Scientist R&D - Immunohistochemistry (IHC) & Histology

Natera seeks a scientist to develop and optimize immunohistochemistry and histology workflows for oncology product development. The role involves assay design, validation studies, and cross-functional collaboration to translate research methods into clinical laboratory processes.

Responsibilities

• Design and execute development, optimization, verification, and validation studies for IHC and tissue workflows
• Develop IHC assays including antibody selection, antigen retrieval, staining conditions, and performance assessment
• Evaluate and optimize histology and pre-analytical variables including tissue processing and slide preparation
• Troubleshoot automated staining platforms and investigate artifacts, reagent performance, and assay variability
• Author protocols, validation reports, SOPs, and provide technical guidance during method transfer to clinical operations

Requirements

• Ph.D. in Pathology, Cancer Biology, Molecular Biology, or related field with 2+ years industry experience
• Master's degree with 5+ years relevant industry experience, or Bachelor's with 6-8+ years
• Hands-on expertise in IHC assay development, optimization, and troubleshooting
• Solid knowledge of histology and FFPE tissue workflows
• Experience with antibody characterization, antigen retrieval, and staining optimization
• Experience with automated IHC/ISH platforms, particularly Roche BenchMark ULTRA
• Proficiency with data analysis tools such as Excel and JMP