Associate Scientist II/Scientist I - Chemical Biology & Mass Spectrometry Technologies

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Job Description

This position requires a BSc / MSc level scientist to maximize the impact and productivity of the Chemical Biology and Mass Spectrometry and Technologies (CB&MST) team for generation of data to drive pipeline decisions. This scientist will work collaboratively with team members to transition routine, low throughput sample preparation procedures for target validation, target engagement, and off-target profiling into high precision / high throughput procedures with a focus in proteomics preparation methodologies and plate-based proteomics sample prep. The successful candidate will collaborate with teammates to optimize and perform automated sample preparation methodologies and conduct mass spectrometry-based proteomics experiments to enable this transformation.

Key Responsibilities:

• Work with team members to develop, validate, and implement automated sample preparation workflows for CB&MST activities, with an emphasis on plate-based proteomics sample preparation using cell lines, tissues and other biological matrices.
• Develop methods to automate chemical biology sample prep using magnetic bead-based enrichments and liquid handling.
• Collaborate with team members to establish, document, and maintain Standard Operating Procedures for routine workflows.
• Operate, monitor, and assist with the maintenance and troubleshooting of LC-MS instrumentation and associated laboratory equipment.
• Assist with data processing, quality assessment, and data interpretation.
• Interface and collaborate with colleagues and project teams in therapeutic areas to determine appropriate samples and amounts required for studies.

Qualifications

Basic:

• Bachelors or Masters in chemistry, biochemistry, chemical biology or related field with typically 3-5+ (BS), or 0-2+ (MS) years of experience.
• Hands-on bench skills for preparing samples for mass spectrometry, with a focus in proteomics sample preparation from cell lines and tissues.
• Ability to generate proteomics samples in 96-well plates and run samples on LC-MS instrumentation.
• Ability to work proficiently with laboratory equipment typically found in a chemical biology, biochemistry, or molecular biology laboratory.
• Demonstrated ability to troubleshoot and diagnose problems with common laboratory equipment.

Preferred:

• Experience utilizing LC/MS for proteomics including current models of Thermo and Bruker mass spectrometers.
• Experience with automation such as the Agilent Bravo, Thermofisher KingFisher, and Opentrons Flex.
• Ability to conduct different types of proteomics experiments including whole proteomics, phosphoproteomics immunoprecipitation proteomics, and targeted MS, etc.
• Experience in basic biochemistry and molecular biology techniques including plate-based assays, SDS-PAGE, western blotting, and mammalian tissue culture is desired.
• Ability to conduct bead- and probe-based chemical biology experiments that utilize proteomics as a readout.
• Ability to effectively use AI to increase personal and team productivity.

Key Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast, grasps the 'essence' and can change the course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures, and manages innovation to reality.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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