Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Investigator, Gastroenterology

Kinetic Clinical Research

Job Description

Job Description

About Kinetic Clinical Research

Kinetic Clinical Research (“KCR”) is a fast-growing, multi-site clinical research organization built by physicians and operators who understand the realities of modern clinical practice. Following the consolidation of several successful Southern California research sites, KCR is expanding its gastroenterology research portfolio and is seeking an entry level or an experienced Gastroenterologist to serve as a Principal Investigator (PI) and long-term clinical partner.

The Opportunity

This role is ideal for a gastroenterologist who wants to:

  • Expand or transition into clinical research leadership
  • Work in a supportive, well-staffed research environment
  • Participate in a growing research platform with long-term upside
  • Potentially progress toward profit-sharing or equity participation based on contribution, performance, and mutual alignment

Role Overview

As a Principal Investigator, you will lead and oversee GI related clinical trials, working closely with KCR’s experienced operations, regulatory, and recruitment teams. You focus on medicine and oversight — we handle the infrastructure .

Key Responsibilities

  • Serve as Principal Investigator on gastroenterology clinical trials (e.g., IBD, NASH/MASH, IBS, GERD, motility, liver disease, or related indications)
  • Provide medical oversight and ensure subject safety and protocol compliance
  • Review and approve study protocols, informed consent documents, and safety reports
  • Supervise Sub-Investigators and collaborate with CRCs and site staff
  • Participate in Sponsor meetings, feasibility assessments, and monitoring visits
  • Support patient recruitment and retention through clinical engagement
  • Maintain compliance with FDA regulations, ICH-GCP, IRB requirements, and KCR SOPs

What We Offer

  • Turnkey research infrastructure (experienced CRCs, regulatory, recruitment, pharmacy, and QA support)
  • Access to active and upcoming GI studies with strong Sponsor relationships
  • Flexible scheduling (part-time or per-diem arrangements available)
  • Competitive per-study or hourly compensation
  • Administrative and operational support so you can focus on clinical work
  • A collegial, transparent leadership team that values physician input

Growth & Partnership Potential

KCR is building for the long term. For physicians who demonstrate strong leadership, study performance, and alignment with our mission, there is a clear pathway to expanded roles , including:

  • Lead Investigator status across multiple studies
  • Involvement in study selection and portfolio development
  • Profit-sharing  opportunities tied to site growth and performance

(This is not a promise or guarantee, but a genuine opportunity we actively pursue with the right partners.)

Qualifications

  • MD or DO with Board Certification or Eligibility in Gastroenterology
  • Active, unrestricted California medical license
  • Prior Principal Investigator or Sub-Investigator experience preferred (but not required)
  • GCP-trained or willing to complete GCP training
  • Interest in clinical research, innovation, and collaborative growth

Why Physicians Choose KCR

  • We respect your time and expertise
  • We invest in systems and staff — not shortcuts
  • We view investigators as partners, not vendors
  • We are building something scalable, reputable, and physician-led

Vacancy posted a month ago
Similar jobs that could be interesting for youBased on the Principal Investigator, Gastroenterology in Anaheim, CA vacancy
  •  ...creating long-term professional and financial opportunities for our investigators. We are expanding our dermatology research platform and...  ...or board-eligible Dermatologist to join KCR as a Principal Investigator (PI) . The Opportunity This role is ideal... 
    Principal
    Hourly pay
    Daily paid
    Part time
    Flexible hours

    Kinetic Clinical Research

    Anaheim, CA
    a month ago
  • $312k - $379k

     ...current license to practice medicine. Maintain current board certification, if applicable Assume responsibility as the Principal Investigator for the duration of clinical trials Strong working knowledge of regulatory requirements and GCP standards Possess... 
    Principal
    Full time

    Collaborative-Neuroscience-Research,-LL

    Los Alamitos, CA
    4 days ago
  • CenExel Clinical Research seeks a board-certified MD/DO PI to lead clinical trials across phases I-IV. Responsible for study design, conduct, and reporting while ensuring regulatory compliance and participant safety. Will collaborate with medical staff, regulators, and ...
    Principal

    CenExel

    Los Alamitos, CA
    2 days ago
  • $152.8k - $186.6k

    Architecture & Facilities Engineering (A&FE) is seeking a Principal Electrical Engineer to serve as the Resort's foremost technical...  ...highest-risk electrical designs and submittals.Direct root cause investigations and failure analyses for the most significant or novel... 
    Principal

    Disney Interactive

    Anaheim, CA
    1 day ago
  • $145.6k - $276.8k

     ...global market. Join us and help shape the future of aerospace and defense.Collins Aerospace is looking for an experienced Senior Principal Systems Engineer - Test Lead who is passionate about solving complex problems and wants to make a real impact on the Joint Precision... 
    Principal
    Temporary work
    Work experience placement
    For subcontractor
    Work at office
    Remote work
    Relocation package
    Flexible hours

    Raytheon

    Fullerton, CA
    5 days ago
  •  ...in annual sales. Role Overview Fashion Nova Logistics is seeking a detail-oriented and highly observant Loss Prevention Investigator to support loss prevention, security, and asset protection efforts within our fast-paced distribution center. In this role, you... 
    Worldwide
    Flexible hours
    Shift work
    Afternoon shift
    Early shift

    Fashion Nova

    Santa Fe Springs, CA
    2 days ago
  • $75k - $232k

     ...exciting opportunities and company perks await!Job Description:The Principal Quality Engineer for Supplier Operations is responsible for...  ....Support Microchip factories and business units in the investigation and resolution of supplier-related quality issues through root... 
    Principal
    Permanent employment
    Full time

    Microchip Technology

    Garden Grove, CA
    5 days ago
  • $145.6k - $276.8k

     ...the global market. Join us and help shape the future of aerospace and defense.This position is for an experienced, motivated Senior Principal Electrical or Computer engineering candidate to be involved in the testbench design, implementation, and verification of a wide... 
    Principal
    Temporary work
    Work experience placement
    Work at office
    Remote work
    Relocation
    Flexible hours

    Raytheon

    Fullerton, CA
    3 days ago
  • Requirements / Qualifications (POSTING ONLY OPEN TO CURRENT CESD EMPLOYEES ONLY)APPLICATION PROCEDURE:Applicants must complete the following components of the application procedure and submit alldocuments via the EdJoin website by Friday October 23 2026 at 2:30 p.m.-...
    Principal
    Full time
    Work at office
    Immediate start

    Centralia Elementary School District

    Buena Park, CA
    8 days ago
  •  ...infrastructure, and commercial and residential development. We work hard. We play hard. We have fun. JOIN CANNON as a STRUCTURAL PRINCIPAL ENGINEER in IRVINE. Irvine offers warm weather, beautiful scenery, and is a top bicycling city with miles of on-road bicycle... 
    Principal
    Remote work
    Relocation package

    Cannon

    Buena Park, CA
    1 day ago
  • $132.4k - $251.6k

     ...of the global market. Join us and help shape the future of aerospace and defense.Applied Signal Technology (AST) is seeking an Sr Principal Systems Engineer / ICT Lead who strives for excellence and has a passion to be part of a team that strengthens our nation and improves... 
    Principal
    Temporary work
    Work experience placement
    Work at office
    Remote work
    Flexible hours

    Raytheon

    Anaheim, CA
    3 days ago
  • CenExel Clinical Research is seeking a Physician Principal Investigator to lead clinical trials in a demanding, collaborative environment. The role requires holding an M.D./D.O. with board certification, 1-3 years of PI or sub-investigator experience, and DEA/licensure... 

    Collaborative-Neuroscience-Research,-LL

    Los Alamitos, CA
    2 days ago
  • Acara Solutions in Cypress, CA is seeking a Senior Principal Algorithm Software Systems Engineer to lead advanced defense algorithms, real-time tracking, and Kalman filtering initiatives. The role combines technical ownership with cross-functional program leadership in... 
    Principal

    Acara Solutions

    Cypress, CA
    3 days ago
  •  ...: Pro - Engineering Position Type: Direct Placement Duration: Direct Placement Shift: First Shift Details: Job Title: Sr Principal Test EngineerLocation: On-Site - Cypress, CAEmployment Type: Direct HireIndustry: Defense & AerospaceCompensation: $170k - $220kShift... 
    Principal
    Worldwide
    Shift work
    Day shift

    Acara Solutions

    Cypress, CA
    2 days ago
  • $118.3k - $224.9k

     ...shape the future of aerospace and defense. We are looking for Principal Systems Engineers in Algorithms to support the Joint...  ...in performing data analysis and problem solving (e.g. anomaly investigation)Proficient technical writing and oral communication • Experience... 
    Principal
    Temporary work
    Work experience placement
    Work at office
    Remote work
    Flexible hours

    Raytheon

    Fullerton, CA
    5 days ago
  •  ...Principal Mechanical Engineer Seeking a Principal Mechanical Engineer for a high growth electro-optical, infrared, sensor defense contractor in the Cypress, CA area. The Principal Mechanical Engineer would be responsible for leading the 3D CAD design, structural dynamics... 
    Principal
    For contractors

    Randstad

    Cypress, CA
    5 days ago
  • $24 - $29 per hour

     ...Vehicle) Referral Bonus Quarterly lunches Daily fresh fruit And a lot more! About The Position Position Summary The Fraud Investigator / Loss Mitigation Analyst is responsible for identifying, investigating, and resolving fraudulent activities and losses related... 
    Hourly pay
    Contract work
    Temporary work
    Work at office
    Flexible hours

    Veros Credit

    Santa Ana, CA
    4 days ago
  • Fashion Nova Logistics is seeking a detail-oriented Loss Prevention Investigator to support loss prevention, security, and asset protection in a fast-paced distribution center. You will identify, investigate, and help prevent theft, fraud, and policy violations while monitoring... 

    Fashion Nova

    Santa Fe Springs, CA
    4 days ago
  •  ...Job Description Job Description POSITION:                                  ASSISTANT  PRINCIPAL  ( AP )  JOB DESCRIPTION:  The assistant principal’s  primary responsibility is aide the principal in  the strategic development, implementation, and management of all... 
    Principal

    Vista Charter Public Schools

    Santa Ana, CA
    3 days ago
  • $118.3k - $224.9k

     ...demands of the global market. Join us and help shape the future of aerospace and defense.This position is for an experienced, motivated Principal Electrical or Computer engineering candidate to be involved in the testbench design, implementation, and verification of a wide... 
    Principal
    Temporary work
    Work experience placement
    Work at office
    Remote work
    Relocation
    Flexible hours

    Raytheon

    Fullerton, CA
    4 days ago
  • $20 - $26 per hour

    Surveillance InvestigatorEager to start your career in a growing industry? Get paid to learn the ropes of fraud investigation and real-world surveillance. Frasco offers fully paid investigator training to help you launch your career!Compensation:Hourly Rate: $20 - $26 per... 
    Hourly pay
    Weekly pay
    Flexible hours
    Night shift

    Frasco

    Cypress, CA
    1 day ago
  • $118.3k - $224.9k

     ...dedicated to developing the next generation precision landing products and provide crucial support to existing fielded systems.This is a Principal Electrical Engineering position located on-site in Fullerton, California. We are seeking an individual with background in hardware... 
    Principal
    Temporary work
    Work experience placement
    Work at office
    Remote work
    Flexible hours

    Raytheon

    Fullerton, CA
    1 day ago
  • $183.09k - $256.57k

     ...optical prescription and optical layout, (4) support fabrication, assembly, integration and test for 100% on-time delivery, (5) investigate, identify, and resolve engineering problems involved in the manufacturing of Coherent Aerospace and Defense products to provide a... 
    Principal
    Contract work

    Attalon, Inc.

    Tustin, CA
    9 days ago
  • $75k - $232k

     ...exciting opportunities and company perks await! Job Description: Microchip HRR has a key opening in our Garden Grove office for a Principal Engineer – Design. This key position is primarily responsible for leading the development of Power Electrical Converters and... 
    Principal
    Permanent employment
    Full time
    Work at office

    Microchip Technology Inc.

    Garden Grove, CA
    2 days ago
  • $118.3k - $224.9k

    Date Posted: 2026-08-04 Country: United States of America Location: US-CA-FULLERTON-675 ~ 1801 Hughes Dr ~ BLDG 675 Position Role Type: Onsite U.S. Citizen, U.S. Person, or Immigration Status Requirements: Active and transferable U.S. government issued security clearance...
    Principal
    Temporary work
    Work experience placement
    Work at office
    Remote work
    Worldwide
    Flexible hours

    Prattwhitney

    Fullerton, CA
    1 day ago
  • $153k - $190k

    Job Description Job Description Position Description : Are you a structural engineer eager to pivot into the exciting world of Construction Engineering to help contractors get their projects built? We are looking for creative Project Managers to leverage our core...
    Principal
    For contractors
    Work experience placement
    For subcontractor
    Work at office
    Flexible hours

    Degenkolb Engineers

    Anaheim, CA
    a month ago
  •  ...verify product performance and guarantee Datasheet. Support testing in lab for new designs and initial samples. Monitor and investigate yield issues arising at any stage in the manufacturing and testing process. Support reliability team in new product... 
    Principal

    DAS Technology Group

    Orange, CA
    3 days ago
  • $20 - $24 per hour

     ...Job Description Overview Company Overview: Advance Your Career in Insurance Claims with Allied Universal® Compliance and Investigation Services. Allied Universal® Compliance and Investigation Services is the premier destination for a career in insurance claim investigation... 
    Work experience placement
    Work at office
    Local area

    Allied Universal® Compliance and Investigations

    Anaheim, CA
    27 days ago
  • $153k - $188k

     ...staying on budget, adhering to tight schedules, or creating landmark structural systems. We’re hiring at the Associate / Associate Principal  level in our  LA and Orange locations . If you are interested in joining our team and do not see your desired position on our... 
    Principal
    Work at office
    Flexible hours

    Degenkolb Engineers

    Anaheim, CA
    8 days ago
  •  ...Pro - Engineering Position Type: Direct Placement Duration: Direct Placement Shift: First Shift Details: Job Title: Senior Principal Algorithm Software Systems EngineerLocation: Cypress, CA - HybridEmployment Type: Direct Hire or Contract to HireIndustry: Defense... 
    Principal
    Contract work
    Worldwide
    Shift work
    Day shift

    Acara Solutions

    Cypress, CA
    3 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Investigator, Gastroenterology. Be the first to apply!