Scientist-oligonucleotide

Skill set – Oligonucleotide synthesis and downstream processing, Analytical HPLC/LCMS/UV-vis Hands‑on lab support and process development for the chemical synthesis and downstream processing of oligonucleotide‑based drug substance Synthesis of oligonucleotides up to 11 mmol scale Downstream processing of oligonucleotides including prep‑HPLC, Ultrafiltration, annealing, concentration and Lyophilization In‑process analytical testing including AX‑HPLC, IPRP‑HPLC, LCMS, UV‑vis Technical support for optimization of contract manufacturing processes Qualifications BS in Chemistry with 3+ years lab experience, preferably in an industrial setting. Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC‑MS etc.). Related hands‑on experience is preferred. Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus. Experience in record‑keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance. Good communication skills are a must for this position. The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines. #J-18808-Ljbffr Integrated Resources, Inc ( IRI )