Principal Scientist, Oligonucleotide Analytical Chemistry

Principal Scientist, Oligonucleotide Analytical Chemistry

Location: USA - Massachusetts - Cambridge

Posted Date: Apr 14 2026

Key Responsibilities

• Develop and deploy robust analytical methods to support in-house oligonucleotide synthesis, including novel chemistries and conjugates
• Use advanced LC/MS-MS capabilities to fully characterize novel synthetic oligonucleotides and related species in low-and high-throughput settings
• Help design and manage key data pipelines
• Collaborate internally and externally, representing Oligonucleotide Discovery Analytical Chemistry on project teams
• Support analytical investigations, including root cause analysis, in collaboration with cross-functional teams
• Participate in hiring, mentoring and training of junior team members, ensuring knowledge transfer and capability development

Basic Qualifications

• A BS degree with at least 8 years of relevant experience or an MS degree with at least 6 years of relevant experience in analytical chemistry or a related discipline (or equivalent)
• Two or more years of experience using high-resolution LC/MS(-MS) methodology in a biotechnology, pharmaceutical, or academic setting
• At least one year of experience utilizing modern mass spectrometry data analysis techniques, particularly as applied to biopolymers such as oligonucleotides, proteins, and/or glycans
• At least one year of experience in high-resolution LC/MS(-MS) method development and method troubleshooting

Preferred Qualifications

• A PhD in analytical chemistry or a related discipline with three or more years of experience
• Professional experience in the field of oligonucleotide therapeutics
• Experience with high-throughput LC/MS(-MS) data acquisition and analysis
• Experience with the LC/MS(-MS) analysis of small molecules and/or biologics
• Experience with non-LC/MS analysis and characterization methodology, such as NMR, X-ray crystallography, UV/Vis spectrophotometry, or circular dichroism
• Exposure to other aspects of drug discovery & development, including in vitro biology, bioanalysis, DMPK, delivery, etc.
• Excellent communication, presentation, and documentation skills
• Familiarity working in cross-functional matrix project team

Compensation and Benefits

If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $111,375 to $185,625.

Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

Equal Opportunity Employer

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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