Principal Scientist II - Pharmacology

Job Summary Band Level 4 Job Description Summary #LI-Onsite Location: Cambridge, MA. This position is located in Cambridge, MA and does not have the ability to be located remotely. Please only apply if this area is accessible to you. We are seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will lead the development and application of in vivo models for evaluating novel cancer therapies and advancing the early‑stage drug discovery pipeline. Responsibilities Design pre‑clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof‑of‑concept of new modalities. Develop in vivo CDX, PDX, and syngeneic models to evaluate anti‑tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions. Manage associate‑level scientists. Collaborate with cross‑functional project teams. Critically analyze and present results within a multidisciplinary team environment. Adhere to animal protocols and properly document data and methods in an electronic laboratory notebook. Qualifications PhD with 5‑8 years of research experience as a postdoc or in the pharmaceutical/biotech industry. Deep knowledge of antibody drug conjugates. Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models. Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry. Strong analytical, written and verbal communication, and organizational skills, including proficiency with PowerPoint and commonly used data analysis programs such as Prism and Excel. Compensation & Benefits The salary for this position is expected to range between $126,000 and $234,000 per year. The final salary offered is determined based on relevant skills and experience, and upon joining the company will be reviewed periodically. Your compensation will include a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time‑off package including vacation, personal days, holidays and other leaves. Equal Opportunity Employer Novartis Group of Companies is an Equal Opportunity Employer. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. #J-18808-Ljbffr U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.