Research Associate I/II - Clinical Pathology/IHC Biomarker Development

SystImmune is a leading and well‑funded clinical‑stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It develops innovative cancer treatments using established drug development platforms, focusing on bi‑specific, multi‑specific antibodies, and antibody‑drug conjugates (ADCs). With multiple assets in various stages of clinical trials for solid‑tumor and hematologic indications, SystImmune also maintains a robust preclinical pipeline of potential therapeutics in the discovery and IND‑enabling stages. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. We are seeking a highly organized and detail‑oriented Research Associate I/II to support the development, optimization, and validation of immunohistochemistry (IHC) assays. This bench‑focused position will contribute to early‑stage biomarker discovery in support of clinical trial programs and requires close collaboration with scientists, pathologists, and cross‑functional project teams. Key Responsibilities Histology Perform tissue sectioning of FFPE blocks. Route and support H&E staining workflows. IHC Assay Execution Perform routine IHC staining on FFPE tissue specimens using automated platforms (e.g., Ventana, Leica). Conduct antibody titrations, protocol optimization, slide preparation, and quality control checks. Assist in generating feasibility, optimization, and analytical validation data for emerging CDx assays. Experience with Akoya PhenoImager HT platforms is preferred. Sample & Workflow Support Manage tissue samples and associated documentation. Prepare tissue sections, including slide cutting, baking, antigen retrieval, and reagent preparation. Maintain sample integrity, traceability, and documentation in compliance with quality system requirements. Support tissue‑handling workflows (blocks, slides, labeling, storage) within GLP or CLIA/CAP environments. Data Collection & Documentation Accurately record experimental data in ELN and/or LIMS systems. Capture high‑quality slide images and perform basic image analysis. Assist with slide‑scoring preparation and data summaries. Summarize experimental findings for internal meetings and assay development reviews. Instrument & Laboratory Maintenance Operate, calibrate, and troubleshoot automated IHC staining platforms and related laboratory equipment. Perform routine instrument maintenance and maintain equipment logs per laboratory quality systems. Monitor and manage inventory of reagents, antibodies, controls, and consumables. Cross‑functional Support Collaborate with scientists, pathologists, QA, and clinical development teams on assay transfer, optimization, and validation activities. Support preparation of study materials, controlled documents, and protocol execution for validation studies. Qualifications Required BS or MS in Biology, Molecular Biology, Pathology, Biomedical Sciences, or a related field. 1–3 years of hands‑on experience in histology and/or IHC assay execution within a research or regulated diagnostic laboratory. Experience handling FFPE tissues and operating automated IHC staining platforms. Strong attention to detail with excellent documentation and record‑keeping practices. Ability to follow SOPs and work effectively in CLIA‑, GxP‑, or ISO‑regulated environments. Preferred Experience supporting IHC assay optimization and/or analytical validation studies. Exposure to Akoya platforms and multiplex immunofluorescence projects. Experience with digital pathology, slide scanning, or image analysis tools. Knowledge of antibody characterization and tissue‑based biomarker assay development. Compensation and Benefits The expected base salary range for this position is $60,000 – $80,000 annually, with actual compensation based on qualifications, experience, and skills. The offer may be toward the higher end for exceptional candidates. Benefits include 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match up to 3% and a five‑year vesting schedule, 15 PTO days per year, sick leave, and 11 paid holidays. SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply. #J-18808-Ljbffr SystImmune Inc.