Senior Scientist I, Quantitative, Translational, and ADME Sciences (QTAS)

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at  . Follow @abbvie on  LinkedIn, Facebook ,  Instagram ,  X and  YouTube.

Job Description

The Biomarker team of Quantitative Translational ADME Science (QTAS) at AbbVie in Worcester, MA is seeking an experienced, creative, and highly motivated senior scientist to support bioanalytical method development, validation and preclinical/clinical sample testing for the discovery and development of novel therapies in multiple therapeutic areas. The Biomarker team focuses on PCR-based assays as well as ligand binding assays (LBA) to support exploratory and translational research that enables decision-making. The ideal candidate should have hands-on experience in a variety of technologies, including but not limited to qPCR, dPCR, ligand binding assays, high sensitivity and multiplex assays, sample processing and handling, etc. The candidate will be a key member of a global non-regulated bioanalysis team that support all AbbVie therapeutic areas.   

Responsibilities:

• Develop, qualify, and validate robust bioanalytical qPCR and dPCR workflows on a variety of sample matrices from a variety of species.
• Experienced  with various ligand binding assays on multiple analytical platforms across a variety of sample matrices.
• Conduct and document appropriately compliant biomarker sample testing to support pre-clinical and clinical studies.
• Plan and execute in vivo sample analysis based on bioanalytical protocol and study design.
• Interpret, present, and discuss assay results; use results to guide analysis and adjust strategy. Communicate experimental plans and results effectively, both verbally and in writing during regular lab meetings and with broader teams.
• Develop effective partnerships with discovery, preclinical safety, clinical pharmacology, and project team representatives in a highly collaborative and innovative environment to deliver high-impact quality data in a timely manner.
• Evaluate novel, pipeline-enabling, bioanalytical technologies to expand capabilities and enhance efficiency.
• Maintain timely laboratory notebooks (ELN) and LIMS records in compliance with AbbVie policies.
• Strong organization and communication skills, proactive , attention to detail, critical thinking, troubleshooting skills, independence, multitasking, desire to learn new techniques, and contribute to cutting-edge projects.

Qualifications

• Bachelor’s Degree or equivalent education with 10 or more years of relevant experience, Master’s Degree or equivalent education with 8 or more years of relevant experience, or PhD (molecular biology, biochemistry, or other related fields, preferred). 
• Extensive and proven experience in PCR-based bioanalytical workflows for pre-clinical and clinical projects, especially in DNA/RNA purification and qPCR, dPCR, etc.
• Proficiency with computers and data analysis/documentation software including platform specific tools, LIMS, and ELN
• Working knowledge of LBA (ELISA, MSD, etc.) biomarker bioanalytical assay development, validation, and sample testing workflows to comply with current regulatory standards and best industry practices.
• Excellent communication skills, and proven ability to work effectively as a member of a multidisciplinary team.
• Demonstrated capacity to work in a fast-paced environment with meticulous attention to detail, and an ability to handle multiple projects, prioritize work, and meet deadlines. 
• Working knowledge of handling clinical samples is a plus.
• Working knowledge of automation is a plus.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at  the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors  including  geographic location, and we may ultimately  pay more or less than the posted range. This range may be  modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to  participate in our short-term incentive programs.  ​

Note: No amount of pay is  considered to be wages or compensation until such amount is earned,  vested,  and determinable. The amount and availability of  any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a   particular employee  remains in the Company's sole and absolute discretion unless and until paid and may be  modified at the Company’s sole and absolute discretion,  consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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