Medical Director, Sickle Cell Disease, Clinical Development

Medical Director, Sickle Cell Disease, Clinical Development

Who we are:

At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture - one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion - because our differences shape how we hire, collaborate, and innovate. Our team's proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific - it's deeply personal, grounded in the meaningful connections we have built. To learn more, visit and follow Agios on LinkedIn and X.

The impact you will make:

Agios Pharmaceuticals is searching for a dynamic Medical Director to join our growing Clinical Development team. We want someone who cares about this important work, and who's driven to connect to our mission of helping these patient communities. The Medical Director will be responsible for the development and execution of clinical research and development programs for Agios including the leadership of the pivotal trials, pediatric trials, NDA and/or filing activities. This role will give strategic medical and tactical input to the Business Development team. This position will serve as a key liaison between company and clinical investigators and establish credible relationships with opinion leaders, and . This position will report to the Sr. Medical Director, Clinical Development.

What you will do:

• Direct involvement in trial design of Phase I/II/III targeting rare or orphan diseases; including pediatrics
• Provide on-going support for open-label extension periods and life cycle management of a product.
• Directly supervise and monitor trial conduct as well as work closely with external medical monitor physicians to assure consistency of conduct across trials. Work closely with all functions of the organization and external partners to manage trial execution.
• Provide medical input to global regulatory plans and regulatory meetings in partnership with regulatory affairs.
• Provide medical input to global safety leads and at safety meetings in partnership with safety and medical safety and risk management teams.
• Follow important developments and relevant trends in scientific literature and develop/maintain contracts with external experts to support understanding of the candidate drug effects and to gain strategic insights to the further development and placement of study and overall program.
• Develop effective relationships with clinical research organizations to ensure successful medical oversight of outsourced studies.
• Provide clinical assessments during disease/target evaluation, prioritization and selection, identifying novel therapeutics opportunities as well as critical study design and execution challenges.
• Support qualifications of pharmacodynamic/disease markers of assessment of efficacy.
• Work closely with the project management representative(s) to track trial status.
• Work closely with study physicians, as well as other project team members/functional areas to ensure regulatory compliance.
• Author and review clinical study reports, manuscripts, regulatory documents and other written material related to clinical study.
• Be responsible for the scientific quality of all clinical work.
• Ensure consistent practices with the highest ethical standards in compliance with internal SOPs, local regulations and laws.

What you bring:

• M.D. or equivalent degree
• Board Certification, Board Eligibility or specialist accreditation in internal medicine or pediatrics; specific experience with classical hematologic diseases is desirable.
• 3-10 years in industry (biotech/pharma) specifically within Clinical Development or closely related functions
• Clinical and managerial experience within pharmaceutical trial design and conduct (P within the pharmaceutical industry CRO or Academia is required. Experience with trials though NDA preferred, but not required
• Excellent interpersonal and public speaking skills are required for this high visibility position.
• Demonstrated ability to work in a matrix environment with cross-functional teams.
• Demonstrated leadership experience.
• Approximately 20% annual travel (domestic and international) is required for this position.

Concerned that you don't check off every box in the requirements listed above? Please apply anyway! At Agios, we value each other's differences and recognize that teams thrive when everyone brings their unique experiences to the table. We are dedicated to building an inclusive, diverse, equitable, and accessible environment where all employees can bring their whole selves to work. If you're excited about this role but your previous experience doesn't align perfectly with the job description, we still encourage you to apply. You may be just the right candidate for this role or another opening!

Work Location:

Location Agnostic: Work location for this role is based on employee's individual preference. This role has the ability to be either remote in the US or hybrid in our Cambridge Headquarters. Hybrid schedules vary but are generally less than 3 days per week onsite and hybrid employees are expected to live within commutable distance to our Cambridge Headquarters. Remote employees work entirely from home except for attending Company sponsored events/ meetings. For employees who choose to work remotely, travel may be required for certain company events commensurate to the above job description.

What we will give you:

• Deliberate Development. Your professional growth as one of our top priorities.
• Flexibility. We're all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you're at your best, we're at our best.
• Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team. For more detail on the benefits we offer at Agios, visit the Inside Agios section of our website.
• Competitive and equitable performance-based compensation. This includes base salary and both short- and long-term incentives that are connected to our business strategy and vary based on individual and company performance.
  • The current base salary range for this position is expected to be between $221,600 and $369,333 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators.
• Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries.
• Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We're continuously looking to improve the inclusivity of our workforce.
• Commitment to community. We're an active participant in the communities that surround us - the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

Interested in learning more about what makes our culture unique? Visit the Inside Agios section of our website.