Senior Product Manager, Oncology

Remote | Bay Area, CA or Austin, TX - Must be located near a Natera laboratory with the ability to commute onsite a few times per month.

Senior Product Manager, Oncology

About the Role: The Senior Product Manager, Oncology leads product development and commercial scale for Signatera, Natera's market-leading tumor-informed minimal residual disease (MRD) assay. This role owns laboratory turnaround time, throughput, and process stability across core lab sites. You will drive the change control review (CCR) pipeline end-to-end from root-cause investigation through requirements authorship, core team leadership, and post-launch hypercare monitoring.

As the product lead for lab process performance, you will leverage operational and sequencing data, build capacity and financial models for equipment and automation investments, and serve as the subject matter expert to Software Engineering and Digital Product Management on instrument integration and LIMS requirements. This is an analytical, data-first, execution-heavy role for someone who bridges technical change control, product requirements, SQL queries, and lab floor operations.

Primary Responsibilities:

• Own and execute the product roadmap for future Signatera features and service components.
• Write clear requirements that balance clinical customer needs with lab throughput realities.
• Build data-backed business cases and financial models for equipment, automation, and operational improvements.
• Run the change control process end-to-end: root cause analysis, requirements, board review, hypercare, and close-out.
• Define quantitative product performance indicators, track operational datasets, and drive systematic process improvements across teams.
• Establish go/no-go criteria and hypercare metrics for new feature launches, maintaining ownership through exit criteria.
• Conduct VOC interviews, market research, and competitive intelligence to validate product features and fuel market growth.
• Partner with product marketing to define positioning, pricing, and technical launch collateral.
• Communicate vision, roadmap progress, and technical updates clearly to cross-functional stakeholders.

Qualifications:

• Bachelor’s degree in life sciences, physical sciences, statistics, or engineering. Master’s or PhD preferred.
• Minimum 5 years of professional experience, including 2-3 years in product management, commercialization, or strategic consulting within diagnostics, medical devices, or oncology.
• Experience with products delivered as laboratory services strongly preferred.
• Demonstrated experience driving data-driven process improvements using operational data and VOC to eliminate failure modes across the sample lifecycle.
• Hands-on experience with quality systems (CAPA, nonconformance, change control) in a CLIA/CAP lab environment preferred.
• Experience with SQL, Snowflake, Statistical Process Control (SPC), or continuous improvement frameworks (Lean, Six Sigma) preferred.

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

• Annual performance incentive bonus

• Long-term equity awards

• Comprehensive health benefits (medical, dental, vision)

• 401(k) with company match

• Generous paid time off and company holidays

• Additional wellness and work-life benefits

Compensation Range

$154,600—$190,300 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

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Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams
- FBI Cyber Crime resource page