Postdoc fellow - CRISPR screens in hematopoietic stem cells to study replication fitness
Perelman School of Medicine
University of Pennsylvania: Postdoctoral Positions: Perelman School of Medicine Postdoctoral Location University of Pennsylvania, Perelman School of Medicine Open Date Jul 31, 2026 Description A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Dr. Tong’s laboratory studies cytokine receptor signaling in replication stress , DNA repair , and ubiquitin signaling in hematopoietic stem cells , bone marrow failure , and leukemia . Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation, and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in blood development and the prevention of leukemia and ageing. This postdoctoral fellow position will focus on studying the mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function, which leads to bone marrow failure and/or leukemia. CRISPR screens with our expert collaborators will delineate a new understanding of stem cell fitness upon replication stress and point to potentially druggable pathways for intervention in the treatment of diseases with stem cell dysregulation. Recent Publications Cell Stem Cell 28(7):1275-1290, 2021 Journal of Clinical Investigation 136(1): e191713, 2026 Blood 138(22):2244-2255, 2021 Blood 133(14): 1560-1571, Apr 2019 Nature communications 9(1): 3915, Sep 2018 Genes & developm ent 31(10): 1007-1023, May 2017 You can find more of our recent publications and laboratory information in below website. Qualifications Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, and molecular biology, as well as mouse models. Highly motivated candidates with publication records are encouraged to apply. Questions Or Additional Follow Up Can Be Sent To Wei Tong, Ph.D - View email address on click.appcast.io Professor and Distinguished Chair in Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine (UPENN), Co-Director, Hematopoietic Stem Cell program, Institute for Regenerative Medicine at UPENN Philadelphia, PA, USA #J-18808-Ljbffr University of Pennsylvania Perelman School of Medicine
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