Sr Scientist, Biologics Characterization

Regeneron’s Product Biochemistry in Tarrytown, NY is seeking a motivated and innovative Senior Scientist to drive late-stage development (Phase II through commercialization) of biologics. You will develop and deploy analytical methods and purification strategies, enrich and characterize product variants, and help onboard new technologies that deepen product understanding and improve processes across the pipeline. This role is for you if you are scientifically creative, hardworking, efficient, flexible, and able to perform key responsibilities in a fast-paced, team environment. Key Responsibilities: Develop analytical methods and purification protocols to support extended characterization of therapeutic proteins and gene therapy vectors. Conduct biochemical/biophysical characterization to support development, regulatory submissions, and commercialization. Apply DOE, advanced statistics, and risk assessments to evaluate and optimize methods and processes. Author high-quality technical documents (protocols, reports, memos) and contribute to regulatory sections and publications. Ensure timely documentation of experiments following established SOPs and guidelines. Maintain instruments, troubleshoot issues, and improve lab/data workflows within your area of expertise. Adhere to procedures, guidance, and best practices to ensure lab safety. Proactively identify process improvement opportunities across Product Biochemistry and Regeneron and help drive implementation. A Typical Day in the Role Might Look Like: Design and execute experiments to enrich, purify, and characterize size/charge variants, complexes, and high-concentration formulations. Integrate learnings from internal data and external literature to make science-based study design recommendations. Documents experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of protocols, method development reports, regulatory submission sections, and peer-reviewed articles for publication. Lead or participate in technology initiatives and continuous improvement projects; may also mentor and guide junior analysts in a matrix-based environment. Maintain instruments, troubleshoot instrumental/experimental problems, and order/maintain supplies. This Role Might Be For You If: Possess strong lab skills in protein separation, purification, and tangential flow filtration (TFF). Possess skills in protein/product identification using mass spectrometry. Thrive in a fast-paced, team environment and can also work independently across multiple projects. Demonstrate initiative, calculated risk-taking, and a passion for innovation and continuous improvement. Communicate clearly, manage projects effectively, and solve complex problems with data-driven rigor. Mentor others and contribute to a safe, efficient, and inclusive lab environment. This role requires a BS/MS/Ph.D. in Biochemistry/Biophysics, or related field plus 8-10 yrs+ (BS/MS) or 0-2 yrs+ of proven experience (Ph.D.). Technical proficiency in automated FPLC and/or HPLC (SEC, IEX, affinity), electrophoresis (capillary or microchip, SDS-PAGE, western blots), spectroscopy and light scattering is recommended. A fundamental understanding of protein structure/function, mass spectrometry, and immunology/immunogenicity preferred. Preference will be given to candidates who have experience working in the biopharmaceutical industry. Excellent oral and written communication skills and evidence of teamwork are required. This role is fully onsite. The ideal candidate must have strong initiative to complete tasks, learn new technologies, and demonstrate a commitment to continuous learning. This role requires the ability to manage multiple priorities in a fast‑moving R&D environment, operate effectively both independently and within a collaborative team environment, and communicate clearly, transparently, and in a timely manner with key stakeholders. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter. Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location. As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications. For jobs in Canada: this posting is for an existing position. Salary Range (annually) $109,900.00 - $179,300.00 Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.