Preclinical Scientist

Role Overview Legend Biotech is seeking a Preclinical Scientist as part of the Research and Early Development team based in Somerset, NJ . This position will perform preclinical IND-enabling pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have experience in immunology or immune-oncology to assist preclinical cell therapy studies from discovery to first-in-human trials, and through marketing authorization. Furthermore, the successful candidate will work in a collaborative environment , and would be skillful in driving multiple projects by contributing to the development of cell-based immunotherapies. Key Responsibilities Develop and validate assays to support diverse projects from lead optimization to the conduct of preclinical pharmacology and toxicology studies for regulatory submission. This includes, designing, optimizing, and implementing IND-enabling studies, contributing to the creation, review, and approval of prospective standard operating procedures, executing in vitro and in vivo IND-enabling studies, recording all experiments in an electronic laboratory notebook, reporting any deviations, analyzing and reporting processed data in the form of a study report. Design and support in vitro IND-enabling studies to assess efficacy and safety of cell therapies. Support the preparation of scientific and regulatory documents of IND-enabling preclinical studies. The Preclinical Scientist will work independently reporting directly to the Director of Preclinical Pharmacology and Toxicology. The Preclinical Scientist will demonstrate competency and professionalism especially as it pertains to using the scientific method to design, execute, and troubleshoot in vitro laboratory experiments. Requirements BS plus 5 years of experience, MS plus 3 years of experience. Work experience in immunology, cancer biology or related fields. Knowledge and expertise in immune-oncology of large molecules or cell therapy is a plus. Strong scientific background with hands on experience in cellular and molecular biology techniques (e.g., flow cytometry, ELISA, cell culture and cytotoxicity assays, qPCR, Western Blot and others). Demonstrated track record of scientific contributions in peer-reviewed journals and symposia. Ability to manage multiple programs in parallel while delivering on key milestones. Knowledge of GLP and regulatory agencies is a plus. Ability to multi-task in a fast-paced, highly collaborative diverse team environment. Benefits Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech. EEO Statement It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances. #J-18808-Ljbffr Legend Biotech USA