Senior Systems Engineer, NGS Platform & Lab Ops

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position Roche Sequencing Solutions at Santa Clara site is developing new technologies to make genetic testing easy, reliable, and affordable. We are creating technologies and workflows that can be used to improve the lives of people in a wide variety of applications including the timely screening of newborns for diseases and the diagnosis of cancers and infectious diseases. We are seeking a passionate Senior Systems Engineer to join our Systems Development Group to support the Next Generation Sequencing (NGS) products. The candidate is expected to be a hands‑on key contributor in the feasibility, development, customer support, and integration phases of end‑to‑end NGS solutions, according to customer & product requirements, and applicable regulatory and quality standards. This is a highly collaborative team and the Senior Systems Engineer will become an expert on the operation of the Roche Single Molecular Sequencing Platform. As a Senior System Engineer, you will learn how to use the new Roche Single Molecule Sequencing platform and help to develop the final operating protocols. The candidate will help design and perform wet‑lab experiments to further develop the sequencing prototype instrument. The candidate will work with his/her manager and team members to interpret the experimental results and design future experiments. The candidate must be self‑motivated and able to work well in a multidisciplinary team environment. The Opportunity You will perform a variety of sample prep, library, or sequencing and sequencing related experiments on a daily basis; you will help analyze and interpret the data. You will provide customer support activities such as monitoring runs, documenting and communicating defects, and following escalation paths to resolve customer issues; you will be expected to travel to customer sites if needed. You will perform all work using best laboratory practices and maintain a well‑organized and concise record of work performed and progress made. You will assist engineers with hardware design through testing subcomponents; you will collaborate to identify opportunities for continuous improvement. You will analyze data, derive conclusions, document findings, write SOPs and prepare reports for sharing within and between R&D groups. You will be expected to work independently with limited management direction to drive product development using strong experimental designs and to set up strong experimental designs while working independently. You will be expected to maintain detailed documentation throughout all phases of research and development. You will support our instruments; learn troubleshooting techniques as needed to assist R&D and to support customers. Who You Are You have a Bachelor’s in Science, Chemistry, Engineering or related field and a minimum of 2 years of related experience; or an advanced degree in the above related fields with 1 or more years of related experience. You have a strong understanding of DNA & Molecular Biology. You have proven hands‑on troubleshooting experience and skills in wet bench workflows on NGS platform. You have demonstrated experience working with multidisciplinary teams, i.e. chemistry, hardware, software. You have 3+ years of hands‑on experience with DNA sequencing such as raw sample preparation, nucleic acid extraction, library preparation, and NGS sequencing. You have previous laboratory experience with nucleic acid handling and contamination control. You have experience with statistical tools (Python/JMP for regression analysis, ANOVA), Design of Experiments methodology, and the application of statistical process control. You have proven hands‑on experience with PCR technology. You have demonstrated the ability to work well in teams and across scientific disciplines is essential. Preferred You have experience in implementing workflow on semiconductor‑based sensing devices or microfluidic devices. You have experience with prototype instruments or DNA sequencing. You have knowledge in surface chemistry. You have knowledge in all phases of NGS workflow such as nucleic acid chemistry, and primer design technologies for gene targets. The candidate should be passionate, self‑motivated, and possess a strong desire to acquire on‑the‑job training. This position is based onsite in Santa Clara, CA. This is not a hybrid position. Relocation benefits are not available for this job position. The expected salary range for this position based on the primary location Santa Clara, CA is $83,900 - $155,700. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. Benefits (

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Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life‑changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Equal Opportunity Employer Statement Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants ( #J-18808-Ljbffr Roche