Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Senior Staff Machine Learning Software Engineer

$202k - $215k

San Diego Stealth Startup

Job Description

Job Description

Location: San Diego, CA

Job Type: Full-Time

Salary Range: $202,000 – 215,000

Position Overview

We are building a product where learned models and compute-heavy inference components have to run inside a tight local runtime budget. Research code is only the starting point. This role owns the path from a working prototype to production inference that is measured, packaged, tested, and ready for repeated use in the field.

You will work closely with the people developing the underlying algorithms, but your ownership is different: production readiness, performance, reliability, and the engineering boundary between exploratory model work and shipped execution. The strongest fit is someone who can explain the bottleneck they found, the number they moved, the tradeoff they accepted, and the test that kept the fix from regressing.

If your best work is making inference faster, smaller, more predictable, and easier to ship, this role is likely a good match.

Responsibilities

  • Turning research prototypes into production inference components with explicit latency, throughput, memory, and accuracy budgets
  • Optimizing the execution path: tensor layout, host/device transfers, batching strategy, kernel launch overhead, mixed precision, quantization, and memory reuse
  • Writing or tuning Rust, C++, and CUDA where framework-level optimization is not enough, then validating the improvement with profiler output and release-facing tests
  • Building inference-adjacent evaluation machinery: calibration checks, confidence behavior, regression detection, dataset slices, and failure-mode reporting tied to product metrics
  • Maintaining the deployment contract: model artifacts, runtime integration, versioning, reproducibility, and performance gates that block unsafe changes
  • Algorithm research and novel model design live on a separate track. You will collaborate with that team, translate prototypes into production constraints, and surface shipping risks early when a design needs to change.

Qualifications

  • PhD (6+ years), MS (10+ years) or BS/BA (12+ years) of experience in life sciences or technology.
  • Must have demonstrated leadership or ownership with 2 of the 5 areas referenced below successfully:
  • Shipped constrained inference. You have personally moved a model or learned component from prototype to deployed runtime with a real latency, throughput, memory, or power budget. You can name the target, the bottleneck, and the change that closed the gap.
  • Rust/C++ at shipping depth. You have written production code in Rust or modern C++ where correctness, latency, memory layout, and ownership boundaries mattered. You can reason about the runtime behavior of the code you ship, not just its API surface.
  • CUDA and accelerator-aware execution. You are comfortable below Python: custom CUDA extensions or kernels, host/device memory movement, launch overhead, profiler traces, and the practical tradeoffs between framework convenience and a purpose-built implementation.
  • Performance-native judgment. You reason in wall-clock time, memory movement, launch overhead, bandwidth, numerical precision, and error budgets without needing those constraints added late in review.
  • Production engineering discipline. You define typed interfaces, deterministic behavior, reproducible artifacts, meaningful tests, and clean handoffs with upstream research code.

Strongly Preferred

  • Rust at shipping depth, especially FFI boundaries, pyo3 / maturin, async runtimes, or performance-sensitive service code
  • Inference on constrained local hardware, embedded systems, edge devices, or budget-bound accelerator deployments
  • Quantization, mixed precision, model compression, or kernel fusion that shipped beyond a benchmark notebook
  • Calibration or confidence estimation used on production outputs, with monitoring or regression checks attached
  • Public or shareable evidence of engineering quality: code, technical writing, postmortems, talks, or a concrete shipped system you can discuss
  • Comfort using AI-assisted development tools while still owning correctness, tests, and review quality

Nice to Have

  • Real-time or near-real-time signal-processing systems
  • Products that combine learned models with deterministic numerical code
  • Rust- or C++-based inference or numerical pipelines, including custom FFI to CUDA, cuDNN, TensorRT, or similar accelerator libraries

We are an equal opportunity employer. We thrive on diversity and collaboration.

Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Senior Staff Machine Learning Software Engineer in San Diego, CA vacancy
  • $110k - $180k

    The Marlin Alliance, Inc. is seeking a Senior Machine Learning Engineer to design, develop, and implement advanced machine learning models and algorithms...  ..., distributed systems, cloud-native development, and software engineering best practices. The Senior ML Engineer will... 
    Senior
    Contract work

    The Marlin Alliance

    San Diego, CA
    4 days ago
  •  ...AppFolio in San Diego is seeking a Senior Machine Learning Engineer to design and ship the next generation of voice and conversational AI agents within Realm-X. This role focuses on defining production voice and chat agent pipelines, working at the intersection of LLM... 
    Senior

    AppFolio

    San Diego, CA
    2 days ago
  •  ...Apple is seeking an outstanding software engineer to architect and develop innovative algorithms and infrastructure for the next generation of thoughtful and personal Photos experiences and Apple Intelligence features across iPhone, iPad, macOS, and Vision Pro. You will... 
    Senior

    Socket

    San Diego, CA
    1 day ago
  • $180k - $250k

     ...Role: Senior Machine Learning Engineer Location: San Diego, CA (in-office) Salary Range: $180,000 - $250,000 / yr + stock options, 401k matching...  ...experiments while collaborating closely with the vehicle software team to integrate your work into the larger stack. On... 
    Senior
    Permanent employment
    Full time
    Work at office
    Local area
    Remote work
    Flexible hours

    Seasats

    San Diego, CA
    a month ago
  • $140k

     ...sensors — and wherever accuracy matters, you’ll find Sensoride at the center. Why Consider This Job Opportunity The Senior Machine Learning Engineer works on meaningful, real-world challenges where machine learning directly impacts the performance of automotive... 
    Senior
    Flexible hours

    Murata America

    San Diego, CA
    11 days ago
  • A technology solutions company seeks a Systems Engineer with secret clearance to work full-time from Coronado, CA. The role involves supporting the design and implementation of integrated data, application, and AI/ML ecosystems. Responsibilities include guiding engineering... 
    Senior
    Full time

    EurekaFacts

    Coronado, CA
    1 day ago
  • $206k - $282k

    Foster City, CA / San Diego, CASoftware - Software Platforms and Product /Full-time /HybridAs a Firmware Connectivity Systems Integration...  ...Zoox’s connectivity systemsQualificationsM.S. in Electrical Engineering, Telecommunications, or a similar discipline with 8+ years of... 
    Senior
    Full time
    Temporary work
    Relocation package

    Zoox

    San Diego, CA
    5 days ago
  • $166k - $208k

     ...matrixed, cross-functional environmentEducationBachelor’s Degree in Engineering, Business, or a related fieldAdditional InformationThe...  ...the sole discretion of Renesas.SummaryType: Full-timeFunction: MarketingExperience level: Mid-Senior LevelIndustry: Semiconductors
    Senior
    Local area
    Remote work

    Renesas Electronics America

    San Diego, CA
    3 days ago
  • $78k - $156k

     ...than 160 countries.JOB DESCRIPTION:Position OverviewThe Sr. Machine Learning Engineer, with minimal guidance from more experienced engineers,...  ...with other ML/AI engineers and relevant partners to design software solutions that utilize state-of-the art artificial intelligence... 
    Senior
    Shift work
    Night shift

    Abbott

    San Diego, CA
    6 days ago
  •  ...changemakers, and collaborators. We're more than just a software company — we're building the AI-native platform where the...  ...and decision-making. Who We Are Looking For We're hiring a Senior Machine Learning Engineer to design and ship the next generation of voice and... 
    Senior
    Full time
    Flexible hours

    AppFolio

    San Diego, CA
    4 days ago
  • $57.13k - $68.26k

    UCSD Layoff from Career Appointment : Apply by 08/31/2026 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor. Reassignment Applicants : Eligible Reassignment clients should contact their Disability Counselor...
    Senior
    Hourly pay
    Full time
    Part time
    Flexible hours

    UC San Diego

    San Diego, CA
    14 hours ago
  • $156.4k - $211.6k

     ...We are looking for a software engineering leader who is passionate about creating next-generation...  ...regulated industry. Additionally, the Senior Principal Software Engineer will bring...  ...in some key areas like architecture. Learn and use Go and potentially other back-end... 
    Senior
    Full time
    Temporary work
    Local area
    Flexible hours

    Tendo

    San Diego, CA
    14 hours ago
  •  ...want to hear from you. As we grow, we are looking for a Senior Software Engineer to join our Platform team and help build the core infrastructure...  ...direct impact on our product and company trajectory. Learning & Development : Gain deep expertise in financial... 
    Senior
    Full time

    Stealth Fintech

    San Diego, CA
    14 hours ago
  • Bachelor's degree in Engineering, Information Systems, Computer Science, or related field and 2+ years of Software Engineering or related work experience. OR Master's degree in...  ...with setbacks in a timely manner. Seeks out learning opportunities to increase own knowledge... 
    Senior
    Full time
    Work experience placement

    Qualcomm

    San Diego, CA
    14 hours ago
  • $150k - $215k

     ...people. Vannevar is a small agile team combining world-class engineers with veteran strategists who bring deep expertise in defense and...  ...At Vannevar we’re consistently iterating on AI-enabled software products to deter our adversaries and lead the fight for strategic... 
    Senior
    Full time
    For contractors
    Remote work
    Relocation

    Vannevar

    San Diego, CA
    14 hours ago
  • $180k - $195k

     ...Job Description Job Description Senior Staff Systems Architect – Data Quality Location...  ...with a diverse group of scientists and engineers to ensure that the system generates the...  ...challenges involving hardware, software, biology, and informatics using a data-... 
    Senior
    Full time

    San Diego Stealth Startup

    San Diego, CA
    2 days ago
  • $165k - $195k

     ...Marlin Alliance, Inc. is seekinga talented and experienced Senior Machine Learning Engineer to join our team. The successful candidate will be...  ...methods, distributed systems, cloud-native development, and software engineering best practices. The Senior ML Engineer will collaborate... 
    Senior
    Contract work
    Work at office

    The Marlin Alliance, Inc.

    San Diego, CA
    more than 2 months ago
  • $155k - $175k

     ...We are looking for an experienced and ambitious instrument control software engineer to join our instrument software team. We are developing advanced life science research instruments that combine precision hardware control, imaging, and automation. Our software is at... 
    Senior
    Permanent employment
    Full time
    Temporary work
    Visa sponsorship
    Flexible hours

    Quantum-si Incorporated

    San Diego, CA
    14 hours ago
  • Description SAIC is hiring for a Senior Software Engineer who must be experienced in the full development life cycle using modern methodologies, such as Agile/Scrum and test-driven development. Ideal candidate will be experienced with complex coding in C++, CLI, C#, Java... 
    Senior

    Science Applications International Corporation

    San Diego, CA
    3 days ago
  • $143k - $179k

    We are seeking a Senior Software Engineer to join a new product engineering team being built in San Diego, developing software for providers in...  ...to non-technical stakeholders.A demonstrated eagerness to learn and share knowledge with others.What We ValueEngineers who... 
    Senior
    Full time
    Temporary work
    Work experience placement
    Flexible hours

    ResMed

    San Diego, CA
    6 days ago
  •  ...Resources in the San Diego area is seeking a Sr. Principal DevOps Engineer with a high level of autonomy and impact. The role is hybrid on...  ...-cloud environments. The ideal candidate has 10 years in software engineering, expert Kubernetes/Docker, strong scripting (Python... 
    Senior

    Jobleads-US

    San Diego, CA
    2 days ago
  •  ...connectivity ecosystem, including XCOM RAN, its software‑defined private wireless platform...  ...optimize throughput. The solution is engineered for mission‑critical environments where...  ...RAN by Globalstar As a Principal / Senior Staff Software Engineer, you will lead a high... 
    Senior
    Temporary work
    Work at office

    Socket.dev

    San Diego, CA
    2 days ago
  • $160k - $240k

     ...products include Hivemind autonomy software, V-BAT and X-BAT aircraft,...  ..., hardware, and test engineering to solve some of the hardest...  ...customers.About the Job:As a Senior Software Engineer, you’ll build...  ...solving skills and ability to learn new technologies in a fast-paced... 
    Senior
    Full time
    Temporary work
    Part time
    Worldwide

    Shield AI

    San Diego, CA
    5 days ago
  •  ...with deep expertise in Microsoft 365 consolidations, tenant migrations, and government compliance work including GCC High and CMMC. Engineers here work project to project, not ticket queue to ticket queue, alongside project managers and architects on application... 
    Senior
    Weekend work

    Agile IT

    San Diego, CA
    14 days ago
  • $140k - $200k

     ...desk, on the go, at your own speed, and with tools that make learning easier, deeper, and faster. What streaming services have...  ...exponential growth. Overview We're looking for a Senior Software Engineer to join our Core Experiences Team. This team builds and maintains... 
    Senior
    Full time
    Remote work

    Mission Speechify

    San Diego, CA
    14 hours ago
  • $140.8k - $211.15k

    Job SummaryJoin Insulet, the maker of Omnipod and a leader in tubeless insulin delivery. We're seeking a Senior iOS Software Engineer to help build the next generation of life-changing diabetes management solutions.In this role, you'll collaborate with a talented global... 
    Senior
    Full time
    Work at office
    Local area

    Insulet Corporation

    San Diego, CA
    3 days ago
  • $129k - $205k

    Job TitleSenior Software Engineer - AM&D ECG Solutions (San Diego, CA)Job DescriptionSenior Software...  ...Heart, R&D organization. As a Senior Software Engineer, you’ll be a part of...  ...life to help improve the lives of others.Learn more about our business.Discover our rich... 
    Senior
    Full time
    Work at office
    Immediate start
    Relocation package
    3 days per week

    Philips

    San Diego, CA
    3 days ago
  •  ...Seattle, WA / San Diego, CASoftware - Software Platforms and Product /Full-time /...  ...mission, and we’re looking for a Senior/Staff Software Engineer to be a technical leader in this critical...  ...at the intersection of robotics, machine learning, and design, Zoox aims to provide... 
    Senior
    Full time
    Temporary work
    Remote work
    Relocation package

    Zoox

    San Diego, CA
    3 days ago
  • $177.3k - $265.9k

     ...name synonymous with entertainment excellence and creativity.Senior Software Engineer (Frontend), SocialLocation: San Diego, CA (Rancho Bernardo)...  ...skills in a team environment.Proven ability to learn quickly and tackle new challenges.Works independently with... 
    Senior
    Relocation

    Sony Interactive Entertainment America

    San Diego, CA
    3 days ago
  • $163.2k - $244.8k

     ...with intelligent systems. Its products include Hivemind autonomy software and V-BAT and X-BAT aircraft. With offices and facilities...  ...real hardware—for U.S. and international defense customers. Our engineers write new autonomy code—such as mission behaviors, platform-specific... 
    Senior
    Full time
    Temporary work
    Part time
    For contractors
    Work at office
    Worldwide

    Shield Ai

    San Diego, CA
    14 hours ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Senior Staff Machine Learning Software Engineer. Be the first to apply!