Senior Scientist Research Computational Biology Platforms (ARIA)

Senior Scientist Research Computational Biology Platforms (ARIA) What you will do Lets do this. Lets change the world. The ARIA Computational Biology team is seeking a talented and creative computational biologist to further our mission of serving patients by advancing and replenishing the Amgen therapeutic pipeline. In this vital role, you will apply your expertise in data science and mechanistic disease biology to develop innovative methods and platforms that accelerate the identification, prioritization, and validation of transformative therapeutic targets within a dynamic, cross‑functional research environment. Focus areas include: Developing and applying methods and platforms to discover, prioritize, and validate targets across a broad range of diseases and therapeutic modalities. Designing and building a Precision Targeting Engine that integrates internal and high‑value public data into an automated, scalable framework with custom expression analytics across diverse data types and disease areas. Contributing to the design and evolution of Amgen's preclinical omics data ecosystem in partnership with the Research Informatics team. Evaluating and integrating emerging AI/ML technologies (e.g., biological foundation models), and developing custom research agents to accelerate early pipeline efforts. Partnering with data science and information systems teams to embed tools and analyses developed within ARIA Computational Biology into integrated R&D platforms. Training and mentoring other scientists in the use of advanced research tools and platforms. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications. Basic Qualifications PhD in computational biology, bioinformatics, data science, or a related discipline [and relevant post‑doc where applicable] Masters degree in computational biology, bioinformatics, data science, or a related discipline and 3 years of relevant research experience Bachelors degree in computational biology, bioinformatics, data science, or a related discipline and 5 years of relevant research experience Preferred Qualifications Strong programming expertise in Python and R, with proficiency in Linux/Unix environments, cloud computing, HPC, and collaborative development practices (e.g., Git). Experience developing complex computational tools and visualizations that translate biological insights into actionable strategies. Experience developing and deploying computational tools and pipelines, including use of workflow management systems (e.g., Nextflow), CI/CD practices, and interactive visualization tools (e.g., Shiny/Streamlit). Strong background in molecular and systems biology. Demonstrated expertise in the analysis and interpretation of single‑cell omics data. Experience leveraging and fine‑tuning transcriptional foundation models, large language models (LLMs), and biomedical knowledge graphs to advance research objectives. Familiarity with high‑value public data resources (e.g., DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe‑100M) used to complement and enhance analyses of internal datasets. Excellent communication and presentation skills, with the ability to convey complex concepts to diverse audiences. Self‑motivated, collaborative, and committed to continuous learning and growth. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we fully support your journey every step of the way. Salary and Benefits The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills, experience, and qualifications. A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan Stock‑based long‑term incentives Award‑winning time‑off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. #J-18808-Ljbffr