Associate Scientist I, Analytical Development

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Associate Scientist I will join the Analytical Development. This role supports analytical testing for drug substance and drug product development. The individual will perform routine laboratory testing, assist with analytical method development and qualification activities, and support release and stability testing for GLP toxicology studies and cGMP clinical trial materials.

This position offers the opportunity to learn analytical techniques in a collaborative laboratory environment while supporting programs across multiple stages of drug development. The Associate Scientist I works under the guidance of senior scientists and Analytical Development management.

Responsibilities

• Follow cGMP guidelines, laboratory procedures, and applicable SOPs.
• Perform routine analytical testing to support batch release, stability studies, and development activities.
• Assist with analytical method development, qualification, and validation activities.
• Learn and perform analytical techniques including HPLC, GC, FTIR, UV/Vis, LC/MS, Karl Fischer, and other laboratory instrumentation.
• Prepare samples, reagents, and standards for laboratory testing.
• Accurately document experimental procedures and results in laboratory notebooks and electronic systems.
• Compile data, prepare certificates of analysis, and assist with stability reports.
• Analyze experimental data with guidance from senior team members.
• Calibrate, maintain, and perform basic troubleshooting of laboratory equipment.
• Collaborate with cross-functional teams to meet project timelines and deliverables.
• Maintain a clean, organized, and safe laboratory environment.

Requirements

• Bachelor's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related scientific discipline.
• 0-2 years of laboratory experience (industry, academic research, internships, or co-op experience considered).
• Basic understanding of analytical chemistry principles and laboratory techniques.
• Familiarity with analytical instrumentation through coursework or laboratory experience.
• Strong organizational skills and attention to detail.
• Excellent written and verbal communication skills.
• Ability to work effectively both independently and within a collaborative team environment.
• Comfortable managing multiple priorities in a fast-paced environment.

Preferred

• Experience working in a cGMP or regulated laboratory environment.
• Hands-on experience with chromatography or other analytical instrumentation.

Wisconsin pay range

$57,000—$68,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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