Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Enterprise AI and Transformation Architect

Full-time

Simulations Plus

Role Description

The Principal Enterprise AI and Transformation Architect is a hands-on senior individual contributor responsible for discovering transformation opportunities, designing end-to-end solutions, and directly building and implementing enterprise AI, automation, integration, and business system capabilities. This role combines strategic thinking with practical delivery and is equally comfortable facilitating executive discussions, redesigning business processes, configuring enterprise platforms, building AI agents and workflows, integrating systems, and moving solutions from concept through production.

The majority of the role is focused on hands-on design, configuration, development, implementation, testing, and optimization, with the remaining time focused on strategy, architecture, stakeholder engagement, and mentoring.

Job Responsibilities

  • Business Transformation and Solution Delivery
    • Partner directly with Intelligent Process Automation & AI Enablement Manager and stakeholders to translate prioritized transformation opportunities and future-state process designs into technical solution architectures, prototypes, and implementation plans.
    • Lead technical discovery and feasibility assessment for complex transformation initiatives, identifying solution options, dependencies, constraints, risks, and integration requirements.
    • Translate business and process requirements into technical designs, working prototypes, implementation plans, and production solutions.
    • Own the technical delivery of selected initiatives through architecture, prototyping, build, testing, deployment, and stabilization.
  • Hands-on AI and Automation Development
    • Design, configure, build, test, and deploy enterprise AI workflows, copilots, intelligent agents, and automation solutions using approved platforms.
    • Engineer and implement agent instructions, prompts, tools, knowledge connections, APIs, guardrails, escalation paths, evaluation and monitoring mechanisms.
    • Build reusable workflows, prompt libraries, agent patterns, connectors, templates, and components that accelerate future delivery.
    • Troubleshoot, tune, optimize, and support deployed solutions to improve reliability, usability, performance, and business value.
  • Enterprise Systems & Integration Delivery
    • Design and implement enterprise-system configurations, workflows, business rules, and data structures where required to deliver cross-functional transformation and AI solutions.
    • Design and build API-based and platform-based integrations between ERP, CRM, financial, project management, collaboration, operational, data, automation, and AI systems.
    • Solve complex technical problems involving authentication, APIs, data flows, integration logic, exception handling, automation, and AI.
    • Partner with the Lead Business Systems Architect to ensure solutions align with enterprise system architecture, configuration standards, integration patterns, security requirements, and change controls.
    • Transition ongoing ownership of enterprise-system configurations and integrations to the appropriate system owner following implementation and stabilization.
  • Solution Architecture and Technical Leadership
    • Design end-to-end solutions spanning business processes, enterprise systems, data, integrations, automation platforms, and AI services.
    • Develop and recommend solution architecture and platform decisions for complex transformation initiatives, balancing speed, scalability, security, compliance, maintainability, user experience, and total cost of ownership.
    • Create lightweight reference patterns, design artifacts, and implementation standards based on solutions proven through hands-on delivery.
    • Serve as the technical lead and escalation point for complex initiatives while remaining directly involved in prototyping and implementation.
  • Prototyping, Experimentation, and Productizing
    • Rapidly build proofs of concept and working prototypes to test feasibility, demonstrate value, and reduce delivery risk.
    • Convert successful prototypes into secure, supportable, production-ready solutions with appropriate testing, documentation, controls, and ownership.
    • Evaluate emerging AI, automation, integration, and enterprise platform capabilities through practical experimentation rather than theoretical assessment alone.
    • Recommend whether to build, buy, configure, integrate, or retire capabilities based on demonstrated business and technical fit.
  • Governance, Quality, and Responsible AI
    • Implement responsible AI, security, privacy, data-use, human-oversight, documentation, testing, release, and support requirements within delivered solutions.
    • Build evaluation and quality-assurance approaches for AI outputs, agent behavior, workflow reliability, and exception handling.
    • Partner with Legal, Information Security, IT, Quality, and business stakeholders to ensure solutions meet applicable regulatory and enterprise requirements.
    • Create practical standards and reusable controls that enable teams to move quickly without sacrificing governance or compliance.
  • Technical Enablement & Scaling
    • Partner with the Manager, Intelligent Process Automation & AI Enablement to prepare users, process owners, and support teams for new ways of working.
    • Create technical documentation and knowledge-transfer plans for delivered solutions.
    • Scale successful solutions across functions by developing and adapting reusable technical patterns, components, integrations, and implementation playbooks.
  • Executive Partnership and Team Enablement
    • Communicate solution options, tradeoffs, progress, risks, and outcomes clearly to executive, business, and technical audiences.
    • Act as a high-trust thought partner to the Executive Director, helping shape the transformation and AI portfolio while taking direct ownership of priority work.
    • Mentor managers, architects, analysts, and solution teams through pairing, design sessions, code or configuration reviews, and hands-on problem solving.
    • Influence across functions without direct authority and create alignment among business teams, IT, vendors, and implementation partners.
  • Other Duties as Assigned

Qualifications

  • 8+ years of experience spanning business transformation, enterprise systems, solution architecture, intelligent automation, systems integration, AI enablement, or consulting roles.
  • Demonstrated hands-on experience designing, configuring, building, integrating, testing, deploying, and supporting enterprise solutions.
  • Hands-on experience building AI-enabled workflows, copilots, intelligent agents, retrieval-augmented solutions, or generative AI applications.
  • Hands-on experience configuring and integrating enterprise business systems and low-code platforms, such as ERP, CRM, Microsoft Power Platform, Copilot Studio, Dynamics, Salesforce, Freshworks, or comparable technologies.
  • Hands-on experience designing, building, and troubleshooting API-based integrations, including REST APIs, authentication, data flows, integration patterns, connectors, and event-driven processes.
  • Ability to translate ambiguous business challenges into technical solutions, working prototypes, and production implementations.
  • Experience designing human + AI workflows, prompts, tools, guardrails, evaluation methods, exception handling, and operational support models.
  • Ability to move fluidly between executive strategy, workshop facilitation, architecture, configuration, development, testing, deployment, and support.
  • Portfolio or examples demonstrating personally delivered AI, automation, integration, or enterprise system solutions strongly preferred.
  • Excellent executive communication, facilitation, documentation, presentation, and stakeholder management skills.
  • Experience delivering cross-functional initiatives in regulated or enterprise environments.
  • Experience in life sciences, healthcare, GxP, SOX, or similarly regulated environments preferred.
  • Enterprise architecture, cloud, Microsoft, AI, automation, Lean, Six Sigma, or related certifications preferred.
  • Occasional travel required for meetings, trainings, and conferences.

Education

  • Bachelor's degree in information systems, computer science, engineering, operations, pharmaceutical sciences, or related field.
  • Master's degree in information systems, computer science, engineering, operations, pharmaceutical sciences, or related field preferred.
  • Advanced enterprise architecture, cloud, automation, or AI certifications a plus.

Benefits

  • Fully remote work.
  • Flexible schedules.
  • Generous vacation policy.
  • Affordable health coverage.
  • Annual bonus.
Vacancy posted 11 days ago
Similar jobs that could be interesting for youBased on the Principal Enterprise AI and Transformation Architect in Remote vacancy
  • Role Description As a Principal Architect, Enterprise AI, you will shape how Avalara adopts AI across the enterprise. You will turn new AI capabilities...  ...contributor role reporting to the VP of Enterprise AI Transformation. While you will influence teams across the organization... 
    Principal
    Transformation
    Full time
    Remote work

    Bitovi

    Remote
    a month ago
  • $165.3k - $235k

    Principal Architect - Enterprise Application Ready to turn bold ideas into real-world impact? At Genpact, we don’t just adapt to change, we lead it. AI and digital innovation are transforming the way businesses work, and we’re at the forefront of it. Genpact’s AI Gigafactory... 
    Principal
    Transformation
    Full time
    Work at office
    Remote work
    Shift work

    BrightClaim

    New York, NY
    3 days ago
  •  ...people at UiPath believe in the transformative power of automation to...  ...creating category-leading enterprise software that unleashes that...  ...lies in the convergence of AI, automation, agents, people...  ...and enterprise systems.As a Principal AI Architect - Healthcare, you will... 
    Principal
    Transformation
    Work at office
    Immediate start
    Remote work

    UiPath

    Florida
    2 days ago
  • PRI Technology is seeking a Principal AI & Knowledge Graph Architect to lead the transformation of engineering standards into intelligent digital assets. This senior...  ..., ontology design, graph technologies, and enterprise-scale digital transformation. You will define a... 
    Principal
    Transformation
    Remote job

    PRI Technology

    Livingston, NJ
    2 days ago
  • $190k - $210k

     ...LivePerson (NASDAQ: LPSN) is a leader in trusted enterprise conversational AI and digital transformation. The world's leading brands use our award-...  ...AI technology. We are looking for a Principal Engineer, AI Architect to design and implement the latest Generative... 
    Principal
    Transformation
    Permanent employment
    Temporary work
    Local area
    Remote work
    Flexible hours

    LivePerson

    New York, NY
    1 day ago
  •  ...Join to apply for the Principal AI Architect role at Blue Cross and Blue Shield of Kansas Blue...  ...responsible for defining and driving the enterprise AI architecture strategy. This...  ...system designs that support business transformation, operational efficiency, and improved... 
    Principal
    Transformation
    Full time
    Immediate start
    Remote work
    Relocation

    Blue Cross and Blue Shield of Kansas

    Topeka, KS
    5 days ago
  • Principal Architect - PBM Modernization & AI EngineeringThe Principal Architect - PBM Modernization & AI Engineering...  ...solutions that accelerate the transformation of the Pharmacy Benefit...  ...designing, building, and modernizing enterprise platforms utilizing modern technology... 
    Principal
    Transformation
    Full time
    Local area
    Work from home

    CIGNA

    Austin, TX
    4 days ago
  • $122.4k - $194k

     ...the role As an Consulting Principal for AI & GenAI Platforms , you will...  ...by leading client-facing AI transformation initiatives focused on...  ...clients, consulting leaders, architects, and delivery teams to design...  ...platform architectures for enterprise clients. Partner with client... 
    Principal
    Transformation
    Remote work

    Cognizant

    Albany, NY
    5 days ago
  •  ...The Principal Architect AI SME in Delivery leads architecture for large Azure programs that span...  ..., including significant work at enterprise scale. ~7+ years of experience in...  ...delivery for Azure-based modernization, transformation, AI , or platform programs at... 
    Principal
    Transformation
    Full time
    Temporary work
    Remote work
    Visa sponsorship
    Work visa

    3Cloud

    Remote
    17 days ago
  • $103k - $165.3k

     ...communities. ​We are seeking a Data Architect to be one of the architects shaping Donaldson's enterprise data future. We're building a...  ...to influence how data, AI, analytics, and modern cloud technologies...  ...and drive enterprise-wide transformation.You'll love the opportunity to... 
    Principal
    Transformation
    Full time
    Work experience placement
    H1b
    Remote work
    Relocation
    Relocation package

    Donaldson company

    Bloomington, MN
    2 days ago
  •  ...chemicals firm is seeking a Senior Manager for AI Architecture Innovation to define and drive the enterprise GenAI platform strategy. The role involves building...  .... The position is remote, allowing flexibility while impacting a crucial transformation. #J-18808-Ljbffr Hexion
    Transformation
    Remote work

    Hexion

    Brooklyn, NY
    2 days ago
  •  ...diverse as cybersecurity, healthcare, aviation, defense, and enterprise transformation. We're making a difference every day—working for a safer,...  ...assurance, cyber survivability, secure cloud architectures, and AI-enabled cyber defense. The department integrates resilience... 
    Transformation
    Work experience placement
    Internship
    Local area
    Remote work
    3 days per week

    Mitre

    McLean, VA
    2 days ago
  •  ...Principal, Enterprise AI Transformation Principal, Enterprise AI Transformation Location: West Coast - Remote About the role: Principals are hunters. Senior ones. This role exists to do what most sales teams can't: open executive relationships at the world'... 
    Principal
    Transformation
    Immediate start
    Remote work

    Unframe AI

    San Francisco, CA
    1 day ago
  •  ...Principal, Enterprise AI Transformation Principal, Enterprise AI Transformation Location: East Coast - Remote About the role: Principals are hunters. Senior ones. This role exists to do what most sales teams can't: open executive relationships at the world'... 
    Principal
    Transformation
    Immediate start
    Remote work

    Unframe AI

    Philadelphia, PA
    1 day ago
  • $106.08k - $176.82k

     ...ShiftFirst (Days)Overview:OverviewThe Principal Enterprise Architect provides strategic and technical...  ...and roadmaps that guide enterprise transformation. This role evaluates system interactions...  ...in technologies such as mobile, AI, data center, infrastructure, cloud... 
    Principal
    Transformation
    Full time
    Temporary work
    Remote work
    Shift work

    Sentara Healthcare

    Virginia Beach, VA
    1 day ago
  • $157.94k - $209.27k

     ...of entertainment technology. Xperi is transforming how enterprise technology, data, automation, and AI work together across the company.Our business...  ..., and future digital experiences.The Principal Enterprise Data & AI Information Architect will lead the design of that... 
    Principal
    Transformation
    Full time
    Work at office
    Work from home
    Flexible hours

    Xperi Corporation

    San Jose, CA
    1 day ago
  • Role Description The Principal Enterprise Delivery Manager is responsible for ushering Atlassian’...  ...adoption of cloud features, including AI. ~Understand how data moves, systems...  ...Strategy: Lead end-to-end cloud transformation engagements by evaluating customer environments... 
    Principal
    Transformation
    Full time
    Local area

    Atlassian

    Remote
    6 days ago
  •  ...As we continue to scale our global platform, the Principal Product Manager, Enterprise Data Products & AI will play a critical role in building the trusted...  ...executing one of the most ambitious supply chain transformations in sports retail, rebuilding the technology backbone... 
    Principal
    Transformation
    Full time
    Contract work

    Fanatics Commerce

    Remote
    25 days ago
  • $190.6k - $286k

     ...the growth solution for enterprises today. We unleash...  ...data, integration, and AI layers.• Connect architecture...  ...scales.• Design and architect AI-enabled enterprise...  ...: Model what Principal-level looks like — self...  ...TEKsystemsWe're partners in transformation. We help clients activate... 
    Principal
    Transformation
    Permanent employment
    Full time
    Temporary work
    Remote work
    Flexible hours

    TEKsystems

    Dallas, TX
    2 days ago
  •  ...Senior Principal Enterprise Architect Our world is transforming, and PTC is leading the way. Our software brings the physical and digital worlds together, enabling...  ...with industry trends in PLM, digital thread, AI-driven product development, and manufacturing technologies... 
    Principal
    Transformation
    Immediate start
    Remote work

    PTC

    United States
    14 hours ago
  • The Principal Data Engineer serves as a hands-on technical...  ...and implementing enterprise-scale data...  ...pipelines, integrations, and transformations to support analytics...  ...practices.Experience architecting and implementing cloud...  ...supporting analytics, AI, machine learning, and... 
    Principal
    Transformation
    Remote work
    Flexible hours

    Mayo Clinic

    Rochester, MN
    5 days ago
  •  ...Principal Architect Caylent is an AI-first cloud services company that helps organizations turn ambitious...  ...compliance, and customer experience transformation. At Caylent, our people always...  ...or comparable CCaaS platforms at enterprise scale ~ Strong, current Amazon Connect... 
    Principal
    Transformation
    Remote work

    Caylent

    United States
    1 day ago
  • $94.2k - $141.2k

     ...next steps. Our partner is looking for a Principal Enterprise-Wide Applications Analyst based in the...  ..., system enhancements, upgrades, and transformation initiatives. You will work with...  ...How Jobgether works: We use an AI-powered matching process to ensure your... 
    Principal
    Transformation
    Full time
    Remote work
    Flexible hours
    Shift work

    jobgether

    United States
    6 days ago
  • $155k - $210k

     ...Job Level: Manager/Principal Business Unit: Technology...  ...Position Summary   Enterprise Strategy &...  ...Architecture, this Enterprise Architect role focuses on Data Platform...  ..., self-service, and AI-driven use cases....  ...including ingestion, transformation, storage, serving, consumption... 
    Principal
    Transformation
    Work at office
    Remote work
    2 days per week
    1 day per week

    Pacific Gas And Electric Company

    Oakland, CA
    11 days ago
  •  ...founded by former Google Cloud leaders, architects, and engineers. We are seeking...  ...innovative companies, leveraging AI as the key driver of their transformation. Our clients will look to you as...  ...agentic systems. At Zencore, a Principal Architect is a key technical leader... 
    Principal
    Transformation
    Full time
    Remote work

    Zencore

    Remote
    7 days ago
  • $80k - $100k

    Architect - Enterprise Application - SAP N Ready to turn bold ideas into real-world impact? At Genpact, we don’t just adapt to change, we lead it. AI and digital innovation are transforming the way businesses work, and we’re at the forefront of it. Genpact’s AI Gigafactory... 
    Transformation
    Full time
    Remote work
    Shift work

    BrightClaim

    Atlanta, GA
    3 days ago
  • $148k - $185k

     ...ride! Role Overview CarGurus is building Enterprise Data Solutions (EDS), a new customer-...  ...assets and prototype them via automated transformations (primarily using DBT). Partner with Data...  ...business strategy. Experience leveraging Gen AI to optimize workflows, create tooling,... 
    Principal
    Transformation
    Flexible hours

    CarGurus

    Boston, MA
    2 days ago
  •  ...Step into the role of a Principal Architect at JPMorganChase and become a driving force behind...  ...leaders to shape the digital transformation of merchant acquiring capabilities...  ...and developer experience Apply enterprise-authorized AI capabilities within the work environment... 
    Principal
    Transformation
    Worldwide

    JPMorgan Chase & Co.

    Plano, TX
    3 days ago
  •  ...Job Title: Principal Architect Type: Contract-to-Hire Parsippany...  ...Own enterprise architecture strategy and modernization...  ...modernization and platform transformation initiatives. Design APIs...  ...Data teams. Evaluate AI technologies and establish... 
    Principal
    Transformation
    Contract work
    Remote work

    VDart

    United States
    3 days ago
  • $152k - $221k

     ...with accounts and engage with Architects, Vice President Engineering...  ...around public cloud and enterprise technology, and promote Google...  ...space. The Google Cloud Principal Architect role is a hybrid...  ...institutions accelerate their digital transformations, and we continue to make... 
    Principal
    Transformation
    Local area

    Google

    New York, NY
    22 hours ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Enterprise AI and Transformation Architect. Be the first to apply!