Senior Scientist or Scientist - Drug Metabolism and Pharmacokinetics (DMPK)

Position Summary The Senior Scientist or Scientist conducts laboratory-based studies under the general guidance of the Director. Independently designs and executes experiments to support drug discovery and development efforts within their area of expertise. Analyzes and interprets data, refines experimental approaches, and contributes to the communication and reporting of research findings. The laboratory-based role requires direct execution of bioanalytical, in vitro DMPK, and in vivo PK studies in a small-molecule drug discovery and development setting. Key Responsibilities Perform quantitative LC-MS/MS bioanalysis of small and/or large molecules in biological matrices (plasma, tissues, etc.) from in vitro and in vivo studies to support PK/PD, ADME, and efficacy evaluations. Execute in vitro DMPK assays, including plasma protein binding, microsomal stability incubations, hepatocyte metabolism studies, and permeability assessments in cell monolayers. Conduct in vivo PK studies: dosing by various standard routes, terminal and non-terminal blood sampling, and organ/tissue collection. Develop and/or prepare preclinical formulations by dissolving or suspending test agents for in vivo dosing. Analyze data, maintain accurate records (LIMS, lab notebooks, reports), and communicate results to the Director and project team in a fast-paced environment. Perform other related duties as assigned to meet departmental and institutional goals. Maintain regular and predictable attendance. Minimum Qualifications Demonstrated experience with LC-MS/MS bioanalysis for small molecules. Practical laboratory experience running in vitro DMPK/ADME assays (protein binding, microsomes, hepatocytes, monolayers). Direct hands‑on experience executing in vivo PK studies (dosing, sampling, tissue collection). Working knowledge of preclinical formulation techniques (solutions and suspensions). Strong attention to detail, organizational skills, and ability to plan and work independently while collaborating effectively. Minimum Education and Training Bachelor’s degree in Chemistry, Biology, Pharmacology, Pharmaceutical Sciences, or related discipline required. Scientist Minimum Experience Eight (8) years of relevant work experience required. Six (6) years of relevant experience required with a Master’s degree. Three (3) years of relevant experience required with a PhD. Senior Scientist Minimum Experience Ten (10) years of relevant work experience required. Eight (8) years of relevant experience required with a Master’s degree. Five (5) years of relevant experience required with a PhD. Salary Range Senior Scientist: $104,000.00 – $186,160.00 per year. Scientist: $86,320.00 – $154,960.00 per year. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This estimate is offered in good faith and a specific salary offer will consider factors such as skill sets, experience, training, licensure, certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range, and compensation decisions are dependent on the facts and circumstances of each case. Equal Opportunity Employer St. Jude is an Equal Opportunity Employer. #J-18808-Ljbffr St. Jude Children's Research Hospital, Inc.