Senior Principal Statistician

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.Job Function: Data Analytics & Computational SciencesJob Sub Function: BiostatisticsJob Category:Scientific/TechnologyAll Job Posting Locations:Spring House, Pennsylvania, United States of AmericaJob Description:About Innovative Medicine:Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.Learn more at We are searching for the best talent for a Senior Principal Statistician in Spring House, PA.Remote work options may be considered on a case-by-case basis and if approved by the Company.Please note that this role is also available across multiple countries and may be posted under different requisition numbers to comply with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s):Canada - Requisition Number: R- United States - Requisition Number: R- Remember, whether you apply to one or all of these requisition numbers, your applications will be considered as a single submission.Purpose:We are seeking an outstanding Senior Principal Statistician to join our Discovery Oncology Statistics organization within Johnson & Johnson Innovative Medicine Research & Development. This scientific leadership role provides strategic statistical leadership across oncology drug discovery programs, representing statistics in key scientific and portfolio discussions and helping drive critical decisions from target identification through candidate selection and translational biomarker development.This is an exciting opportunity to influence the future of cancer drug discovery by applying innovative statistical methodologies, machine learning, data science, and quantitative decision-making to some of the most exciting scientific questions in oncology. The successful candidate will collaborate across multidisciplinary research teams and contribute to innovation that directly impacts the advancement of transformational medicines for patients.You will be responsible for:Lead statistical strategy for priority oncology programs and shape scientific and portfolio decisions through quantitative evidence.Apply and advance statistical modeling, AI/ML, biomarker analytics, and quantitative decision frameworks to accelerate drug discovery.Drive experimental design, modeling, and data analysis across translational, in vivo, combination, and high-dimensional studies.Forge partnerships across functions and external organizations to advance program objectives and quantitative decision-making.Develop analytics capabilities, AI-enabled workflows, statistical methods, and decision-support tools with data science partners.Champion reproducible research, data integrity, statistical standards, and methodological rigor.Lead publications, scientific presentations, and external collaborations that advance statistical methods and scientific practice.Qualifications / Requirements:Education:Minimum of a PhD in Statistics, Biostatistics, Applied Statistics, Bioinformatics, Data Science, or a related quantitative discipline with a minimum of 6 years of relevant experience in pharmaceutical, biotechnology, or healthcare research is required.Required: Recognized expertise in statistical methods, experimental design, and quantitative decision-making for drug discovery and translational research.Track record of influencing scientific and portfolio decisions through quantitative evidence.Experience applying modeling, simulation, predictive analytics, and high-dimensional data analysis.Ability to translate statistical concepts into actionable insights for scientific and business audiences.Scientific leadership of complex programs, shaping scientific strategy and decision-making across multidisciplinary teams.Proficiency in R and modern computational and AI-enabled workflows.Travel: Up to 10-15% domestic and international travel may be required.Preferred:Recognized expertise in oncology drug discovery, translational research, and biomarker-driven decision-making.Experience applying machine learning, artificial intelligence, and advanced analytical methods to biomedical and drug discovery datasets.Experience with genomic, transcriptomic, proteomic, imaging, spatial biology, or other multi-omics datasets.Previous people leadership, mentoring, scientific coaching, or matrix leadership experience.Experience leading external collaborations, academic partnerships, scientific consortia, or industry working groups, with a demonstrated record of external scientific impact.Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource.#LI-HybridRequired Skills: Preferred Skills:SummaryLocation: Spring House, Pennsylvania, United States of AmericaType: Full time