Senior Scientist, Analytical Development
Crispr Therapeutics AG
- # Senior Scientist, Analytical DevelopmentApplyremote type: Site Basedlocations: South Boston, MAtime type: Full timeposted on: Posted Yesterdayjob requisition id: R-100090**Job Description:****Company Overview**Founded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY (exagamglogene autotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependent beta thalassemia. CRISPR Therapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTaseTM editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics has established strategic collaborations with leading biopharmaceutical partners, including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California.**Job Summary**Reporting to the Director of Analytical Development, the Senior Scientist will be responsible for development, implementation, and qualification of cell-based assays (potency, immunogenicity, etc.). The candidate will lead cell-based analytical technology transfers from Analytical Development to collaborators within and outside CRISPR Therapeutics. They will also author sections of regulatory briefing packages or submissions related to technical role.**Responsibilities*** Lead a team responsible for the development, optimization, and technology transfer and qualification of cell-based assays for Drug Products and Drug Substances across the CRISPR portfolio, including potency assays for ex-vivo and in-vivo programs. Lead the team in qualifying and maintaining cell lines for various potency assays.* Expertise in flow cytometry-based assays required to support various cell-based testing. Lead team responsible for trending potency data and establishing specifications for lot release and stability studies.* Provide technical and operational oversight to contract labs supporting cell-based potency tests for multiple products across the portfolio.* Maintain awareness of applicable regulatory guidelines in area of expertise, including but not limited to guidelines from ICH, USP, EP, and JP.**Minimum Qualifications*** Ph.D. in Biology, Chemistry, Chemical Engineering or related discipline with 4 -8+ years of post-PhD relevant industry experience, or non-PhD with 12-15 years of relevant experience.* Proficient in mammalian cell culture, flow cytometry, droplet digital PCR, sanger sequencing, and amplicon next generation sequencing platforms.* Proficient in statistical analyses software, including JMP, GraphPAD, Qubas, Softmax, FlowJo, MACSQuantify.* Proficient in parallel line analysis for interpretation of potency data.* Expertise applied to both ex-vivo and in-vivo cell and gene therapy platforms.* Experience in leading assay lifecycle management for Cell and Gene Therapy products is strongly desired.**Preferred Qualifications*** Ability to mentor a team of scientists into increasing responsibility.* Experience with authoring regulatory submission documents.* Experience with leading analytical method transfer and supporting process technology transfer.* Awareness of regulatory guidelines in FDA and EMA guidance documents, CFR, ICH, USP, and Ph. Eur.* Proficient in risk assessments to support comparability assessments, process and method changes, and establish drug product critical quality attributes.* Ability to work in cross functional teams supporting product development and tech transfers.**Competencies*** Collaborative – Openness, One Team* Undaunted – Fearless, Can-do attitude* Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.* Entrepreneurial Spirit – Proactive. Ownership mindset.Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site. Senior Scientist, Analytical Development: Base pay range of $140,000 to $155,000+ bonus, equity and benefitsThe range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
- J-18808-Ljbffr Crispr Therapeutics AG
Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Senior Scientist, Analytical Development in Boston, MA vacancy
- Orna Therapeutics, Inc. seeks a Senior Principal Scientist to drive analytical characterization of circular RNA and lipid nanoparticle therapeutics, focusing... ...Science, Discovery, and CMC to advance method development and product characterization in a fast-paced environment...Senior
$126k - $181.5k
...Indigo Agriculture.Position Summary:We are seeking a highly motivated and experienced candidate for a role of Senior Scientist on the Analytical Development and Quality Control team. This candidate will lead method development, optimization, and qualification efforts...Senior- Serif Biomedicines is seeking a Senior Scientist to lead method development, optimization, and qualification for novel nucleic acid therapeutics and LNP... ...junior team members and contribute to fast-paced analytical initiatives within a collaborative ADQC group. You will...Senior
- Amgen's Cambridge, MA team seeks a Process Development Senior Scientist in Attribute Sciences to advance analytical methods monitoring CQAs and support process characterization for biologics. You will lead protein characterization and LC/MS studies, develop automation-...Senior
- Mariana Oncology, Inc. is seeking a Senior Scientist I in CMC Analytical Development in Massachusetts to lead analytical method development and transfer for radiopharmaceuticals. You will generate high-quality data, support regulatory activities, and collaborate across...Senior
- Aurion Biotech in Cambridge, MA, is seeking a Senior Scientist in Analytical Science & Technology to lead method transfers and validations at external... ...ensuring milestones are met in late-stage cell therapy development. The role demands hands-on QC experience and a strong...Senior
- Aurion Biotech, Inc. is seeking a Senior Scientist for Analytical Development in Cambridge, MA, to execute assays for cell therapy products. The role encompasses conducting independent experiments, collaborating with various teams, and authoring technical documents for...Senior
- Serif Biomedicines in Cambridge, MA seeks a Senior Scientist for Analytical Development and Quality Control. You will lead method development for nucleic acid cargo and LNP products, mentor junior staff, and support regulatory filings in a fast-paced biotech setting. We...Senior
- Serif Biomedicines in Cambridge, MA, is seeking a Senior Scientist for Analytical Development and Quality Control to lead method development for nucleic acid therapeutics and LNP delivery platforms. This role requires hands-on benchwork, scientific rigor, and mentorship...Senior
- Senior Scientist, CMC Analytical Development Join to apply for the Senior Scientist, CMC Analytical Development role at Mariana Oncology . Get AI-powered advice on this job and more exclusive features. Job Description We are seeking an experienced Senior Scientist, CMC...SeniorFull time
$155k - $170k
Senior Scientist, Analytical Development Location: Cambridge, MA Salary Range: $155,000 to $170,000 About the Position Aurion Biotech is seeking a highly motivated Senior Scientist, Analytical Development in Cambridge, MA. This position will serve as an integral part...SeniorWork at office$126k - $181.5k
...Indigo Agriculture. Position Summary: We are seeking a highly motivated and experienced candidate for a role of Senior Scientist on the Analytical Development and Quality Control team. This candidate will lead method development, optimization, and qualification efforts...Senior$150k - $180k
...learning, bioinformatics, data science, engineering, and drug development, our multidisciplinary team in Toronto and Cambridge, MA is... ...Opportunity This role based in Cambridge, MA is focused on the analytical characterization and formulation of oligonucleotides in...SeniorLocal areaFlexible hoursWeekend workDeep Genomics
Cambridge, MA3 days ago- ...novel AI and data-driven approach to materials discovery and development to accelerate the transition to a sustainable economy. FL97 was... ...Sana Biotechnology. Responsibilities Design and implement analytical methods for characterizing a range of chemical transformations...Senior
- Job title : Senior Analytical Chemist - Solid State Characterization Location: Cambridge, MA... ...join our analytical group as a Senior Scientist for Solid State Characterization. The... ...synthetic platform within Global CMC Development that is striving to become an industry...Senior
$137k - $215.27k
...submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Senior Scientist, Biologics Process Analytical Method Development is responsible for leading in-process analytical method development for biologics programs. In this...SeniorMinimum wageLocal area$120k - $160k
...the exacting needs of our clients. We provide process development, produce GMP viral vectors, and provide cell transduction... ...and you can be part of that team. Job Summary The QC Senior/Principal Scientist for Analytical Method Validation is a key role within our Quality...SeniorImmediate startVisa sponsorshipGenezenlabs
Lexington, MA4 days ago$154.4k - $242.55k
...employment application is true to the best of my knowledge.Job DescriptionJoin Takeda as a The Senior/Principal Scientist, Analytical Cell Line Engineering and Bioessay Development plays a key role in managing and performing scientific research, development, and testing of...SeniorMinimum wageTemporary workLocal areaShift work$89.6k - $166.4k
...SummaryLI#-OnsiteLocation: CambridgeInternal Title: Senior Scientist ISupport discovery and development projects through the design, development, and execution... ...end ADME assay workflows integrated with AI-enabled analytics.Develop methods to support small and large molecule...SeniorFull time$170k - $225k
Charles River Analytics, a GRVTY company, creates solutions and technology to tackle the world... ...computing. The resulting research and development help to continuously advance government... ...exciting opportunity for a passionate senior level researcher with experience in Human...SeniorWork experience placementCasual workRemote work3 days per week$170k - $220k
Charles River Analytics, a GRVTY company, creates solutions and technology to tackle the... ...computing. The resulting research and development help to continuously advance... ...offer a career-defining opportunity for a senior scientist with a deep passion and expertise in computer...SeniorWork experience placementCasual workWork at office$117k - $184.2k
...one of the world’s biggest investors in Research & Development.We are seeking a motivated Senior Scientist to join our Digital Insights team within the... ...substance development, drug product development and analytical development. Digital is the multiplier that will allow...SeniorFull timeFor contractorsLocal areaFlexible hours$159.75k - $255.6k
...skilled and innovative Machine Learning Scientists to join our AI team, focusing on AI... ...Robotics. As a key member of our research and development efforts, you will play a crucial role... ....Excellent problem-solving skills, analytical thinking, and the ability to work independently...SeniorWork experience placementWork at officeRemote work- ...SummaryWe are seeking a highly motivated Senior Scientist with expertise in LC-MS-based antibody... ...candidate will perform hands-on analytical research focused on antibody-drug conjugates... ...that support discovery and early development programs.Key ResponsibilitiesPerform analytical...Senior
$98.7k - $183.3k
...Description SummaryCambridge MAInternal: Senior Scientist I or II#LI-OnsiteThe Preclinical... ...assessment for optimal drug discovery, development and commercialization, with state-of-the... ...communication skills and ability to translate analytical concepts for diverse audience and...SeniorFull timeWork experience placement$145k - $161k
...biology and a clearly defined clinical development and regulatory path, and each expected... ...to treat disease.Position SummaryThe Senior Scientist / Senior Engineer, LNP Process Development... ...and/or CDMOsStrong proficiency in analytical characterization techniques (HPLC/UPLC...SeniorFull timeContract workTemporary work- ...RA Ventures, is pioneering the development of precision-targeted immunotherapies... ...an experienced Principal Scientist to help establish and advance our analytical and biophysical characterization... ...updates to multidisciplinary teams, senior leadership, and external...SeniorLocal area
Synolo Therapeutics
Cambridge, MA8 days ago - Novartis Group Companies in Cambridge is seeking a Senior Scientist I to support discovery projects through in-vitro ADME assays and develop... ...ADME experience in drug metabolism, and knowledge of analytical techniques. The position offers a competitive salary and comprehensive...Senior
$138.6k - $257.4k
...Research is seeking an accomplished Imaging Scientist to join the Image Analysis team in... ...expertise in digital pathology, spatial analytics, and AI-enabled biomarker... ...understanding of tissue-based biomarker development, oncology biology, and translational researchStrong...SeniorFull time- GC Therapeutics seeks a Scientist or Senior Scientist to advance iPSC-based cell line development from bench to production scale. You will engineer iPSC-derived products... ...development, and collaborative work with Analytical Development, QA, Manufacturing, and R&D to drive...Senior
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Scientist, Analytical Development. Be the first to apply!
Related searches
- materials scientist Boston, MA
- scientist assay development Boston, MA
- entry level research scientist Boston, MA
- health scientist Boston, MA
- quality control scientist Boston, MA
- bioanalytical scientist Boston, MA
- deep learning scientist Boston, MA
- application scientist Boston, MA
- scientist antibody discovery Boston, MA
- senior analytical scientist Boston, MA