Sr. Director, MASH/ALD Brand Lead & Pipeline

Sr. Director, MASH/ALD Brand Lead & Pipeline Location: Durham, NC Business Introduction GSK remains committed to achieving bold commercial ambitions for the future. By 2031, we aim to deliver £40 billion in annual sales, leveraging our existing strong performance momentum to significantly increase our positive impact on the health of billions of patients globally. Our Ahead Together strategy is centered on early intervention to prevent and alter the course of disease, thereby protecting people and supporting healthcare systems. Our diverse portfolio consists of vaccines, specialty medicines, and general medicines. Through continuous innovation and a dedicated focus on scientific and technical excellence, we strive to develop and launch new, groundbreaking treatments that address critical health challenges. Position Summary The role serves as the commercial Brand Lead for MASH/ALD assets and as the primary U.S. commercial authority for the broader Hepatology/Immunology pipeline and portfolio. The role has end-to-end accountability for pipeline strategy from early development through launch readiness and lifecycle management. The role owns and shapes the commercial strategy for MASH/ALD assets as they progress through development toward potential commercialization. It also owns the commercial vision and strategic framework that guide investment decisions, stage-gate recommendations, and commercialization planning for the broader Hepatology/Immunology portfolio, ensuring the U.S. customer and commercial perspective is authoritatively represented across governance forums and global decisions. The role also builds the commercial foundation for other pipeline assets before a dedicated brand team is in place, establishing positioning hypotheses, segmentation frameworks, and go-to-market approaches. For MASH/ALD specifically, this role serves as the commercial and strategic lead for the asset today and is expected to evolve into the full Brand Lead role as the asset advances through key milestones and, if approved, toward launch. The scope of leadership is expected to grow as commercialization planning, launch readiness, and cross-functional team leadership requirements increase. Key Responsibilities: Pipeline Strategy and Commercial Accountability

• Serve as the commercial and Brand Lead for MASH/ALD assets, owning and shaping the commercial strategy and leading cross-functional commercial planning and launch-readiness activities as the assets progress through development toward potential commercialization.
• Own U.S. pipeline and portfolio strategy for Hepatology/Immunology assets, establishing the commercial vision and prioritization logic that guide investment and launch-readiness decisions from Phase 2 through Local Operating Company (LOC) activation.
• Define and deliver, alongside the Medicines Commercialization Team (MCT) and Integrated Brand Commercialization Teams (IBCT), U.S. market analyses, competitive assessments, and commercial assumptions, informed by Medical-owned clinical development plans, health outcomes strategies, and financial valuations for Hepatology/Immunology pipeline assets.
• Serve as the single point of accountability for U.S. commercial input at early stage-gates, representing the voice of U.S. HCPs, patients, and payers in development decisions.
• Build and own the pre-launch commercial foundation for priority Hepatology/Immunology pipeline assets, including input to the target product profile (TPP), positioning hypotheses, customer segmentation frameworks, and initial value proposition development, ensuring each brand is commercially grounded well in advance of launch.
• Deliver stage-gate recommendations to global teams for Phase 2, 2b, and 3 decisions, clearly articulating the U.S. commercial opportunity, risk, and go/no-go rationale.
• Establish and evolve a long-range portfolio vision for Hepatology/Immunology, including asset prioritization, sequencing, and strategic planning to support future pipeline opportunities.

Portfolio Strategy, Insights, and Market Understanding

• Lead U.S. portfolio and lifecycle strategy across in-line and pipeline Hepatology/Immunology assets, ensuring consistency across brand strategy, commercial objectives, and Medical-owned strategy, and informing resource allocation and investment choices at the portfolio level.
• Develop market maps for the current and future Hepatology/Immunology portfolio, accounting for customer and patient needs, financial impacts, and the evolving healthcare landscape.
• Create and implement portfolio strategies in partnership with global counterparts, including U.S.-specific initiatives as needed, that account for multiple customer specialties, indications, and opportunities for indication expansion and lifecycle extension.
• Translate commercial and environmental assessments into forward-looking insights on how patient, marketplace, and customer needs may evolve, and ensure these perspectives are reflected in global strategy and brand-level planning.
• Leverage insights from in-line brand performance, customer experience, external experts, and competitive trends to inform portfolio strategy, indication prioritization, and lifecycle management across Hepatology and Immunology.
• Maintain an evolving perspective on reimbursement trends and market access dynamics to inform pipeline, commercial, and portfolio strategy.

Governance, U.S. Commercial Authority, and Business Partnership

• Develop and maintain deep expertise in the brand narrative, disease landscape, competitive dynamics, and customer segments for priority assets, ensuring continuity of strategic thinking from pipeline through launch and lifecycle management.
• Work alongside U.S. Health Outcomes, Medical Affairs, and Market Access to maintain a working command of the clinical, health outcomes, and economic evidence supporting brand value positioning and early payer strategy for Hepatology/Immunology medicines.
• Evaluate and recommend innovative go-to-market models for Hepatology/Immunology medicines, including differentiated approaches to customer engagement, channel strategy, and P&L optimization.
• Serve as the primary U.S. commercial authority at global governance forums, including the Forecast Review Committee (FRC), Portfolio Investment Board (PIB), and relevant stage-gate committees. Represent the U.S. commercial perspective with confidence and analytical rigor, with increasing accountability for MASH/ALD-specific commercial and launch-readiness decisions as the assets approach key milestones.
• Function as a delegated U.S. commercial decision-maker and strategic advisor to the Marketing VP for pipeline- and portfolio-related decisions, ensuring recommendations are grounded in U.S. market realities and are commercially sound.
• Build and maintain strong relationships with strategy and business unit leadership to ensure consistent U.S. input into global portfolio and pipeline decisions.
• Evaluate business development opportunities relevant to the U.S. Hepatology/Immunology portfolio and provide commercially grounded recommendations based on Business Unit strategy.

Financial and Operational Management

• Own the pipeline and portfolio strategy budget, including market research, competitive intelligence, and pipeline analytics as needed, with accountability for investment prioritization and efficient resource deployment consistent with business priorities.
• Collaborate with Forecasting & Finance to ensure an accurate outlook for U.S. Hepatology/Immunology launches, develop financial assumptions for pipeline assets, and identify additional value opportunities across the portfolio.

Leadership and Organizational Capability

• Provide strategic leadership across pipeline strategy and early commercialization, establishing clear direction, high standards, and effective ways of working across cross-functional teams.
• Set and maintain high standards for analytical rigor, commercial thinking, and stakeholder engagement, influencing partners to translate complex scientific and market data into commercially grounded recommendations.
• Contribute actively to succession planning, talent development, and organizational health across the Hepatology/Immunology commercial organization, while demonstrating the leadership capabilities required to take on broader responsibilities as pipeline assets progress.

Cross-Functional Leadership and Collaboration

• Collaborate with senior leaders across U.S. business units, Global Therapy Areas, Therapy Area Research Leaders, Medical Development Leads, Forecasting & Finance, Health Outcomes, and Business Development to establish portfolio and pipeline priorities and ensure the U.S. perspective is consistently represented in enterprise decisions.
• Lead cross-functional commercial planning for MASH/ALD and build and maintain strong relationships with Brand Leads, Medical Affairs, Market Access, and Commercial Leadership to ensure continuity of strategic thinking from pipeline through commercialization.
• Work seamlessly across key stakeholders in Sales, Insights & Analytics, Finance, Medical, and Global Product Strategy (GPS) to establish portfolio and pipeline priorities and ensure

Why you? Basic Qualifications

• Bachelor's degree is required (e.g., Marketing, Business, Life Sciences, or a related field).
• Minimum of 10 years of experience in pharmaceutical, biotech, or healthcare roles (e.g., brand marketing, new products or pipeline strategy, medical or clinical, market access, insights and analytics, or portfolio strategy), with Hepatology/Immunology experience in at least one of these functions.
• In-line brand marketing or brand management experience, ideally as a Brand Lead in specialty pharmaceutical or biotech, with direct accountability for developing brand strategy, positioning, customer segmentation, or launch planning for HCP-facing specialty assets.
• Experience with HCP- or patient-administered specialty medicines.
• Experience owning commercial strategy for pipeline and/or in-line assets.
• Experience leading cross-functional portfolio and/or pipeline initiatives.
• Experience leading strategic discussions with executive leadership, grounded in data-driven commercial insights.
• Experience managing budgets and investment priorities across a program or multi-asset portfolio.
• Direct people leadership experience, with a track record of developing talent and building high-performing teams.
• Must be willing to relocate to Durham, North Carolina

Preferred Qualifications

• Advanced degree strongly preferred (e.g., MBA, master's degree, or equivalent).
• Demonstrated Hepatology/Immunology marketplace experience, including a deep understanding of patients, customers, competitors, and business drivers across relevant specialties.
• Demonstrated leadership in portfolio, pipeline, or new product strategy, including experience leading assessments of go-to-market models and P&L optimization initiatives.

#LI-GSK How to apply If this role aligns with your experience and purpose, we would love to hear from you. Apply now and join us in making a meaningful difference for patients. Skills Data to Insights, Digital Fluency, Marketing Campaign Planning, Marketing Measurement, Marketing Strategy Implementation, Omnichannel Marketing, Scientific Literacy The US annual base salary for new hires in this position ranges from $204,750 to $341,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. Please visit [GSK US Benefits Summary]( to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - [View email address on us.fitly.work](mailto:View email address on us.fitly.work) GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at [