Senior Director, Nonclinical Toxicology

Senior Director Nonclinical Toxicology

Lead toxicology strategy across discovery preclinical and clinical development at Nurix. As Senior Director Nonclinical Toxicology youll guide exploratory and GLP safety studies assess the human risk of novel therapeutic targets and help shape the regulatory documents that support global clinical development.

Position Description

The Opportunity

• Design and management of exploratory and GLP toxicology and safety pharmacology studies. Handle multiple projects in a timely and effective manner at various stages of discovery preclinical and clinical development. Write interact and/or contribute to all applicable Regulatory Documents/Authorities and Asset Teams.
• Lead toxicology strategy and tactics in discovery preclinical development and clinical development with a focus on understanding/assessing the human risk of novel therapeutic targets and/or understanding mode of action for toxicity in nonclinical studies
• Participate in multi-disciplinary team efforts and implement program-specific toxicology strategies to support compound and program progression
• Monitor outsourced GLP and non-GLP studies ensuring compliance with the protocol amendments regulations safety guidelines and standard operating procedures
• Write and review toxicology protocols reports and documentation for regulatory filings and participate in regulatory interactions
• Apply a broad understanding of toxicology pharmacology ADME and knowledge of applicable regulatory guidelines to the design of appropriate toxicology studies and development plans
• Provide creative approaches to expedite nonclinical development strategies
• Provide a critical review of toxicology study protocols data and study reports
• Serve as the Toxicology representative on multi-functional project teams supporting discovery and development phase projects
• Contribute to the preparation of high-quality regulatory documents supporting global clinical development and marketing authorizations
• Effectively communicate toxicology study results to project teams and senior level management
• Travel required as needed

What Youll Bring

Required Qualifications

• D. in Toxicology Pharmacology or a related field with a minimum of 10 years or M.S. degree with a minimum of 15 years of pharmaceutical or biotechnology industry experience as part of a drug development project team
• Extensive experience in discovery and development of small molecules degraders and antibody drug conjugates is desirable
• Experience in designing monitoring and interpreting nonclinical toxicology/safety pharmacology studies
• Experience in writing and reviewing nonclinical sections of regulatory documents (CTA IND IB NDA BLA etc.) and direct interactions with worldwide regulatory agencies
• Extensive drug development experience with strong decision making and problem-solving skills
• Excellent written and verbal communication skills which includes ability to communicate complex toxicology and safety issues clearly to key stakeholders
• Experience in health-authority interactions and developing regulatory strategies that require a high degree of scientific and strategic judgments
• Competency in incorporating the use of NAMs in toxicological evaluations to strengthen translational decision making

Bonus Qualifications

• Board certification in toxicology is highly desired

Salary Range: $ 312900 - $344900

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidates relevant experience technical expertise and how their background aligns with the roles requirements.

Location: Onsite Brisbane CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery development and commercialization of targeted protein degradation medicines the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class and coupled with unparalleled ligase expertise Nurixs dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care writing medicines next chapter with a new script to outmatch disease.

Required Experience:

Exec