Senior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug Discovery
$167.4k - $310.8kF. Hoffmann-La Roche AG
Position Senior or Principal Machine Learning Scientist – Foundation Models team within Prescient Design (gRED), Roche’s AI for Drug Discovery (AIDD). Responsibilities Lead design and evolution of scientific reasoning systems; set technical direction for model architectures, training strategies, and evaluation methods. Define and execute approaches to improve model performance on scientific tasks, including long‑horizon reasoning and complex decision‑making. Translate biological and chemical domain knowledge into machine learning objectives, training signals and evaluation criteria, working closely with domain experts. Architect and improve large‑scale distributed machine learning systems, ensuring robustness, efficiency and reproducibility across training and evaluation workflows. Partner with researchers and cross‑functional teams to move models from research prototypes to production‑ready systems that support active discovery programs. Own end‑to‑end integrity of large‑scale training runs, from data orchestration to benchmark development. Mentor junior staff and interns, fostering engineering excellence and rapid experimentation. Define long‑term technical roadmap, identify new opportunities and set priorities across initiatives. Architect new initiatives that integrate diverse data modalities, guiding technical direction of cross‑functional projects across gRED. Serve as key technical authority for leadership, influencing how Genentech leverages generative AI to solve high‑stakes problems in the therapeutic pipeline. Qualifications PhD in Computer Science, Statistics, Mathematics, Physics or related quantitative field. For Senior (SE6): 0‑2+ years industry or post‑doc experience focusing on deep learning. For Principal (SE7): 5+ years industry or post‑PhD experience with demonstrated track record of technical leadership and project ownership. Extensive experience developing and training large‑scale ML models, including approaches to improve domain understanding, reasoning capabilities and model alignment. Strong publication record at top‑tier venues (e.g., NeurIPS, ICLR, ICML). Strong software engineering skills; experience designing and operating large‑scale or high‑performance ML systems. Preferred: experience with molecular modalities (protein sequences, chemical graphs, structured molecular data). Public portfolio of research or significant contributions to open‑source ML libraries. Passion for applying frontier AI to drug discovery. Benefits & Compensation Salary ranges vary by location and level: Senior: $167,400–310,800 in San Francisco; $160,100–297,300 in New York City. Principal: $194,000–360,400 in San Francisco; $185,600–344,600 in New York City. Payment includes base salary, discretionary annual bonus and benefits as described. Relocation Relocation benefits are NOT available for this posting. EEO Statement Genentech is an equal‑opportunity employer. We are committed to employing, promoting and treating all employees and applicants fairly based on merit, qualifications and competence. Our policies prohibit unlawful discrimination. #J-18808-Ljbffr F. Hoffmann-La Roche AG
- ...innovate. At Roche’s AI for Drug Discovery (AIDD) group, we... ...cutting-edge machine learning (ML) techniques.... ...Machine Learning Scientist to join the Foundation Models team within Prescient... ...to our internal reasoning large language... ...improve performance on scientific tasks, including...ScientificWork experience placementLocal areaRelocation package
$160.1k - $360.4k
F. Hoffmann-La Roche AG is seeking a Senior or Principal Machine Learning Scientist to join the Foundation Models team within Prescient Design, focusing on AI for Drug Discovery. Responsibilities include leading scientific reasoning system designs and improving model performance...SeniorScientific- F. Hoffmann-La Roche AG is seeking a Machine Learning Scientist for its AI for Drug Discovery group in New York. The role involves designing and implementing large... ..., or physics, with experience in machine learning model development and effective collaboration with...Scientific
$147.8k - $274.4k
Overview We are developing models to drive a step‑change in machine learning for drug discovery, transforming disparate processes into a unified approach across... ...in the consolidation initiative (for Principal Scientist). Senior Scientist Qualifications BS+7 to PhD+2 years...PrincipalSeniorRelocation package- A leading biotechnology company seeks a Machine Learning Scientist to join its AI for Drug Discovery team in New York City. This role focuses on designing... ...discovery through the use of large language models and advanced reasoning techniques. Candidates should have a strong...ScientificWork experience placement
$115k - $175k
Senior Scientist II, Applied Machine Learning and Agentic AI, Pharma R&D Tempus AI | Posted... ...automate the discovery of novel... ...and predictive models in oncology.... ...innovate on core scientific methodology... ...teams. Drug R&D Expertise... ...co‑scientist” reasoning. Multimodal...SeniorScientificFull timeShift work- ...JPMorgan Chase, AI and technology... ..., with the Machine Learning Center of Excellence... ...Learning Scientist - Natural Language... ...(NLP) - Senior Associate, you... ...machine learning models to solve real-... ...goals Scientific thinking with... ...We also make reasonable accommodations...SeniorScientificWork at office
$155k - $230k
...Medical Center Machine Learning Scientist Posted Oct 16 Full... ...good faith and reasonable estimate of the... ...on deep learning models for biomolecular systems and drug discovery. Projects span development... ...OpenFold, AISB (AI Structural... ...on specific scientific project) Design...ScientificFull timeTemporary workLocal area$111.2k - $185.4k
...Artificial Intelligence (AI) team at GE... ...mission. As a Senior Scientist, you will lead and... ...technologies, including machine learning, deep learning,... ..., and foundation models, to tackle... ...boundaries of human scientific understanding... ...and graph‑based reasoning, and (c) Integrating...SeniorScientificPermanent employmentFull timeWork experience placementWork at officeWork visaRelocation package$80 - $90 per hour
...knowledge in physics to a high-impact AI development project. In this role, you... ...next-generation AI systems, shaping how models learn, reason, and perform through high-quality, real... ...technologies, who excel at articulating complex scientific concepts in clear and concise ways....ScientificHourly payFor contractorsRemote work$141.1k - $262.1k
Genentech is seeking a ML Scientist to leverage AI and computational sciences for drug discovery in New York. This role involves designing foundation models, utilizing large datasets, and contributing... ...skills in Python and deep learning. Both industry experience and collaborative...Senior$40 per hour
...team and contribute to developing cutting-edge AI systems, while enjoying the flexibility of... ...to help advance AI development. AI models are increasingly capable of performing complex analytical and scientific reasoning — but these systems still need practitioners...ScientificHourly payFull timeRemote workFlexible hours$216k - $270k
SCALE LABS, RESEARCH SCIENTIST — AI CONTROLS AND... ...and safeguarding AI models and systems. Building... ...policymakers to make informed, scientific decisions about AI... ...research in machine learning, particularly in generative... ...with and providing reasonable accommodations to...ScientificFull time$40 per hour
...A technology company is seeking a Scientific Researcher (Physics) to train AI models by solving complex physics problems and evaluating their outputs. Candidates should have a strong understanding of classical mechanics and related physics concepts. The position offers...ScientificHourly payRemote workFlexible hours$229.9k - $262.4k
...Senior Manager, AI Engineering (People Leader... ...leader in using machine learning to create... ...customers. Our AI models and platforms... ..., research scientists, technical... ...intuitively understand scientific publications... ...promotes a drug‑free... ...provide needed reasonable accommodations...SeniorScientificFull timePart timeLocal area$141.1k - $262.2k
...seeking an experienced Senior Data Engineer to... ...working closely with machine learning, drug discovery, and cross‑company teams... ...of the TMR data model. Oversee cloud data... ...members. Collaborate with scientists and other engineers... ...search algorithms, scientific software development...SeniorScientificLocal areaRelocation package$229.9k - $262.4k
...Senior Lead AI Engineer (LLM Gateway, FM... ...leader in using machine learning to create... ...customers. Our AI models and platforms... ..., research scientists, technical... ...intuitively understand scientific publications... ...promotes a drug-free... ...provide needed reasonable accommodations...SeniorScientificFull timePart timeLocal area- ...candidate to advance its biological reasoning model, operating in a cutting-edge AI environment. This role... ...extensive industry experience in machine learning and representation learning.... ...record, and a passion for advancing scientific discovery. #J-18808-Ljbffr NamelyScientific
$229.9k - $262.4k
Senior Lead AI Engineer(MLX, Agentic AI,... ...leader in using machine learning to create... ...customers. Our AI models and platforms... ..., research scientists, technical... ...intuitively understand scientific publications... ...promotes a drug-free... ...provide needed reasonable accommodations...SeniorScientificFull timePart timeLocal area$229.9k - $262.4k
...Senior Lead AI Engineer (Gen AI Platform... ...leader in using machine learning to create... ...customers. Our AI models and platforms... ..., research scientists, technical... ...intuitively understand scientific publications... ...promotes a drug-free... ...provide needed reasonable accommodations...SeniorScientificFull timePart timeLocal area- At JPMorgan Chase, AI and technology promote our... ...journey, with the Machine Learning Center of Excellence (... ...As a Machine Learning Scientist - Natural Language Processing... ...-art machine learning models to solve real-world... ...with business goals Scientific thinking with the ability...SeniorScientificWork at office
- ...Expert to contribute high-quality insights on AI evaluation projects. The candidate will analyze large-scale scientific data sets and collaborate with interdisciplinary... ...to enhance AI capabilities in scientific reasoning. Applicants should have a PhD in physics or equivalent...Scientific
- A healthcare technology firm is seeking a Senior GenAI Scientist II to deliver innovative solutions that address payment... ...quality. This role requires expertise in AI and machine learning, with responsibilities including model validation, risk management, and improvements...SeniorRemote job
- ...seeking PhD-level chemists to enhance the safety of advanced AI models. The role involves writing expert prompts and evaluating... ...PhD in chemistry or a closely related field, possess strong scientific reasoning, and have sound judgments regarding chemical safety. The position...ScientificPart timeFlexible hours
$172.4k - $223.4k
Applied Scientist, AWS Applied AI Solutions Amazon Web Services (AWS) New York... ...extending existing scientific techniques and inventing new... ...Qualifications 3+ years of building models for business application... ...Experience building machine learning models or developing algorithms...ScientificFull timeWorldwideFlexible hours$166.98k - $220.66k
...Recursion’s early discovery team, you will... ...reimagining drug discovery from... ..., data scientists, platform and... ...statistical, and/or machine learning techniques) to... ...explain complex scientific concepts to a... ...OS, an AI-native, end-to... ...purpose-built AI models, and bilingual...SeniorScientificFull timeWork at officeLocal area- ...the next generation of AI: autonomous agentsâ¯that can reason, plan,â¯act,â¯and learnâ... ...Artificial Intelligence and Machine Learning team in Commercial and... ...AI andâ¯frontier models.⯠As an Applied AI ML... ...you will be a builder, a scientific pioneerâ¯and mentor who...Scientific
- Principal Clinical Scientist (AI Training) About The Role What if your hard... ...shape how AI reasons about medical evidence... ...Scientist to bring senior-level clinical and regulatory... ...— to ensure that AI models handling clinical... ...and a sharp eye for scientific quality....PrincipalScientificHourly payOngoing contractContract workFreelanceRemote workWorldwideFlexible hours
- ...investing in next-generation drug discovery and in-vitro... ...at the intersection of scientific execution, application... ...Experience with iPSC‑derived models or primary human cells... ...in applications scientist or field scientist roles... ...reports) Reports to Senior Vice President, New Business...SeniorScientific
- ...Intelligence team builds the machine learning and semantic... ...temporal and causal modeling, data valuation... ...assets. We are seeking a Senior Applied Scientist to lead and expand... ...optimizing downstream reasoning Establish rigorous... ...design, responsible AI practices, and scalable...SeniorWork at officeLocal areaRemote work
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