Neurodegenerative Disease Senior Scientist

Parallel Squared Technology Institute (PTI) is a non‑profit research institute developing technologies, reagents, and computational tools to increase the sensitivity and throughput of protein analysis, with a specific focus on single‑cell proteomics. We are applying these innovations to societally relevant areas of biomedical research, including studies of protein dysfunctions in Alzheimer’s and related neurodegenerative diseases. Summary of Position We are seeking scientist and senior scientist candidates to help drive our efforts to use single‑cell proteomics to understand the causes of Alzheimer’s and related neurodegenerative diseases. Ideal candidates will have expertise in the molecular mechanisms of neurodegeneration and hands‑on experience in single‑cell analysis, computational biology, and brain tissue handling. Candidates will work as part of an interdisciplinary team on NIH‑funded projects, using PTI’s proteomic technologies to discover new molecular mechanisms of neurodegeneration. Day‑to‑day responsibilities include designing and carrying out experiments to isolate and profile single cells from brain tissue, computationally analyzing large‑scale single‑cell proteomics datasets, preparing manuscripts and presentations, mentoring junior scientists, and meeting regularly with collaborators inside and outside of PTI. Candidates will initially work on ongoing projects but will have the opportunity to design and lead their own projects as well. Candidates with less than one year of postdoctoral experience will be considered for the scientist position; those with more than one year of experience will be considered for the senior scientist position. Responsibilities Design and execute research projects using single‑cell proteomics to understand the molecular mechanisms of neurodegeneration in Alzheimer’s and related diseases. Computationally analyze large‑scale single‑cell proteomic datasets to identify new molecular mechanisms of disease. Collaborate with external laboratories, brain banks, and tissue repositories on sample procurement. Prepare human brain tissue samples for proteomic analysis using methods and technologies developed at PTI. Help junior scientists gain expertise in experimental techniques used at PTI, analyzing and interpreting experimental results, recording data in laboratory notebooks, and writing up and presenting research results. Make regular presentations within PTI and to collaborators. Prepare manuscripts related to project outcomes and grant applications for external funding. Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others. Other duties as assigned. Qualifications PhD in Neuroscience or a related field. Direct, hands‑on experience in preparing human brain tissue for downstream analyses. Direct, hands‑on experience with single‑cell analysis. Excellent communication and interpersonal skills, record‑keeping ability, and attention to detail. Experience in high‑throughput or automated tissue sample collection, preparation, and analysis, particularly with human brains. Experience with mass spectrometry proteomics. Fluency in R or Python, particularly in the context of single‑cell analysis. Benefits Excellent medical, dental, and vision insurance with many $0 premium options for you and your family with several national and regional providers. Most employees have more than 20 plan options to choose from. Company‑paid group life, AD&D, long‑ and short‑term disability insurance. 15 days PTO + 10 sick days per year. 18 company holidays + your birthday off. $5,000 per year educational reimbursement. Up to 16 weeks paid parental leave. Equal Employment Opportunity Statement We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender‑identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind. #J-18808-Ljbffr Convergentresearch