Principal Scientist

Principal Scientist - US, Lenexa, Kansas (KS)- LBA Method Development Team

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

Are you a scientist with expertise in method development? Take the next step in your career by joining ICON where you’ll advance groundbreaking clinical therapies by leading global client programs.

We are excited to be seeking a new Principal Scientist at ICON in Lenexa, Kansas (KS). The Principal Scientist will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.

We are seeking candidates with robust method development and knowledge in science for new biological modalities.

What You Will Do

This Research Scientist is responsible for method development and validation testing using complex ligand-binding analytical methods. In addition, you will oversee transfer of LBA methods for large molecules for further bioanalytical testing.

Desired Experience (ligand binding experience required)

• Ligand binding assays
  • ELISA, ECLIA
  • PK, PD, and immunogenicity
  • Usage of relevant software (e.g. SoftMax Pro, Watson, or equivalent)
• Neutralizing antibody or Flow Cytometry experience is beneficial.

Method Development

• Designs and executes experiments for method development under supervision or independently depending on level
• Develops new scientific approaches to method development and communicates these to the global science team
• Depending on level the scientist may:
  • Mentor more junior scientists and advise operation on developed methods
  • Reviews and approves data of other scientists
  • Communicate with team members and management regarding project status, purpose, scheduling, problems, etc.
  • Communicate and/or participate in communication with clients regarding project status.

Scientific

• Maintain knowledge and skill in all techniques where you perform your work.
• Provide scientific input to management and BD about new technology investments and lines of service.
• Discusses scientific results with sponsors together with project manager
• Promotes ICON utilizing their scientific skills through scientific communication such as external publication of posters and journal articles.
• Perform R&D projects
• Training of technicians on technical aspects
• Mentor and train staff on scientific topics

Quality and Timely Work Execution

• Takes initiative in process development and SOP/WI writing
• Legible, logical and reproducible documentation of all experimentation
• Has a thorough understanding and complies with GLP and other appropriate regulations
• Develops rugged and economical assays
• Performs data review of other scientist’s work

Sample Analysis and Assay Validation

• Provides key assay input to the validation and bioanalysis team(s) to ensure successful execution
• Assay troubleshooting
• May perform and document maintenance, troubleshooting and repairs on advanced instrumentation with support of service engineers or other trained supervisory personnel.

Qualifications 

• Read, write and speak fluent English.
• BS in a scientific discipline required. Advanced degree (MS or PhD), preferred.
• 5 – 10 years of industry or academic laboratory experience supporting ligand-binding assays.
• Demonstrated method development experience within the clinical or pharmaceutical industry with a track record of managing scientific projects.
• Presenter/Publisher in Regulated relevant field, nice to have.

#LI-KM3

What ICON can offer you:
Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

Are you a current ICON Employee? Please click here to apply