Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Decision Scientist, Applied Optimization and Simulation 2026 - US

Aimpoint Digital

Lead Decision Scientist

Aimpoint Digital is an AI and data consulting firm that turns AI ambition into production reality, built on the data and analytics foundation required to scale. This position is within our decision sciences practice which focuses on delivering production solutions via mathematical optimization and machine learning for our Federal customers. This role requires an active security clearance and a willingness to work on SIPR 2-4 days per week depending on project needs.

As a part of Aimpoint Digital, you will focus on enabling our Federal clients to get the most out of their data. Our Decision Science practice focuses on business, data, and process understanding to identify the best approach to solve our client's complex problems. We focus on delivering tangible value with models in production, not chasing theoretical boundaries with prototypes. Typical solutions will utilize machine learning, artificial intelligence, statistical analysis, automation, optimization, and data visualizations. As a Lead Decision Scientist you will:

  1. Become a trusted advisor working with clients to design and build end-to-end analytical solutions from initial solution architecture design through feature engineering, modeling, deployment, and maintenance
  2. Work independently to solve complex decision science use-cases across various industries using mathematical optimization, simulation, machine learning, statistical/mathematical modeling, and analytics to solve use cases for our federal clients
  3. Use your experience with decision science to build and manage agentic workflows to complete modeling tasks
  4. Flexibly lead projects, from hands-on single developer engagements through complex projects coordinating between account management and a team of developers across Aimpoint
  5. Manage or mentor junior decision scientists through their career at Aimpoint
  6. Synthesize insights and construct narratives to influence decision making using optimization, simulation, statistics, ML modeling, and other techniques
  7. Write code in Python following software engineering best practices
  8. Take models from development to production in client environments following DecisionOps/MLOps best practices
  9. Collaborate with stakeholders and customers to ensure successful project delivery
  10. Assist with technical proposal and GTM material development
  11. Contribute to the Aimpoint perspective on agentic and AI accelerated decision science
  12. Lead and deliver internal practice development initiatives

We are looking for collaborative individuals who want to drive value, work in a fast-paced environment, and solve real business problems. You are a coder who uses AI to write efficient and optimized code. You are a problem-solver who can deliver simple, elegant solutions as well as cutting-edge solutions that, regardless of complexity, your clients can understand, implement, and maintain. You genuinely think about the end-to-end machine learning pipeline as you generate robust solutions. You are both a teacher and a student as we enable our clients, upskill our teammates, and learn from one another. You want to drive impact for your clients and do so through thoughtfulness, prioritization, and seeing a solution through from brainstorming to deployment. In particular you have these traits:

  • Active Secret or higher security clearance
  • Willingness and ability to work on-site in a facility with SIPR access for 2-4 days per week
  • MS/PhD in Operations Research, Industrial Engineering, Computer Science, Mathematics, Engineering, or other STEM-related field
  • MS + 5-6 years practical experience
  • PHD + 4-5 years practical experience
  • Strong theoretical knowledge of optimization techniques, including linear programming and integer programming and/or dynamic programming and graph theory
  • Proficiency in a programming language such as Python, and/or proficiency in an optimization platform, AIMMS/AMPL/GAMS/Pyomo
  • Practical experience with open-source solvers and commercial solvers, such as Gurobi, CPLEX or XPRESS
  • Required competency in Python for data manipulation and modeling via classical ML methodologies
  • Demonstrated evidence of experience with end-to-end model development including but not limited to:
    • Requirements gathering
  • Solution design / architecture
  • EDA / data validation
  • Model development and testing
  • Model deployment
  • Model maintenance
  • Business user handoff / training
  • Experience communicating complex topics and results to high-level stakeholders. Strong written and verbal communication skills are required.
  • Self-starter with excellent communication skills, able to work independently, and lead projects, initiatives, and/or people

We are actively seeking candidates for full-time, remote work within the US.

Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Principal Decision Scientist, Applied Optimization and Simulation 2026 - US in United States vacancy
  • Principal Decision Scientist, Applied Optimization and Simulation 2026 - US Aimpoint Digital is a premier analytics consulting firm with a mission to drive business value for clients through expertise in data strategy, data analytics, decision science, data engineering... 
    Principal
    Full time
    Remote work

    Aimpoint Digital

    Atlanta, GA
    4 days ago
  • $126k - $234k

     ...Hybrid Internal Title: Principal Scientist II or Senior...  ...teams to develop and apply model-informed approaches...  ...to inform key decisions from early dose optimization through life-cycle...  ...to a Modeling and Simulation (M&S) team lead within...  ...equity awards.US-based eligible employees... 
    Principal
    Full time

    Novartis

    Cambridge, MA
    4 days ago
  • $131.4k - $236k

     ...work orders.In August 2026 MaintainX became...  ...looking for a Senior Applied Scientist to own the intelligence...  ...when to reorder, how to optimize stock levels across...  ...will be building the decision models, optimization...  ...stochastic programming, simulation) and practical... 
    Suggested

    MaintainX

    San Francisco, CA
    4 days ago
  • $156.9k - $247k

     ...for a new Associate Principal Scientist to join our...  ...Health Economic and Decision Sciences group. The...  ...predictive modeling and simulation in partnership...  ...challenges in the US and key international...  ...Current Employees apply HERECurrent...  ...Posting End Date:09/21/2026*A job posting is... 
    Principal
    Full time
    For contractors
    Work experience placement
    Work at office
    Local area
    Flexible hours

    Merck Sharp & Dohme (MSD)

    Boston, MA
    2 days ago
  • $142.8k - $274.8k

     ...Our mission requires us to push the frontier...  ...threat landscape. As a Principal Applied Scientist on the Microsoft Ads...  ...Starting January 26, 2026, Microsoft AI (MAI)...  ..., and continuous optimization under real-world operating...  ...and low-latency decision pipelines that operate... 
    Principal
    Ongoing contract
    Work at office
    Local area

    Microsoft Corporation

    Redmond, WA
    3 days ago
  • $158.3k - $355.4k

     ...designing, training, and optimizing ML/AI models and...  ...disability at any point, let us know by emailing...  ...Identifies opportunities to apply delivered solutions across...  ...assessment, and hiring decisions, ensuring alignment...  ...talent strategy.Full timePosting Date: 2026-08-25
    Principal
    Temporary work
    Flexible hours
    Shift work

    Oracle Corporation

    Santa Clara, CA
    2 days ago
  • $160k - $220k

     ...RoleWe’re looking for an Applied Scientist to turn Sprinter’s hardest...  ...logistics problems into optimization models and decision systems that get the right...  .... You'll usually find us playing a board game before...  ...optimization, forecasting, or simulation tasks.Build strong... 
    Temporary work
    Work at office
    Monday to Friday
    Monday to Thursday

    Sprinter Health

    San Francisco, CA
    4 days ago
  •  ...premier analytics consulting firm is seeking a Principal Decision Scientist to drive business value through optimization and data science. The role involves defining business...  ...in Python. This position is remote within the US, with an office option for Atlanta-based... 
    Remote job
    Work at office

    Aimpoint Digital

    Atlanta, GA
    4 days ago
  • $170.6k - $250k

     ...experienced AI scientist and technical leader...  ...vehicle simulation. In this role,...  ...systems.As a Senior Principal AI Scientist,...  ...understanding how decisions in data...  ...Benefits available to US-based HERE...  ...or a business optimize its assets to guiding...  ...ID: 2026-81677Category:... 
    Principal
    Remote work

    Here

    Chicago, IL
    4 days ago
  •  ...healthcare innovation empowers us to build a world where...  ...for the best talent for Principal Scientist, Biologics Optimization in Spring House,...  ...pathways to guide engineering decisions. This role offers the opportunity...  ...-driven decision making. Apply computational, AI/ML, and... 
    Principal
    Full time
    Local area

    Johnson & Johnson

    Spring House, PA
    3 days ago
  • $158.3k - $355.4k

     ...seeking an exceptional Senior Principal Applied Scientist to develop AI-enabled...  ...disability at any point, let us know by emailing accommodation...  ...influence product and platform decisions across science, engineering,...  ...major cloud platform.Full timePosting Date: 2026-08-19
    Principal
    Temporary work
    Immediate start
    Flexible hours

    Oracle Corporation

    Nashville, TN
    5 days ago
  •  ...spatial intelligence, helping decision makers and operators...  ...protection for PR task forces.The Principal Applied Scientist serves as the scientific...  ...of advanced analytical and simulation models supporting characterization...  ....Minimum Qualifications:US Citizen and must have an... 
    Principal
    Full time

    Maxar Technologies

    Herndon, VA
    1 day ago
  • $142.8k - $274.8k

     ...ID: 200033241Posted: 2026-07-28Location: United...  ...Profession: Research, Applied, & Data SciencesDiscipline...  ...focuses on optimizing ad performance for all...  ...In our team, applied scientists work together and utilize...  ...statistical machine learning, decision theory, operations... 
    Principal
    Ongoing contract
    Work at office
    Local area

    Microsoft

    Redmond, WA
    2 days ago
  •  ...purpose.Could that be you?As a Principal Applied Scientist, you will lead the...  ..., reinforcement learning, simulation environments, tool use, and...  ...orchestration frameworks, and decision-making systems.• Lead the...  ...preparation, inference optimization, or model evaluation.• Experience... 
    Principal
    Work at office
    Immediate start
    Remote work

    UiPath

    Bellevue, WA
    2 days ago
  • $142.5k - $256.5k

     ...experienced, and highly motivated Principal Scientist to build, optimize, and execute T cell...  ...successful candidate will apply deep expertise in display-...  ...iterative optimization decisions.Interpret complex screening...  ...and direct mentorship. Join us in shaping a world where... 
    Principal
    Permanent employment
    Full time
    Work at office
    Work from home

    Moderna Therapeutics

    Cambridge, MA
    2 days ago
  • $147.7k - $199.82k

     ...the Amgen team. Join us and transform the lives...  ...your career.Principal Scientist - Clinical Pharmacology...  ...actionable drug-development decisions.Key...  ...review of modeling & simulation plans, evaluation of...  ...posting to see if this applies.Apply now and make a... 
    Principal
    Full time
    Flexible hours

    Amgen

    Thousand Oaks, CA
    5 days ago
  • $228.7k - $309.4k

    As a Principal Applied Scientist for Full-Funnel Campaign optimization, you will invent the models that jointly allocate budget across sponsored ad products to maximize advertiser outcomes and long-term customer value.This is a rare charter to build foundational optimization... 
    Principal
    Local area
    Flexible hours
    Day shift

    Amazon

    Palo Alto, CA
    4 days ago
  • $142.8k - $274.8k

     ...ID: 200044808Posted: 2026-07-27Location:...  ...Profession: Research, Applied, & Data SciencesDiscipline...  ...tools. As a Principal Applied Scientist, you will define scientific...  ..., and more informed decisions.Microsoft’s mission...  ...recognition, and optimization. You should be comfortable... 
    Principal
    Ongoing contract
    Work at office
    Local area
    Immediate start

    Microsoft

    Redmond, WA
    4 days ago
  • $126.2k - $264.1k

     ...AI solutions. Leads end-to-end applied research across next-...  ...designs, trains, evaluates, and optimizes models for real-world deployment...  ...disability at any point, let us know by emailing accommodation...  ...providing hiring recommendations.Full timePosting Date: 2026-07-23
    Principal
    Temporary work
    Flexible hours
    Shift work

    Oracle Corporation

    Nashville, TN
    2 days ago
  • $144.9k - $269.1k

     ...’s what drives us to innovate. To...  ...computational chemist to apply cutting-edge...  ...pipeline, optimizing lead candidates...  ...wet-lab scientists.Cross-Functional...  ...informed and driven decisions. Collaborate...  ...docking, molecular simulation and dynamics,...  ...7Date posted : 2026-07-07Profession... 
    Principal
    Full time
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    3 days ago
  • $167.1k - $226.1k

     ...looking for an experienced applied optimization expert. This leader will join...  ...design, implement, and scale decision-making algorithms to...  ...review approaches by other scientists and engineers in terms of business...  ...culture of inclusion that empower us to be proud of our... 
    Flexible hours

    AmazonWebServices

    Seattle, WA
    3 days ago
  • $142.8k - $193.2k

    Amazon's Modeling and Optimization (MOP) team seeks motivated individual...  ...through data-driven simulation and optimization- Reduce variable...  ...Drive planning and execution decisions on operation timing and...  ...software development- Experience applying mathematical programming,... 
    Flexible hours

    Amazon

    Bellevue, WA
    1 day ago
  • $142.8k - $193.2k

     ...teams of hundreds of scientists, engineers, aerospace...  ...can drive innovation, apply state-of-the-art...  ...background in developing simulations for traffic management...  ...technical decisions. If you enjoy the process...  ..., parsing, numerical optimization, data mining, parallel... 
    Worldwide
    Flexible hours

    Amazon

    Seattle, WA
    4 days ago
  • $142.8k - $193.2k

     ...Surface Research Science seeks an Applied Scientist to invent and build optimization models and algorithm to improve...  .... Operating it requires constant decisions about how to route, schedule, and...  ...test your new model features- Run a simulation or experiment to evaluate your... 
    Local area
    Flexible hours

    Amazon

    Bellevue, WA
    4 days ago
  • $146k - $236k

     ...AI systems that accelerate translational decision making. This forward-deployed role bridges...  ...serve as an expert test user for the Applied AI and Engineering teams, feeding field discoveries...  ...bigger leaps. Our core values guide us through uncertainty and toward lasting... 
    Principal

    Seres Therapeutics

    Cambridge, MA
    2 days ago
  •  ...scientifically rigorous AI co-scientists that enhance compound design...  ...hypothesis generation, and decision-making. Although the primary...  ...Transformation Through Applied AI and Agentic SystemsDrive...  ...molecular design, and lead optimization, leveraging established computational... 
    Principal
    Full time
    Summer work
    Remote work
    Flexible hours
    2 days per week
    3 days per week

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  • $214.1k - $337k

     ...DescriptionSenior Principal Scientist - Boston,...  ...strengthen experimental decision-making, and advance...  ...-to-lead, lead optimization, and pharmacology...  ...Demonstrated experience applying quantitative...  ...and other US State ActsThe salary...  ...Posting End Date:09/25/2026*A job posting is... 
    Principal
    Full time
    For contractors
    Local area

    Merck Sharp & Dohme (MSD)

    Boston, MA
    3 days ago
  • $179k

     ...advertising lifecycle from ad creation and optimization to performance analysis and customer...  ...boundaries of what's possible with AI, join us in shaping the future of advertising. Key job responsibilitiesThe Principal Applied Scientist in Advertiser Guidance team will lead 50... 
    Principal
    Local area

    Amazon

    Palo Alto, CA
    2 days ago
  • $198.9k - $269k

    The Principal Applied Scientist will own the science mission for building next-generation proactive and...  ...multi-step task planning, autonomous decision-making, proactive intelligence, and...  ...engineering efforts to meet timelines with optimal solutions.Preferred qualification... 
    Principal
    Worldwide
    Flexible hours

    Amazon

    Bellevue, WA
    2 days ago
  • $143.53k - $194.18k

     ...part of the Amgen team. Join us and transform the lives of...  ...while transforming your career.Principal Scientist - Modeling & SimulationWhat...  ...Pharmacology, Modeling and Simulation department.Key ResponsibilitiesBuilding...  ...and Bayesian methods as applied to exposure-response... 
    Principal
    Full time
    Flexible hours

    Amgen

    Thousand Oaks, CA
    4 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Decision Scientist, Applied Optimization and Simulation 2026 - US. Be the first to apply!