Clinical Research Sub-Investigator

Employment: Full-time, Monday–Friday, on-site in Chicago, IL

Reports to: Principal Investigator / Medical Director

License: Active, unrestricted Illinois MD license

Experience: 2 years of clinical research preferred

Position Summary

Cedar Crosse Research Center is seeking a full-time, licensed physician to serve as a Clinical Research Sub-Investigator. Working under the direction, training, and oversight of our Principal Investigator, the Sub-Investigator will provide protocol-specific medical care and help conduct Phase I–IV clinical trials in accordance with study protocols, FDA regulations, ICH Good Clinical Practice (GCP), IRB requirements, sponsor expectations, and Cedar Crosse policies. This is an on-site role for an MD who values patient safety, precise documentation, teamwork, and the opportunity to build deeper clinical-research expertise.

Essential Duties and Responsibilities

• Train under and collaborate closely with the Principal Investigator (PI); perform only those trial-related activities for which the physician is qualified, trained, and formally delegated.

• Conduct protocol-required medical evaluations, including medical-history review, physical examinations, perform the informed consent process, eligibility assessments, review of laboratory/diagnostic results, identify, assess and document Adverse Events, assess concomitant medications, and clinical follow-up.

• Evaluate potential participants against protocol inclusion and exclusion criteria and provide timely medical input on eligibility, enrollment, continuation, discontinuation, and referrals.

• Provide trial-related medical care and make participant-safety decisions in coordination with the PI, including appropriate management of abnormal findings and intercurrent medical issues.

• Complete clear, accurate, contemporaneous, and attributable source documentation; review and sign medical records, eSource, case-report forms, and other study documents within required timelines.

• Review safety reports, laboratory alerts, ECGs, imaging, and other clinical data when assigned; ensure appropriate follow-up and escalation to the PI.

• Maintain current knowledge of each assigned protocol, Investigator's Brochure, investigational product, study manuals, safety information, and relevant amendments.

• Participate in site-initiation visits, investigator meetings, study training, monitoring visits, closeout visits, sponsor/CRO calls, audits, and regulatory inspections as requested.

• Work collaboratively with clinical research coordinators, recruitment, regulatory, laboratory, pharmacy, data, and administrative personnel to keep studies safe, compliant, and on schedule.

• Respond promptly to sponsor, CRO, monitor, IRB, and internal requests; assist with data queries, corrective and preventive actions, protocol-deviation review, and inspection readiness.

• Protect participant privacy and confidentiality and comply with HIPAA, organizational policies, and all applicable ethical and regulatory requirements.

• Maintain required credentials and training, including medical licensure, CV, GCP, protocol training, delegation records, financial disclosures, and conflict-of-interest documentation.

• Assist with feasibility review, recruitment planning, patient retention, and other physician-level operational needs as assigned by the PI or Medical Director.

• Provide appropriate coverage for assigned studies during scheduled work hours and promptly communicate absences or coverage needs.

• Perform other study-related physician duties consistent with qualifications, training, protocol requirements, and PI delegation.

Required Qualifications

• Doctor of Medicine (MD) degree from an accredited medical school.

• Current, active, and unrestricted license to practice medicine in Illinois; must remain in good standing throughout employment.

• Ability to obtain and maintain credentialing required by sponsors, CROs, IRBs, and applicable research partners.

• Sound clinical judgment and the ability to recognize, evaluate, document, and escalate participant-safety concerns.

• Strong written and verbal communication skills, attention to detail, professionalism, and reliability.

• Ability to work on site full time, Monday through Friday, and collaborate effectively in a multidisciplinary research environment.

• Comfort using electronic medical records and research systems such as CTMS, eSource, EDC, eRegulatory, and sponsor portals.

• Commitment to participant rights, safety, welfare, confidentiality, research integrity, and accurate data.

Preferred Qualifications

• Two (2) years of clinical research experience as an investigator, sub-investigator, research physician, or comparable clinical-trial role.

• Prior experience with Phase I–IV industry-sponsored trials and FDA-regulated research.

• Current ICH-GCP and Human Subjects Protection training.

• Experience in one or more of Cedar Crosse's research areas, including obesity/weight management, type 2 diabetes, hypertension, migraine, asthma, COPD, or other cardiometabolic conditions.

• BLS/ACLS certification, DEA registration, and board eligibility or board certification, as applicable to assigned studies.

Success in This Role

• Participants receive thoughtful, timely, protocol-compliant medical care.

• Safety events and clinically significant findings are recognized, documented, and escalated without delay.

• Source records and physician reviews are accurate, complete, and inspection-ready.

• The Sub-Investigator develops increasing independence and research expertise while remaining within PI delegation and oversight.

• Study teams experience responsive physician partnership, clear communication, and dependable coverage.

Work Environment and Physical Requirements

This position is primarily performed in an outpatient clinical research setting and involves frequent interaction with participants and study staff. The physician must be able to perform customary clinical examinations and protocol procedures within the scope of licensure and training; use a computer for extended periods; communicate clearly in person, by phone, and electronically; and move throughout the clinic as needed. Reasonable accommodations may be made for qualified individuals with disabilities.

About Cedar Crosse Research Center

Cedar Crosse Research Center is an independent clinical research site in Chicago with more than 30 years of experience conducting hundreds of clinical trials. Our long-tenured, multidisciplinary team is committed to participant-centered care, high-quality data, ethical research conduct, and dependable sponsor partnership.

Equal Employment Opportunity

Cedar Crosse Research Center is an equal opportunity employer. Employment decisions are based on qualifications, merit, and business needs, without unlawful discrimination or harassment. This job description summarizes the role's primary functions and is not intended to be an exhaustive list of every duty, responsibility, or qualification. Duties may change based on study assignments, regulatory requirements, and organizational needs.

How to Apply

Please submit a current CV and a brief statement of interest to Cedar Crosse Research Center. Qualified candidates should be prepared to provide documentation of medical licensure, education, training, and relevant clinical or research experience.