Senior/ Principal Scientist, Synthetic Molecule Analytical Chemistry

Overview We are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of laboratory innovation and technical depth to join our Synthetic Molecule Analytical Chemistry (SMAC) group. The successful candidate will thrive at the bench and solve complex analytical challenges, supporting programs from discovery through clinical development. Responsibilities Design, develop, and troubleshoot analytical methods from first principles, including sample preparation, method optimization, and data interpretation. Apply expertise in mass spectrometry, HRMS, MS/MS, and chromatographic separations to solve complex analytical problems during drug discovery and development. Contribute to regulatory submissions, authoring sections and preparing data packages for health authority interactions. Partner with cross‑functional teams (process development, formulation, safety science, quality, etc.) to develop control strategies aligned with cGMP, ICH, and regulatory expectations. Generate high‑quality data to guide molecular and formulation decisions and inform program decisions across discovery and early development. Innovate and evaluate new technologies in analytical chemistry or materials characterization to integrate state‑of‑the‑art instrumentation and software. Maintain a high‑level scientific profile internally and externally through pipeline contributions and scholarly achievements. Qualifications PhD in Analytical Chemistry, Pharmaceutical Sciences, Materials Sciences, Bioengineering, or related field with 0–2 years industry experience (Senior Scientist) or 3–5 years (Principal Scientist). Exceptional candidates with Bachelor or Master degrees and 12+ years of experience may be considered. Outstanding record of innovation and success in multiple projects during graduate, post‑doctoral, and industrial career with a sustained publication or patent record. Deep hands‑on expertise in at least one of the following areas for analysis of small molecules, peptides, oligonucleotides, polymers, or nanoparticles: mass spectrometry method development (HRMS, MS/MS, structural elucidation) or chromatographic method development (reversed phase, normal phase, HILIC, SEC, SFC, 2D‑LC/MS). Experience with chromatography or MS data systems such as Empower, Xcalibur, MassHunter, or Chromeleon and ability to independently analyze complex datasets. Excellent communication, organizational, leadership, and problem‑solving skills. Preferred: Knowledge of chemistry and formulation processes of nanoparticle‑based drug delivery systems, exposure to CMC, regulatory submissions, or analytical control strategies, and experience with AI‑assisted workflows. Familiarity with additional characterization tools (light scattering, rheology, spectroscopy, microscopy) is a plus. Benefits Salary: $124,300–$230,900 (Senior Scientist) or $143,200–$265,900 (Principal Scientist) based on location, experience, and qualifications. Discretionary annual bonus potential. Relocation benefits available. Qualified for standard Genentech benefits listed in the external benefits portal. Equal Opportunity Genentech is an equal‑opportunity employer. The company prohibits unlawful discrimination on the basis of protected veteran status, disability status, and other protected characteristics in accordance with applicable federal, state, and local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing the accommodations form. #J-18808-Ljbffr F. Hoffmann-La Roche AG