Senior Scientist I - Mass Spectrometry/Protein Characterization

Senior Scientist, Mass Spectrometry/Protein Characterization Location: Boston hub in Cambridge, MA, USA. To strengthen our Protein Sciences team, we are seeking a Senior Scientist who will serve as the LC/MS subject matter expert. This laboratory‑based position requires a proven ability in the acquisition and interpretation of LC/MS data from both intact protein and peptide mapping workflows. Working in a multidisciplinary team you will apply your expertise to complement the biophysical and biochemical characterizations of recombinant proteins and communicate with stakeholders across the U.S. research organization. Key Responsibilities Apply advanced Mass Spectrometry expertise to drive the characterization of proteins across diverse classes (soluble and membrane). Collaborate with scientific teams to advance drug targets and provide analysis of complementary biophysical techniques, including SEC, SEC‑MALS, mass photometry, FidaNeo, NanoDSF, and additional methods as required. Mentor direct reports, guiding experimental design, execution, and professional development. Characterize recombinant proteins of different classes (cytosolic, secreted, membrane, refolded). Maintain and oversee LC/MS equipment, applying current LC/MS technologies to innovate and drive proteomic and lipidomic workflows where applicable. Manage workload and demands from multiple projects by communicating experimental results, advising on methods, troubleshooting, and executing experiments. Support the Protein Sciences team by exploring new technologies, contributing to annual budgets and strategies, and maintaining modern instrumentation in the laboratory. Minimum Qualifications Ph.D. in a related field and/or several years of industrial, laboratory‑based LC/MS experience (biochemistry, chemistry, molecular & cellular biology, or biophysics) with 6–12 years of experience, or a BS/MS with 12–18 years of experience. In‑depth knowledge of Waters Connect and Thermo Scientific Xcalibur software. Hands‑on experience and responsibility for Thermo Orbitrap and Waters instrumentation coupled to UPLC systems. Peptide mapping expertise and knowledge of post‑translational modifications. Use of data analysis software packages for sequence mapping and intact mass deconvolution (e.g., ProteinMetrics Byos, Biopharma Finder, Proteome Discoverer or similar). Knowledge of protein expression systems. Experience troubleshooting and maintaining LC/MS systems. Excellent organizational, communication, record‑keeping, and team‑working abilities. Desirable Experience Experience with mass spectrometry data analysis of peptides and NCEs. Experience with biophysical techniques within a multidisciplinary environment (e.g., analytical SEC, SEC‑MALS, mass photometry, FidaNeo, NanoDSF). Knowledge of the drug discovery pipeline, including translational and clinical pharmacology as it relates to mass spectrometry analysis. Experience managing or mentoring junior scientists. Salary This position’s reasonably anticipated base salary range is $117,600 to $154,400 per year. The actual salary offered will consider internal equity and may also vary depending on the candidate’s region, job‑related knowledge, skills and experience, among other factors. Equal Opportunity Employment UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable federal, state, or local law. UCB invites you to voluntarily self‑identify during the application process. Provision of self‑identification information is entirely voluntary and a decision to provide or not provide such information will not affect your application or employment. Any information you provide will be considered confidential and will be kept separate from your application and/or personnel file and will only be used in accordance with applicable laws, orders, and regulations. Reasonable Accommodation If you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, please contact: View email address on click.appcast.io for application to U.S. based roles. Please note that if your enquiry does not relate to adjustments, we will not be able to support you through this channel. #J-18808-Ljbffr UCB Inc.