Senior Director, Oncology Pharmacology
Scorpion Therapeutics
Brief Description Lead scientific team members on oncology assets from discovery through regulatory approval. Manage the oncology pharmacology team and serve as lead on one or more programs. Establish efficacy in relevant disease models, demonstrate differentiation vs. comparators, determine PK/PD/efficacy relationships, characterize mechanisms of action, and identify predictive models, indications, and biomarkers. Design and execute studies aligned to clinically relevant priorities; support R&D and regulatory submissions (IND through NDA/BLA sections). Design/execute (or oversee) experiments with CROs/in-house/academics; review clinical protocols; author/review technical and regulatory documentation; present research internally/externally. Collaborate in cross-functional matrix teams and represent ORP on internal nonclinical strategies for hematologic malignancies and solid tumors. Essential Functions Design/execute experiments to elucidate efficacy, tolerability, MoA, and biomarkers across multiple modality combinations. Critically evaluate biochemical/cellular assays; communicate across matrix teams; lead programs; mentor junior scientists. Outsource/manage CRO studies, protocols, timelines, and budgets. Required Skills/Qualifications Ph.D. (biology/biochemistry/immunology/pharmacology or related); substantial oncology and immuno-oncology experience. Deep preclinical oncology and Immuno-Oncology expertise (in vivo/in vitro models; immune cell biology; immunological endpoints). Experience across small molecules, biologics, ADCs, bi-specifics, T cell engagers, cell/gene therapies, RNA therapeutics. Strong understanding of nonclinical pharmacology/toxicology/DMPK/clinical pharmacology integration; cancer signaling pathways. Experience leading multiple complex programs (GLP/non-GLP), designing biomarker strategies, and authoring nonclinical IND/NDA/BLA components. People management and strong project management; proficiency with tools (e.g., GraphPad Prism). Benefits (US candidates) May be eligible for annual cash bonus/incentive and discretionary equity grants; medical/dental/vision, 401k, and flexible paid vacation. #J-18808-Ljbffr Scorpion Therapeutics
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