Scientist, Complex In Vitro Systems (Lung Focus)

We are hiring a Scientist, Complex In Vitro Systems (Lung Focus) to support our client in developing, characterizing, and qualifying advanced complex in vitro models to support the mission of delivering safe and efficacious medicines. In this lab-based role, you will provide scientific and technical expertise to support the development and implementation of human lung complex in vitro models (CIVM), including lung organoids, air-liquid interface (ALI) cultures, and lung microphysiological systems for drug development. Responsibilities include culturing and characterizing state-of-the-art lung CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets, and maintaining rigorous, high-quality documentation. This is a 12-month contract based in South San Francisco, CA Responsibilities Development, qualification, and implementation of innovative in vitro lung model systems (e.g., airway and alveolar organoids, ALI cultures, lung-on-a-chip co-culture platforms) to support disease modeling and lung safety risk assessment. Designing and executing experiments to characterize lung models, including evaluation of cell viability, morphology, and barrier integrity and function, using techniques such as cytotoxicity assays, confocal and high-content imaging, transepithelial resistance/permeability assays, and transcriptomic and proteomic analyses. Collaborating closely with cross-functional teams to align on complex model building with therapeutic strategies and program needs. Analyzing, interpreting, and clearly communicating study results to collaborators and stakeholders, and contributing to internal and external scientific presentations as appropriate. Maintaining comprehensive electronic documentation in accordance with departmental Standard Operating Procedures (SOPs) and contributing to study reports, safety assessments, and final deliverables. Qualifications PhD in Bioengineering, Cell Biology, Molecular Biology, Toxicology (or related fields) with 0-5 years of experience post-PhD with hypothesis-driven research in industry or academia. Experience in culturing multiple lung cell types, including relevant lung primary cells and cell lines. Proven expertise in developing, qualifying, and applying airway or alveolar organoids, co-culture systems, and microphysiological or microfluidic platforms, to support drug discovery and translational research. Proficiency with quantitative and qualitative characterization techniques such as qRT-PCR, RNA-seq, proteomics, immunofluorescence and confocal microscopy, live-cell and time-lapse imaging, high-content imaging/screening, and analysis of data generated from these assays. Strong experimental design skills, with demonstrated ability in troubleshooting, method development, and protocol optimization for complex in vitro systems. A collaborative, team-oriented scientist who prioritizes shared objectives and communicates effectively across disciplines, with a strong work ethic grounded in scientific rigor, attention to detail, and a commitment to excellence. Preferred Qualifications: Experience lung biology and immunology is a strong plus. Advanced proficiency in MATLAB and/or Python for image processing, algorithm development, and large-scale data analysis. $92,456-$115,565 Why Choose R&D Partners? As an employee, you have access to a comprehensive benefits package including: Medical insurance – PPO, HMO & HSA 401k plan Employee Assistance Program Long-term disability Weekly payroll Online timecard approval R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies. R&D Partners is an equal-opportunity employer. #J-18808-Ljbffr R&D Partners