Application Scientist - LC-MS

Job Description

Job Description

Position Summary

Advion Inc. is seeking a full-time LC-MS Application Scientist to support application development, customer demonstrations, technical training, troubleshooting, and sales support for Advion's compact mass spectrometry product line, including the expression® CMS and the ASAP®, Plate Express™, and OPSI direct sampling platforms.

This role focuses on ESI- and APCI-based LC-MS applications, including method development, customer sample analysis, source optimization, data interpretation, and preparation of technical application materials. The ideal candidate will have hands-on LC-MS experience, strong HPLC/UHPLC method development skills, and the ability to communicate technical information clearly to customers and internal teams.

• Develop, optimize, and document LC-MS methods using ESI and APCI ionization on Advion compact mass spectrometers.
• Support applications for small molecules, APIs, impurities, reaction monitoring, natural products, environmental contaminants, food safety targets, and related compounds.
• Optimize LC-MS conditions, including ion mode, source parameters, mobile phase, additives, gradient, flow rate, and sample preparation.
• Develop and demonstrate workflows for direct ionization platforms such as ASAP®, Plate Express™, and OPSI where applicable.
• Generate high-quality chromatograms, mass spectra, extracted ion chromatograms, calibration data, and method summaries.
• Analyze customer samples and perform LC-MS demonstrations to support sales opportunities.
• Troubleshoot LC-MS issues related to chromatography, source performance, sensitivity, contamination, carryover, matrix effects, and reproducibility.
• Prepare application notes, demo reports, SOPs, training materials, posters, presentations, and customer-facing technical documents.
• Work closely with sales, service, R&D, product management, and marketing teams to support customers and identify new application opportunities.

• Bachelor's degree or higher in Chemistry, Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
• Hands-on experience with LC-MS using ESI and/or APCI.
• Hands-on experience in HPLC/UHPLC and LC-MS method development, including assay development, LC-MS-compatible mobile phase selection, and application to small molecules, peptides, proteins, or related analyte classes.
• Practical knowledge of source setup, tuning, optimization, and troubleshooting.
• Ability to interpret mass spectra, chromatograms, and method performance data.
• Strong technical writing and communication skills.
• Ability to work independently and manage multiple application projects.

This position is primarily laboratory- and office-based at Advion Inc.'s Ithaca, NY location. Travel of up to 25% (domestic and international) may be required for customer demonstrations, distributor training, trade shows, and field support.

Advion offers a competitive and employee-focused benefits package designed to support your health, financial well-being, and work-life balance. Employees enjoy generous paid time off, 9 paid holidays, flexible "X" days, a 401(k) plan with company matching, life and disability insurance, and access to an Employee Assistance Program. For 2026, medical coverage is provided through the Excellus BCBS Bronze 5 high-deductible plan, with Advion helping offset out-of-pocket costs by funding most of the deductible through a Health Reimbursement Arrangement (HRA). Employees also have access to dental, vision, flexible spending accounts, and family leave benefits

Advion Inc. is a developer of compact mass spectrometry and direct ionization technologies, serving chemistry, pharmaceutical, life science, environmental, food safety, and academic research laboratories. Advion's expression® compact mass spectrometer and direct sampling accessories - including ASAP®, Plate Express™, and OPSI - provide scientists with practical, efficient, and easy-to-use LC-MS workflows.