Sr Manager IT, Microsoft 365 and Copilot

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Location

San Diego, CA.

Must currently reside in the San Diego metropolitan area or be able to commute independently. No relocation assistance is available for this hybrid role.

Position Summary

This role leads the team responsible for delivering and evolving Illumina's global email and collaboration services in Microsoft 365 with a strong focus on security, resiliency, governance, and user experience. This role owns the operational health and roadmap execution across core M365 workloads (e.g., Teams, SharePoint, OneDrive, Exchange, Viva Engage) and is an AI evangelist that drives adoption and governance for Microsoft 365 Copilot and agents at scale.

Responsibilities

• Build and lead a high-performing engineering/operations globally distributed team across regions and time zones; coach technical depth, operational rigor, and customer focus.
• Serve as the single-point accountable owner for collaboration services, balancing security, user experience, cost, and operational risk.
• Accountable for day-to-day administration and lifecycle management for M365 workloads, ensuring effective execution through team and partners.
• Act as the platform leader for Microsoft 365 Copilot rollout, including business use-case prioritization, executive readiness, adoption measurement, and value realization, with appropriate governance and stakeholder alignment.
• Manage vendor/partner engagement as needed (e.g., Microsoft/partners) to support roadmap execution, escalations, and best practice adoption.
• Serve as the service owner for enterprise collaboration services, ensuring secure and resilient delivery with strong user experience outcomes, including proficient budget and license management.
• Govern and operationalize OOTB Copilot agents: establish access/availability policies and manage agent inventory and lifecycle.
• Lead service operations practices: monitoring/alerting, incident response and escalations, change/release readiness, and continuous improvement.
• Establish and report on service health metrics (availability, incident trends, platform adoption, performance).
• Own collaboration governance (information protection alignment, tenant policy controls, workspace governance) to reduce oversharing and secure enterprise content.
• Partner with Security/Compliance stakeholders to implement and sustain controls (e.g., policies for risky workspaces/users, permission hygiene, and retention expectations,).
• Effectively manages critical business capabilities related to email services including legal-hold and compliance.

Requirements

• 10 years of Microsoft 365 IT ownership experience with 5+ years of management experience.
• Experience leading enterprise-scale collaboration platforms supporting 10,000+ users in regulated or security-sensitive environments.
• Hands-on leadership deploying and scaling Microsoft 365 Copilot: enablement, adoption, support model readiness, and stakeholder communications.
• Overall knowledge of most areas within particular Corporate sub-function or a function within an operation.
• Hybrid on-site role at San Diego Headquarters
• Excellent verbal and written communication skills.
• Demonstrated success scaling enterprise services or platforms across global teams
• Proven ability to translate platform strategy into measurable efficiency, risk reduction, or adoption outcomes
• Strong financial, analytical, and problem-solving skills.
• Adaptability to rapidly changing environments and technology.
• Experience presenting findings and challenges to senior executives.
• Results-focused with a track record of delivering across multiple projects and teams.
• Ability to lead through uncertainty, resolve conflicts, and adapt to change.

Education

• Typically requires a minimum of 12 years of related experience with a Bachelor's degree; or 8 years and a Master's degree, or equivalent experience.
• Advanced degree in Science, Business, Engineering or Computer Science preferred.

All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

#LI-HYBRID

The estimated base salary range for the Sr Manager IT, Microsoft 365 and Copilot role based in the United States of America is: $155,600 - $233,400. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long-term growth in the role. Most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact View email address on click.appcast.io. To learn more, visit: The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.