Senior Reliability Engineer

Overview What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Team & Role The Senior Reliability Engineer within the Strategic Operations team ensures that consumables manufacturing systems in San Diego, CA, are optimally operated and maintained throughout their lifecycle. They support equipment engineer teams through the provision of reliability expertise and services in a fast paced regulated environment and will work in a dynamic team-oriented environment that supports multiple operations and technologies helping Illumina deliver its highly complex product pipeline. Responsibilities Work closely with NPI and Equipment Engineering teams to assess and prepare equipment transfer from development to sustaining. Lead and execute the provision of maintenance dossiers for new equipment containing: Criticality Studies, Turnover Packages, Reliability Centered Maintenance (RCM) studies, Lock-Out/Tag-Out procedures, Maintainability Reviews, CMMS Data Packages, Spares Lists, Special Tools Lists, Measuring Points. Support hands‑on troubleshooting of chronic equipment failures, organize and lead Root Cause Analysis work sessions. Be available and willing to spend time on the manufacturing floor during maintenance and troubleshooting activities. Enable data driven decision making through the collection, cleansing and statistical analysis of failure data. Integrate equipment into the Data Historian (E3) and build alarm and triggers for early detection of failure modes. Generate or sustain work instructions linked to equipment maintenance (PM procedures, Task Lists, Asset Lifecycle Processes, Spare Parts Processes, Planning and Scheduling Processes, Maintenance Strategies…) Sustain the Equipment Spares Program, support materials onboarding activities, set up parts for refurbishment, process Re‑order point (ROP) /Max Stock‑Level (MSL) update requests. Monitor maintenance and spare parts related metrics (Uptime, PM Compliance/Performance, Spares Release TAT, Indirect/Direct procurement). Engage with vendors and sourcing partners to establish service contracts, define scope of support and negotiate technical and commercial terms. Lead or participate in lean initiatives to eliminate waste in engineering processes, lead internalization of maintenance activities where appropriate. Participate in projects initiations, provide inputs to problem statement, scope, benefits, timeline, resource allocation and risks. Act as Reliability SME or project lead, monitor project progress to plan and report‑out. Spearhead improvements to engineering processes. Identify and develop new processes, as needed. Maintain strong positive working relationships with stakeholders, cross‑functional team members, and internal customers. Be a role model in a team environment; continuously push for improved equipment reliability and uptime. Coach and mentor other engineers and technicians, as appropriate. Travel & Physical Demands Travel up to 10%. While performing the duties of this job, is regularly required to stand, sit, walk, climb stairs/ladders, kneel, crouch, or wear safety gear. Must regularly lift and / or move up to 10 pounds, frequently lift and/or move up to 25 pounds, and occasionally lift and/or move up to 50 pounds. Qualifications Bachelors’ degree, 3+ years of experience. Experience in a clinically regulated environment is highly desirable. Work experience in Life Sciences / Pharmaceutical / Medical Devices industries would be an advantage. Six Sigma Green Belt and Controls experience (Beckhoff Twincat, Siemens S7) is a plus. Project Management Experience, certification (PMP, Prince2) is a plus. SQL or Python experience is a plus. Requirements Knowledge of GMP (Good Manufacturing Practice) required. SMRP Certified Maintenance & Reliability Professional (CMRP) is nice to have. Six Sigma Belt certification strongly preferred. CRL certification is nice to have. Familiarity in the operation and maintenance of one or multiple of the following equipment: Fill‑Finish, Semi‑Conductor, Analytical, alternatively, demonstrable experience with optical, mechanical, electrical, automation, and/or fluidics systems. Ability to learn and understand component level failures for unconventional or unique manufacturing systems. Working knowledge and understanding of statistics and DOE methodology using a reputable software such as JMP or Minitab. Knowledge of engineering analysis methodologies including Reliability Centered Maintenance (RCM), Failure Modes and Effects Analysis (FMEA), Root Cause Analysis (RCA), Fault‑Tree Analysis. Experienced in Process mapping using Business Process flow modelling (BPMN). Experience setting up performance driven maintenance service contracts. Advanced ability to read and understand engineering documentation (Wiring Diagrams, General Arrangements, SLDs, P&IDs…). Advanced Excel, Microsoft Office, Windows abilities. Document Control and Product Lifecycle Management (PLM) systems experience. Experience with CMS/MMS, preferably with SAP PM/MM. Demonstrated ability to work in a matrixed environment and to influence process change via interpersonal skills. Self‑motivated and proactive. Compensation The estimated base salary range for the Senior Reliability Engineer role based in the United States of America is: $98,400 - $147,600. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. Benefits Access to genomics sequencing. Family planning. Health/dental/vision. Retirement benefits. Paid time off. Equal Opportunity and Inclusive Environment We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero‑net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. Illumina is an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact View email address on click.appcast.io. To learn more, visit: The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship. #J-18808-Ljbffr Illumina