Senior Scientist
$115k - $145kFull-time
Repligen
Lead the design and optimization of next-generation affinity purification technologies for a wide range of biopharmaceutical modalities. This role combines high-throughput experimentation, data-driven process development, and cross-functional collaboration to deliver innovative purification solutions that accelerate bioprocessing performance and enable partner success. “This role is expected to model our Leadership Behaviors-Integrity & Compliance, Customer Focus, Collaboration, Courage, Team Empowerment, and Accountability & Results-in all aspects of work.” Key Responsibilities
- Design, develop, and optimize affinity chromatography-based purification processes for diverse biopharmaceutical modalities
- Execute high-throughput chromatographic screening and apply DOE methodologies to accelerate process development
- Analyze, interpret, and communicate complex datasets to drive decision-making and support partner adoption of new technologies
- Collaborate cross-functionally with internal teams (chemistry, analytics, commercial) to deliver integrated purification solutions
- Contribute to multiple development programs, ensuring timely execution and high-quality scientific output
- Innovate and propose novel approaches to improve purification performance, selectivity, and scalability
- Engage with external biopharma partners as a technical expert and scientific collaborator
- MS or PhD in Biochemistry, Chemical Engineering, Biochemical Engineering, or related field
- Minimum of 5 years of hands-on experience in downstream processing and protein purification; including FPLC
- Experience across multiple modalities (e.g., proteins, enzymes, vaccines, VLPs, gene therapy vectors)
- Expertise in chromatography method development, including automated/high-throughput systems
- Strong proficiency with Design of Experiments (DOE) for process optimization
- Working knowledge of analytical techniques (e.g., purity/impurity analysis, potency, stability assays)
- Broad scientific understanding spanning separations, protein chemistry, and bioprocessing
- Strong communication skills with the ability to translate data into clear, actionable insights
- Self-motivated, collaborative, and effective in a fast-paced, innovation-driven environment
Vacancy posted 25 days ago
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