiation are regulated and how these processes are aberrantly regulated in hematological malignancies. The laboratory currently focuses on studying the contribution of epigenetic modifications and chromatin changes to the development of these diseases and aims at identifying novel therapeutic targets and novel approaches to making cancer cells more responsive to treatment.

We are seeking highly motivated individuals to develop and implement innovative computational approaches for analyzing high throughput genomic and epigenomic data, including but not limited to, integrated cancer risk prediction model, cancer subtype discovery, genomic and epi-genomic data integration, single cell RNA-Seq data analysis, non-coding RNA data analysis, and other datasets. Projects will include next-generation sequencing based profiling studies of RNA-Seq, ChIP-seq, HiC-Seq, ATAC-Seq, etc…to fully characterize epigenetic changes involved in the development of hematologic maligancies. The goal of these studies is to identify epigenetically regulated programs that become deregulated and contribute to the development of these diseases. Applicants should hold a PhD and/or MD degree and have strong computational biology skills. Previous experience with epigenome-wide assays is preferred. The successful candidate will be working in a collaborative environment with multiple faculty members, biostatisticians and bioinformaticians on translational cancer research.

DUTIES & RESPONSIBILITIES:

We are seeking highly motivated individuals to develop and implement innovative computational approaches for analyzing high throughput genomic and epigenomic data, including but not limited to, integrated cancer risk prediction model, cancer subtype discovery, genomic and epi-genomic data integration, single cell RNA-Seq data analysis, non-coding RNA data analysis, and other datasets. Projects will include next-generation sequencing based profiling studies of RNA-Seq, ChIP-seq, HiC-Seq, ATAC-Seq, etc…to fully characterize epigenetic changes involved in the development of hematologic maligancies. The goal of these studies is to identify epigenetically regulated programs that become deregulated and contribute to the development of these diseases. Applicants should hold a PhD and/or MD degree and have strong computational biology skills. Previous experience with epigenome-wide assays is preferred. The successful candidate will be working in a collaborative environment with multiple faculty members, biostatisticians and bioinformaticians on translational cancer research.

KNOWLEDGE SKILLS AND ABILITIES:

Solid training in quantitative sciences Sound knowledge of statistics and R/ Bioconductor Experience with next-generation sequencing (NGS) data analysis Understanding of epigenome biology Solid programming skills in scripting and/or compiled languages Familiarity with Linux/Unix environment and compute clusters Strong oral and written communication skills Good organizational, communication and interpersonal skills. The ability to work both independently and in a team environment Ability to write manuscripts independently

EDUCATION & EXPERIENCE:

Ph.D. in Bioinformatics, Computational Biology, Biostatistics, Statistics, Genetics, Computer Science, or a related field. Excellent communications skills in English (both verbal and written). Proficiency in using R/Bioconductor and Perl/Python for genomic data analysis is required.

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The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

The University of Miami is an Equal Opportunity Employer. Applicants and employees are protected from discrimination based on certain categories protected by Federal law.

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