Human Genetics Laboratory Leader

Job Description Summary We are seeking a highly motivated and experienced scientist to lead a Human Genetics laboratory. You will drive the translation of human genetic insights into actionable biological hypotheses to enable target discovery and validation across disease areas. The successful candidate will lead a small team of biologists and shape the genotype‑to‑phenotype translation strategy, integrating rare variant genetics, functional biology, and advanced analytical approaches to inform target prioritization. This position is part of the Human Genetics & Targets group within the Discovery Sciences (DSc) department in Biomedical Research at Novartis. The Human Genetics & Targets team is a global group of computational and experimental scientists dedicated to validating or invalidating genetics‑driven target hypotheses. The team's extensive expertise in genetics analytics, biology, and translatable models is enhanced by DSc's capabilities in AI, functional genomics, chemical biology, and more. The team collaborates with disease area specialists to identify disease associations, fully understand underlying disease mechanisms, and advance drug discovery projects to benefit patients in need. Position Details Internal Job Title: Senior Principal Scientist or Associate Director Location: Cambridge, MA (onsite) Key Responsibilities Lead and develop a high‑performing team of 2–3 wet‑lab scientists, establishing state‑of‑the‑art experimental capabilities to functionally characterize human genetic variation. Manage resources, priorities, and execution across multiple projects, ensuring high‑quality data generation, interpretation, and delivery aligned with strategic goals. Apply genetics expertise to enable recall‑by‑genotype strategies, including participant identification from biobank resources and design of deep phenotyping protocols. Serve as senior scientific leader to evolve the genotype‑to‑phenotype research strategy, translating rare variants into biological hypotheses and target investment decisions. Represent genetics expertise in cross‑functional teams and governance boards, contributing to portfolio prioritization alongside computational biology and disease area experts. Build and maintain strong internal and external partnerships, communicating scientific insights effectively to diverse audiences. Essential Requirements PhD with 8+ years of post‑graduate experience in genetics, with a focus on rare variants and/or genotype‑to‑phenotype translation. Strong background in experimental biology, including cellular models and gene perturbation technologies relevant to variant characterization. Extensive experience connecting clinical and/or biobank genetic data to biological mechanisms and therapeutic hypotheses across disease indications. Proven people leadership skills, including mentoring and developing scientists, with the ability to influence cross‑functional teams in a matrix environment. Curiosity for emerging technologies and methods, including AI‑based approaches for variant interpretation and prioritization. Exceptional collaboration, communication, and problem‑solving skills, with a strong track record of scientific innovation. Desirable Requirements Hands‑on experience in designing and executing recall‑by‑genotype studies. Target and/or drug discovery experience in an industry setting. Compensation & Benefits The salary for this position is expected to range between $138,600 and $257,400 USD annually for Senior Principal Scientist, and $152,600 and $283,400 USD annually for Associate Director. The final salary offered is determined based on relevant skills and experience, and will be reviewed periodically. Novartis may adjust the published salary range based on company and market factors. Your compensation will include a performance‑based cash incentive and, depending on the level of your role, eligibility to be considered for annual equity awards. US‑based eligible employees will receive a comprehensive benefits package that includes health, life, and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time‑off package including vacation, personal days, holidays, and other leaves. EEO Statement The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility & Reasonable Accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process or to perform the essential functions of a position, please e‑mail us at View email address on click.appcast.io or call View phone number on click.appcast.io and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $138,600.00 – $257,400.00 Skills Desired Analytical Thinking Chemical Biology Chemistry Clinical Research Clinical Trials Collaboration Curious Mindset Data Analysis Decision Making Detail‑Oriented Drug Development Ethics Machine Learning (ML) Medical Research Mentorship Patient Care Science Stakeholder Engagement Stakeholder Management #J-18808-Ljbffr Novartis Group Companies