Sr. Scientist, Gene Therapy and Gene Editing

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease. AskBio’s gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.Our vision: Pioneering science to create transformative molecular medicines.Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.Our principles:Advance innovative science by pushing boundaries.Bring transformative therapeutics to patients in need.Provide an environment for employees to reach their fullest potential.Our values:Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.Position SummaryThe Sr . Scientist , Gene Therapy and Gene Editing , will serve as a project leader for critical gene therapy and gene editing research initiatives, guiding scientific direction and experimental strategies. This role requires expertise in recombinant AAV biology, gene therapy and gene editing technologies, and drug discovery, with the ability to manage several independent projects covering a broad spectrum of R&D objectives. The Senior Scientist operates as a subject matter expert and is expected to develop innovative approaches for gene therapy/editing, validating and implementing techniques to advance R&D programs.This position is based in RTP (North Carolina) and reports to the Director, Cell Biology.Job ResponsibilitiesLead a team of scientists and research associates to design, plan, and execute to advance preclinical gene therapy programsProvide scientific leadership and project oversight across multiple gene therapy/editing projects, ensuring timely delivery of high-quality data aligned with R&D objectivesDesign and optimize gene editing cassettes, and gene expression vectorsDesign and optimize AAV-based and non-viral delivery constructs for therapeutic applicationsDevelop innovative approaches for gene therapy, validating and implementing new gene therapy and gene editing techniques to advance the field and internal R&D programsOversee experimental design and data interpretation for molecular biology assays including quantitative PCR, RT-PCR, ddPCR, next-generation sequencing, and protein analysis (Western blot, SDS-PAGE, immunofluorescence microscopy)Manage project timelines, resources, and internal and external collaborations; develop project strategies and troubleshoot experimental bottlenecksAuthor and review study reports, study protocols, SOPs, regulatory filings, and patent applicationsPresent scientific findings at internal meetings and external scientific conferences, representing AskBio in collaborationsMentor and train scientists at earlier career stages, promoting scientific growth and development within the teamStay current with the latest advancements in gene editing, gene therapy, and AAV biology, driving innovation within the groupMinimum RequirementsPhD with 5+ years’ experience (may include post-doctoral work) in Molecular Biology, Biochemistry, Genetics, Biomedical Sciences, or a related field; OR Master’s degree with 10+ years’ industry or related experience in a relevant disciplineDemonstrated experience in drug development and translating research from discovery through preclinical stagesExpertise in expression vector design, molecular cloning techniques, and gene therapy cassette design and optimizationHands-on experience with quantitative PCR, RT-PCR, and droplet digital PCR (ddPCR)Experience with next-generation sequencing (NGS) library preparation and data analysisProficiency in miRNA, shRNA, and siRNA design and applicationHands-on experience with mammalian cell culture, including primary cells and transduction assaysProficiency in protein analysis techniques: SDS-PAGE, Western blot, and immunofluorescence microscopyDemonstrated ability to lead cross-functional teams and manage multiple concurrent projectsPreferred Education, Experience and SkillsExperience with emerging gene editing technologies (e.g., CRISPR epigenomic editing, PRINT, or prime editing)Track record of publications and/or conference presentations in gene editing or gene therapyExperience with in vivo gene therapy studies and translational researchFamiliarity with regulatory requirements for gene therapy IND-enabling programsExperience managing external collaborations with academic or industry partnersPeople leadership experience, including direct reports and performance managementAskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at View phone number on click.appcast.io or sending us an email at View email address on click.appcast.io .Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency. #J-18808-Ljbffr Asklepios Biopharmaceutical Inc