On-site Structural Biologist: Cryo-EM & X-ray Expert

Kelly Government Solutions is a strategic supplier and business partner to the federal government and its key suppliers. We have multiple openings for Structural Biologists to work on-site at the National Institutes of Health in Bethesda, MD. This is a long-term contract position which offers: Competitive compensation and comprehensive benefit package Optional health, vision, and dental plans Paid leave as well as 11 paid federal holidays and 401K plan. Access to NIH’s unparalleled resources and niche scientific initiatives

KEY TASKS

• 1) Process and analyze structural datasets, including but not limited to cryo-electron microscopy (cryo-EM) and X-ray crystallography data
• 2) Provide scientific, technical, and operational support for the cryo-electron microscopy (cryo-EM) facility including Titan Krios and other electron microscopes.
• 3) Support structural biology research through high-quality cryo-EM data acquisition and analysis
• 4) Perform high-throughput cryo-EM data collection and screening of samples
• 5) Optimize data acquisition strategies for resolution, throughput, and efficiency.
• 6) Conduct specimen preparation, vitrification, and grid screening for cryo-EM studies.
• 7) Perform computational processing of cryo-EM and negative-stain datasets.
• 8) Support image analysis, structural models, 3D reconstruction, and data interpretation.
• 9) Apply antigen design and protein engineering tools to support scientific research projects
• 10) Perform in vitro biochemical and biophysical assays to evaluate proteins and constructs
• 11) Develop, implement, and document standard operating procedures (SOPs) for structural prediction, protein design, and data visualization
• 12) Train users in cryo-EM specimen preparation, microscope operation, and data collection
• 13) Provide consultation to investigators on experimental design and feasibility
• 14) Develop and implement new cryo-EM methodologies and workflows.
• 15) Contribute to the preparation of manuscripts, presentations, and other scientific communications and support development of graphical or 3D representations of structural data

REQUIREMENTS

• 1) Ph.D. in Structural Biology, Biochemistry, Biophysics, Computational Biology, or a closely related biomedical field
• 2) Minimum of four (4) years of relevant experience including structural biology
• 3) Demonstrated expertise in structural biology methods and techniques, including cryo-electron microscopy (cryo-EM) and/or X-ray crystallography
• 4) Experience performing structural analysis and modeling of viral glycoproteins preferred

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