Sr. Principal Engineer, Automation Engineering, Controls System Hardware - Lilly Medicine Foundry
$66k - $171.6kEli Lilly & Co
Job ID: R-100993Company: LillyLocation: Lebanon, Indiana, United States of AmericaJob Type: Full TimeCategory: EngineeringPosted Date: 2026-07-22At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. The Senior Principal Engineer - Automation Engineering will work as a member of the Automation Engineering Department at Eli Lilly, Foundry. The principal engineer will provide automation support for one or more operating areas across site and/or for capital projects, with primary focus on Instrumentation and Control Hardware. Process Automation is core to delivering the right first-time facility start up and continued support of ongoing manufacturing operations into the future.The Principal Engineer is also responsible for the productivity and mentorship of the other Engineers in the team with the purpose of ensuring that reliable and compliant control applications and systems are used in the manufacturing at Foundry. Additionally, the Principal Engineer, as a key technical expert will collaborate with partners within the process control organization and across functional disciplines to support the process control technical agenda, business plan priorities, and compliance objectives.In the project delivery phase and startup phase of the project (startup expected 2026 to 2028), automation engineering roles will be fluid and dynamic as we endeavor to support the project delivery, build a new organization, develop and implement the necessary systems and business processes required to support GMP operations, and build the site culture. This will require significant collaboration, creativity and resilience as the site grows to a full scale GMP manufacturing through start up. Key Objectives/Deliverables:Lead site operation support, capital project execution and commissioning & qualification.Demonstrated ability in translating technical concepts for executive audience and/or non-technical stakeholders.Deep Expertise working with DeltaV Distributed Control System, Batch Process Automation.Deep Expertise working with Rockwell Allen Bradley PLC’s, FactoryTalk View.Expertise working with DeltaV control panels, DeltaV Remote I/O panels and Rockwell I/O’s.Expertise in performing automation engineering activities including design, Development and Commissioning Process Automation projects using DeltaV DCS, tuning and troubleshooting of control loops.Thorough understanding of various process control communication protocols.Develop and implement the Automation Engineering Project Plan.Define strategies for periodic and corrective maintenance of Instruments and Control hardware.Operational ExcellenceSystem level thinking and expertise working with multi-disciplinary teams.Technical Leadership in leading projects from concept through Commissioning and Qualification.Demonstrated ability in resolving complex technical challenges with instrument and control system hardware.Technically lead and oversee the work of Site Area leads and System Integrators.Develop and Review Functional Requirements, Design Specifications and Test Specifications.Thorough understanding of 21CFR Part 11, GMP processes.Demonstrated experience with developing and utilizing Master maintenance plans.Lead/Participate in design reviews and Site system hardware reviews, attend equipment and FATs.Provide periodic status updates to Leadership and Project Management.Implement and support electronic systems (such as plant historians) used to capture process automation related production data.Maintain the validated state of the site control system hardware in line with Lilly quality standards including the development and execution of validation strategies and associated documentation.Promote the use of automation to improve productivity, operational efficiency and compliance.Develop a ‘network’ of corporate contacts and leverage corporate expertise when needed.Experience in clinical-stage manufacturing with flexible, multi-product capabilities is preferred.Organizational CapabilityIn coordination with automation and compliance consultants, set and reinforce standards for appropriate rigor in automation work products.Mentor process control team to strengthen technical capabilities and adopt best practices to enhance system reliability and business continuity.Be a fully active member of the flow leadership in running the plant, including participation on technical sub-teams.Basic Requirements:Minimum B.S. in Engineering or related field and experience in Automation Engineering8+ years working experience in Pharmaceutical or highly regulated environmentExperience working in highly automated facility, using DeltaV DCS, Rockwell Allen Bradley PLC, Veeva, PI, and/or BMS Warehouse Monitoring from design through Startup.Knowledge of GMP, regulatory requirements, computer system validationAvailable to participate in a rotational on-call scheduleQualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.Preferred Requirements:Demonstrated initiative, good planning and organizational skills, ability to prioritize tasks, commitment to task completion and timelines.Hands-on experience working directly with automation control panel hardware and wiring.Possess a keen technical curiosity and has demonstrated strong problem-solving skills and a desire for continuous improvementDemonstrated ability to influence peers and business partners, influence without authority.Good written and verbal communication skills for both technical and non-technical audiencesLilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (View email address on click.appcast.io), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$66,000 - $171,600Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLillySkillsdeltav distributed control systemrockwell allen bradley plcgmp complianceprocess automationbatch process automationfactorytalk viewdeltav control panelsdeltav remote i/o panelsrockwell i/o21cfr part 11veevapi systemsbms warehouse monitoringcomputer system validationcommissioning and qualificationproject managementmentorshiptechnical leadershipprocess control communication protocolsmaster maintenance plansdesign specification developmenttest specification developmentsystem integrationvalidation strategiesplant historian systemscontinuous improvementstakeholder management
$66k - $171.6k
...Date: 2026-08-07At Lilly, the work is... ...deliver life-changing medicines, strengthen how health... ...Lilly Medicine Foundry, a new center for... ...ResponsibilitiesThe Senior Principal Engineer - Automation Engineering will... ...and compliant control applications and systems are used in the...SeniorPermanent employmentFull timeWork experience placementH1bVisa sponsorshipWork visaFlexible hours$66k - $171.6k
...: 2026-08-13At Lilly, the work is demanding... ...life-changing medicines, strengthen how... ...Lilly Medicine Foundry:Lilly recently... ...Process Engineer to support the... ...engineering business systems. This role is... ...including automation recipes and procedures... ...of process control systemsCreativity...SuggestedPermanent employmentFull timeH1bVisa sponsorshipWork visaFlexible hours$66k - $171.6k
...026-07-29At Lilly, the work is... ...life-changing medicines, strengthen... ...Medicine Foundry:Lilly recently... ...experienced Process Engineers to support... ...:The Principal Process Engineer... ...business systems. In addition... ...Participate in automation recipe and... ...and control strategies for...SuggestedPermanent employmentFull timeH1bVisa sponsorshipWork visaFlexible hours$66k - $171.6k
...EngineeringPosted Date: 2026-08-13At Lilly, the work is... ...life-changing medicines, strengthen how health... ...:As an Automation Engineer you will provide automation... ...facility. Collaborate with system integrators to deliver... ...documentation. Automation/Control Discipline Partner...SeniorRelocationFlexible hours- Eli Lilly and Company is seeking a Senior Principal Engineer - Automation Engineering for the Lilly Medicines Foundry in Lebanon, Indiana. You will provide expert automation support across... ...DeltaV/Rockwell, LIMS, and LabVantage systems. The position requires 8+ years in...Senior
$123k - $180.4k
...2026-05-18At Lilly, we unite caring... ...life-changing medicines to those who... ...Lilly Medicine Foundry, a new center... ...Biologics Process Engineering provides... ...equipment and systems are used in the... ...deviations and change controls. Ensure GMP... ...computer, automation, and bioprocess...Permanent employmentFlexible hoursWeekend work- Lilly in Indianapolis, Indiana is seeking a Senior Principal Engineer - Automation Engineering to lead automated systems across the Lilly Medicine Foundry project, supporting GMP manufacturing startup from 2... ...You will mentor the process control team, shape design...Senior
$66k - $171.6k
...Date: 2026-07-29At Lilly, the work is... ...deliver life-changing medicines, strengthen how health... ...Lilly Medicine Foundry, a new center for... ...phase-appropriate control strategies, and ensures... ...the necessary systems and business processes... ...group and process engineering.Experience working...SeniorPermanent employmentFull timeH1bVisa sponsorshipWork visaFlexible hours$65.25k - $169.4k
...: 2026-08-11At Lilly, the work is demanding... ...life-changing medicines, strengthen how... ...Lilly Medicine Foundry — the first-... ...facility. The Principal Scientist, GMP... ...supporting the Sr. Advisor of Env... ...authors change controls and SOPs; and... ...limits, and water system testing; serve...Permanent employmentFull timeCasual workH1bWork at officeVisa sponsorshipWork visaFlexible hours$66k - $171.6k
...Date: 2026-07-29At Lilly, the work is... ...deliver life-changing medicines, strengthen how health... ...Lilly Medicine Foundry, a new center for... ...phase-appropriate control strategies, and ensures... ...the necessary systems and business processes... ...and agile engineers to join the PTE team...Permanent employmentFull timeH1bVisa sponsorshipWork visaFlexible hoursNight shift$65.25k - $169.4k
...2026-07-17At Lilly, the work is demanding... ...life-changing medicines, strengthen... ...Medicine Foundry, a new center... ...facility.The Principal Scientist - Deviation... ..., and change control for AGL at the... ..., and Engineering, this role authors... ...equipment, and systems.Perform hands-...Permanent employmentFull timeH1bVisa sponsorshipWork visaFlexible hoursShift workDay shift1 day per week$129k - $189.2k
...2026-04-24At Lilly, we unite caring... ...life-changing medicines to those who... ...Lilly Medicine Foundry, a new center... ...Foundry Process Engineering organization... ...Foundry's Quality systems. Serves as the... ...processes and control strategies for... ..., FUME/C&Q, Automation, Maintenance,...Permanent employmentTemporary workFlexible hours$151.5k - $222.2k
Overview At Lilly, we unite caring with discovery... ...and bring life-changing medicines to those who need them... ...the Lilly Medicine Foundry, our new, state-of-the... ...organization, and implement systems and processes for GMP... .../Biochemical Engineering Minimum of eight years...SeniorPermanent employmentFull time$65.25k - $169.4k
At Lilly, the work is demanding because patients are... ...deliver life-changing medicines, strengthen how health... ...create the Lilly Medicine Foundry — the first-ever... ...supports contamination control and production readiness... ...Data Integrity Across Systems: Review and approve EM...Permanent employmentFull timeCasual workH1bWork at officeVisa sponsorshipWork visaFlexible hoursShift work$129k - $189.2k
Overview The Lilly Medicine Foundry Process Engineering organization is responsible for chemistry... ...the Foundry's quality systems. Serve as technical... ...manufacturing processes and control strategies for drug substance... ..., Operations, FUME/C&Q, Automation, Maintenance, and...Permanent employmentFull timeTemporary workFlexible hours- Lilly is seeking a Senior Principal Engineer—Automation Engineering to join the Foundry. You will deliver automation support, lead process control activities, and mentor engineers while ensuring GMP compliance... ...across LAB and analytical systems. The role spans startup...Senior
- ...Description JOB DESCRIPTION Senior Automation Engineer Department: Automation FLSA... ...Building Automation and Manufacturing Control Systems. Maintain and grow the “Client for Life... ...network communication formats and hardware configurations ~ Understanding of basic...SeniorWork experience placementWork at officeImmediate start
- Lilly is seeking a Manufacturing Scientist/Engineer - Technical Operations for the Lilly Medicines Foundry in Lebanon, Indiana. The role supports and executes shift operations, ensures batch readiness, and collaborates with process engineers and R&D to transfer new processes...Permanent employmentShift work
- Lilly, headquartered in Indianapolis, IN, is building the Medicine Foundry to advance manufacturing and drug development. The Quality Assurance Associate, Manufacturing... ...and early phase activities, including change controls, investigations, and cross-functional collaboration...
- Lilly is seeking passionate chemists to join the PTE team at the Lilly Medicine Foundry in Lebanon, Indiana. The role focuses on translating API/conjugation processes to clinical supply readiness and overseeing technology transfer from development to pilot plant operations...Senior
- Lilly Technology Center in Indianapolis and the Lilly Medicine Foundry in Lebanon, Indiana, seeks a Scientist to lead the transfer of bioconjugation processes to early‑phase cGMP manufacturing. You will work across development labs and pilot plants to enable gram to kilogram...Senior
- Lilly in Indiana is seeking a Principal Scientist, GMP EM, to lead cleanroom environmental monitoring programs within the Medicine Foundry Analytical GMP Laboratory. You will oversee daily EM operations, guide technicians, and ensure compliance with cGMP, FDA, EMA requirements...Senior
- Lilly is seeking a Process Engineer to support the pilot plant in Lebanon, Indiana, focusing on kilo-lab and high-potency chemistry. You will solve... ...Parkwood West, with permanent operations at the Lilly Medicine Foundry. The role requires a B.S./M.S. in chemical engineering...Permanent employment
- Lilly is entering an exciting period of growth... ...delivering innovative medicines to patients around... ...highly integrated and automated manufacturing systems, and have a focus on... .... Performs change control, investigations, root... ...degree in IT, Engineering, Computer Science, or...Full timeContract workWork experience placementH1bLocal areaVisa sponsorshipWork visaMonday to FridayFlexible hours
- Lilly Medicine Foundry is seeking a Manufacturing Scientist/Engineer - Technical Operations to support and execute shift operations, ensuring batch readiness, and providing technical oversight to routine production. The role integrates with Process Engineering, PTE, and...Permanent employmentShift work
- Eli Lilly and Company in Indiana is seeking a Manufacturing Scientist/Engineer for the new Lilly Medicines Foundry. You will support on‑floor operations, drive changeovers, and collaborate with Process Engineering, PTE, and PRD to ensure safe, compliant production of medicines...Permanent employment
$123k - $180.4k
Initial Therapeutics, Inc. is seeking an Associate Director for Biologics Process Engineering to lead the team at the new Lilly Medicine Foundry in Lebanon, Indiana. This role includes overseeing engineering support for biologics manufacturing, ensuring compliance with...$129k - $209k
...technology transfer, implements control strategies, and ensures... .... The role is part of the Lilly Medicine Foundry construction and start‑up phase... ...single‑use bioprocessing systems. Mentor less experienced... ...cross‑functionally across engineers, analytical chemists, chemical...SeniorPermanent employmentFull timeFlexible hours- Lilly invites a Quality Assurance Associate, Manufacturing Operations to support GMP... ...IN, with a startup-facing role at the Medicine Foundry. The position emphasizes quality oversight... .... The role requires a BA/BS in Engineering or Science and at least 2 years of relevant...
- A global healthcare leader is seeking an experienced Advisor - Process Engineer to provide technical expertise and support for the Lilly Medicine Foundry in Lebanon, Indiana. Candidates should possess a PhD in Chemical Engineering or relevant field, with deep expertise...Senior
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