Senior Process Engineer, Lilly Medicine Foundry

Job ID: R-108799Company: LillyLocation: Indianapolis, Indiana, United States of AmericaJob Type: Full TimeCategory: EngineeringPosted Date: 2026-08-12At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.About the Lilly Medicine Foundry:Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.Organizational Overview:Lilly is currently constructing an advanced research facility for production of API molecules for clinical trials located in Lebanon, IN. This facility is Lilly’s largest investment in a clinical trial manufacturing capacity and is intended to provide APIs for current and future products, including new modalities. This is a unique opportunity to be a part of the startup team for a greenfield manufacturing site, and the successful candidate will help to build the processes and facility to enable a successful startup into GMP manufacturing operations.  We are seeking a small molecule Process Engineer to support the pilot plant facility in Lebanon with a focus on active pharmaceutical ingredient synthesis. This position involves solving technical challenges with equipment design, developing and sustaining process knowledge, optimizing processes, and managing equipment capabilities.  ResponsibilitiesThe Process Engineer provides technical assessment and support for production operations in the areas of developing and sustaining process knowledge, process and equipment support, process optimization, equipment capability and asset management, and engineering business systems. This role is to serve as a process engineer supporting small molecule drug substance active pharmaceutical ingredient (API) manufacturing.Perform impact and risk assessments for unit operations Learn the lab and plant design for the reactors including automation recipes and procedures.Ensure that people and their environment are safe and that company policies concerning safety are followed.Ensure processing equipment remains compliant with internal Quality System requirements, applicable engineering standards, and cGMP requirements.Assesses rig fit by receiving the technical data package for new processes and performing modeling, simulations and/or experimental work as required to ensure heat and mass transfer are acceptable when scaling to the plant.Active engagement and communication with: HSE, Quality Assurance, Tech Services, Development, Operations, FUME/C&Q, Automation, Maintenance, Environmental Monitoring, and Manufacturing.Author, review, or approve high-quality technical reports and regulatory submissions dealing with the work performed by the department. Ensure that records and technical notebooks are adequately maintained.Demonstrate engagement and employ a quality approach in all endeavors by proactively identifying quality issues and communicating appropriately.Develop or review plans and timetables for project work.Basic Requirements:BS or MS in Chemical Engineering or related engineering degreeMinimum of 2 years of experience within a pharmaceutical, biotech, chemical manufacturing, or CMO environment or other relevant batch manufacturing process.Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.Additional Preferences: Supported manufacturing and/or development activities for active pharmaceutical ingredients, intermediates, or other chemicalsDeep technical interest and understanding in the field of Chemical EngineeringFamiliarity with unit operations including but not limited to chemical reactions, distillation, phase separation, filtration, dryingAbility to work well in a team environment incorporating a variety of functional relationships and desire to be point of accountabilityExperience with any of the following software packages: DeltaV, Dynochem, Aspen, and/or electronic lab notebooksStrong analytical and problem-solving skillsStrong oral and written communication skills for a diverse audience, e.g., both operations staff and management.Ability to work on own initiative and as part of a Process Team consisting of a diverse group of management, production, science and engineering professionalsUnderstanding of process control systemsCreativity to identify improvement opportunities and the tenacity/initiative to see them implementedGuidance/mentoring of others through processes Flexibility to meet business needsOther Information:Initial location at Parkwood West, Indianapolis. Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.#WeAreLillyLilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (View email address on us.fitly.work), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$66,000 - $171,600Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLillySkillsprocess optimizationgmp compliancechemical engineeringequipment designprocess assessmentrisk assessmentprocess modelingprocess simulationtechnical report writingregulatory submissionsquality system complianceprocess control systemsautomation recipeslab designdeltavdynochemaspenelectronic lab notebooksphase separationdistillationfiltrationdryingprocess improvementteam collaborationanalytical skillsproblem solvingoral communicationwritten communication