Registered Nurse (RN) - PRN

About the Role

We are seeking skilled, compassionate, and dependable Registered Nurses for PRN assignments at hospitals and healthcare facilities in Greenville, South Carolina.

We are recruiting qualified RNs across multiple clinical specialties. Candidates will be considered based on their nursing experience, demonstrated competencies, current credentials, and ability to meet the requirements of their assigned units.
Nursing Specialties We Are Hiring For

• RN - Neuro Stepdown/SDU: Provide neurological monitoring and intermediate-level care for patients requiring increased observation and nursing intervention.
• RN - Medical-Surgical (Med-Surg): Deliver nursing care to patients with medical conditions, postoperative needs, and varying levels of acuity.
• RN - Operating Room (OR): Provide perioperative nursing care and support safe surgical procedures.
• RN - PACU (Pediatric): Provide postoperative recovery care and monitoring for pediatric patients following anesthesia.
• RN - Progressive Care Unit (PCU): Care for patients requiring intermediate-level monitoring and nursing interventions.
• RN - Pediatric Intensive Care Unit (PICU): Provide specialized critical care for critically ill or injured infants, children, and adolescents.
• RN - Pre-Op: Perform preoperative assessments, prepare patients for procedures, and support surgical readiness.
• RN - Telemetry (Tele): Monitor cardiac rhythms, assess patients, and identify changes requiring clinical intervention.
• RN - OR General: Provide perioperative nursing support for general surgical procedures.
• RN - OR Circulator: Coordinate intraoperative patient safety, surgical documentation, and collaboration with the surgical team.
• RN - Intensive Care Unit (ICU): Deliver critical care to unstable and critically ill patients requiring advanced monitoring.
• RN - Emergency Department/Emergency Room (ED/ER): Provide emergency assessments, triage as assigned, stabilization, and urgent nursing interventions.
• RN - Behavioral Health Services (BHS): Provide psychiatric and behavioral health nursing care, therapeutic communication, and patient safety monitoring.

Responsibilities

Responsibilities vary by specialty and assigned facility and may include:

• Assessing patients and developing, implementing, and evaluating individualized nursing care plans.
• Monitoring vital signs, symptoms, laboratory findings, and changes in clinical condition.
• Administering medications and treatments according to provider orders and facility policies.
• Recognizing clinical deterioration and escalating concerns promptly.
• Performing nursing procedures within the RN scope of practice and demonstrated competency.
• Maintaining accurate patient records and electronic health documentation.
• Collaborating with physicians, nurses, and interdisciplinary healthcare teams.
• Educating patients and families regarding treatment, recovery, medications, and discharge instructions.
• Following infection prevention, medication safety, patient identification, and confidentiality standards.
• Participating in shift handoffs, care coordination, and transitions of care.
• Responding to emergencies and following applicable rapid response and escalation procedures.
• Maintaining a safe, respectful, and patient-centered care environment.

OR nurses may perform perioperative duties and surgical safety procedures. Pre-Op and PACU nurses support surgical preparation and recovery. ICU, PICU, PCU, SDU, and Telemetry nurses provide care appropriate to patient acuity and monitoring needs. ED/ER and BHS nurses follow their respective emergency and behavioral health protocols.

Schedule and Work Environment

This is a PRN position offering shifts based on facility staffing requirements, patient census, unit needs, and confirmed availability. Shifts may include days, evenings, nights, weekends, and holidays.

Candidates should be comfortable working in fast-paced clinical environments, managing changing patient needs, following facility-specific protocols, and collaborating with multidisciplinary teams.

PRN scheduling does not guarantee a specific number of hours or shifts. Nurses are expected to maintain reliable attendance, communicate availability, and fulfill accepted assignments.

Ideal Candidate

The ideal candidate is clinically competent, compassionate, adaptable, and committed to safe, high-quality patient care. They demonstrate sound clinical judgment, effective communication, accurate documentation, and the ability to respond appropriately to changing patient conditions.

Applicants should identify their relevant specialties, clinical experience, current certifications, and shift availability. All required credentials and specialty competencies must be verified before placement.

Requirements

Required Qualifications

• Current, active Registered Nurse (RN) license valid for practice in South Carolina, or other legally accepted authorization to practice in South Carolina.
• Nursing education that meets applicable licensure requirements.
• Relevant clinical experience and demonstrated competency for the assigned specialty.
• Current Basic Life Support (BLS) certification as required by the facility.
• Strong clinical assessment, critical-thinking, communication, and documentation skills.
• Knowledge of medication safety, infection prevention, patient confidentiality, and facility protocols.
• Ability to recognize clinical deterioration and respond appropriately.
• Willingness to complete required onboarding, competency assessments, background checks, and credential verification.
• Ability to meet the essential functions of the position, with reasonable accommodation where applicable.
• Reliable transportation to assigned facilities in Greenville, South Carolina.
• Reliable attendance and availability for accepted PRN shifts.

Specialty-Specific Qualifications

• Neuro Stepdown/SDU, PCU, and Telemetry: Relevant monitoring experience; ACLS certification when required.
• Medical-Surgical: Medical-surgical or acute care nursing experience.
• OR General and OR Circulator: Perioperative experience, sterile technique, and surgical safety knowledge.
• Pediatric PACU: Pediatric post-anesthesia recovery experience and PALS certification when required.
• PICU: Pediatric critical care experience and applicable pediatric life-support certifications.
• Pre-Op: Experience with preoperative assessment, patient preparation, and perioperative safety.
• ICU: Critical care nursing experience and ACLS certification when required.
• ED/ER: Emergency nursing experience and applicable emergency care certifications, as required by the facility.
• BHS: Behavioral health nursing experience and knowledge of therapeutic communication, de-escalation, and patient safety.

Preferred Qualifications

• Previous PRN, float pool, travel nursing, or multi-facility experience.
• Specialty certifications such as CCRN, CEN, CNOR, PCCN, or other relevant credentials, where applicable.
• Familiarity with electronic health records and clinical documentation systems.
• Strong teamwork, adaptability, and professional communication skills.
• Availability for additional shifts, including weekends and holidays.

Certification and experience requirements vary by specialty and facility. All applicable South Carolina licensure requirements, credentials, and unit-specific competencies must be verified before placement.

Benefits

Why Consider This PRN Opportunity?

• Flexible scheduling: PRN shifts based on facility needs and your availability.
• Specialty-focused assignments: Opportunities aligned with your clinical experience and competencies.
• Professional development: Maintain and expand your nursing experience across eligible specialties.
• Collaborative environment: Work alongside physicians, nurses, and multidisciplinary healthcare teams.
• Varied clinical experience: Potential assignments across acute care, critical care, perioperative, emergency, and behavioral health settings.
• Additional shifts: Opportunities may be available based on staffing requirements.
• Meaningful patient care: Contribute to patient safety, recovery, and quality outcomes.

Benefits, compensation, and additional opportunities depend on the employer, facility, and assignment. PRN positions may not include the same benefits as full-time positions.